Rheumatoid arthritis patients display B-cell dysregulation already in the naïve repertoire consistent with defects in B-cell tolerance

Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis

(2019) Katy A. Lloyd et al.   Frontiers in Immunology

Affinity Maturation of the Anti–Citrullinated Protein Antibody Paratope Drives Epitope Spreading and Polyreactivity in Rheumatoid Arthritis

(2019) Sarah Kongpachith et al.   Arthritis & Rheumatology

Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts

(2019) Akilan Krishnamurthy et al.   JOURNAL OF IMMUNOLOGY

Non-response to rituximab therapy in rheumatoid arthritis is associated with incomplete disruption of the B cell receptor repertoire

(2019) Sabrina Pollastro et al.   ANNALS OF THE RHEUMATIC DISEASES

Cartilage-binding antibodies induce pain through immune complex–mediated activation of neurons

(2019) Alex Bersellini Farinotti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts

(2019) Meng Sun et al.   ANNALS OF THE RHEUMATIC DISEASES

Variable domain N-linked glycosylation and negative surface charge are key features of monoclonal ACPA: Implications for B-cell selection

(2018) Katy A. Lloyd et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

On the origin of rheumatoid factors: Insights from analyses of variable region sequences

(2018) Willem J.J. Falkenburg et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

T cell-dependent affinity maturation and innate immune pathways differentially drive autoreactive B cell responses in rheumatoid arthritis

(2018) Daniel R. Lu et al.   Arthritis & Rheumatology

Pathogenic citrulline-multispecific B cell receptor clades in rheumatoid arthritis

(2018) Philip J Titcombe et al.   Arthritis & Rheumatology

Affinity Maturation Drives Epitope Spreading and Generation of Pro-inflammatory Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis

(2018) Serra E. Elliott et al.   Arthritis & Rheumatology

Determination of Autoantibody Isotypes Increases the Sensitivity of Serodiagnostics in Rheumatoid Arthritis

(2018) Daniela Sieghart et al.   Frontiers in Immunology

Sialic Acid Ligand Binding of CD22 and Siglec-G Determines Distinct B Cell Functions but Is Dispensable for B Cell Tolerance Induction

(2018) Lamia Özgör et al.   JOURNAL OF IMMUNOLOGY

The parallel worlds of ACPA-positive and RF-positive B cells

(2018) Vivianne Malmström et al.   Nature Reviews Rheumatology

Human plasma cell derived monoclonal antibodies to post-translationally modified proteins recognize amino acid motifs rather than specific proteins

(2018) Johanna Steen et al.   Arthritis & Rheumatology

CD22: A Regulator of Innate and Adaptive B Cell Responses and Autoimmunity

(2018) Edward A. Clark et al.   Frontiers in Immunology

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

Generation and characterization of anti-citrullinated protein antibody-producing B-cell clones from rheumatoid arthritis patients

(2018) Kristine Germar et al.   Arthritis & Rheumatology

Autoreactivity to malondialdehyde-modifications in rheumatoid arthritis is linked to disease activity and synovial pathogenesis

(2017) Caroline Grönwall et al.   JOURNAL OF AUTOIMMUNITY

B-cell phenotype and IgD-CD27- memory B cells are affected by TNF-inhibitors and tocilizumab treatment in rheumatoid arthritis

(2017) Rita A. Moura et al.   PLoS One

IgM antibodies against malondialdehyde and phosphorylcholine are together strong protection markers for atherosclerosis in systemic lupus erythematosus: Regulation and underlying mechanisms

(2016) Mizanur Rahman et al.   CLINICAL IMMUNOLOGY

Structural Analysis of Variable Domain Glycosylation of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Reveals the Presence of Highly Sialylated Glycans

(2016) Lise Hafkenscheid et al.   MOLECULAR & CELLULAR PROTEOMICS

Autoantibodies to two novel peptides in seronegative and early rheumatoid arthritis

(2016) Liesbeth M. De Winter et al.   RHEUMATOLOGY

Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching

(2016) Felix Horns et al.   eLife

Elevated IgA Plasmablast Levels in Subjects at Risk of Developing Rheumatoid Arthritis

(2016) Jennifer D. Kinslow et al.   Arthritis & Rheumatology

Antibodies toPorphyromonas gingivalisIndicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology

(2016) Nastya Kharlamova et al.   Arthritis & Rheumatology

Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism

(2015) Gustaf Wigerblad et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

(2015) Akilan Krishnamurthy et al.   ANNALS OF THE RHEUMATIC DISEASES

FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data

(2015) Sofie Van Gassen et al.   CYTOMETRY PART A

Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

(2015) Kira Rubtsova et al.   JOURNAL OF IMMUNOLOGY

Associations With Smoking and Shared Epitope Differ Between IgA- and IgG-Class Antibodies to Cyclic Citrullinated Peptides in Early Rheumatoid Arthritis

(2015) Anna Svärd et al.   Arthritis & Rheumatology

Malondialdehyde-Acetaldehyde Adducts and Anti-Malondialdehyde-Acetaldehyde Antibodies in Rheumatoid Arthritis

(2015) Geoffrey M. Thiele et al.   Arthritis & Rheumatology

pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires

(2014) Jason A. Vander Heiden et al.   BIOINFORMATICS

IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L

(2014) Alexander Viktorin et al.   HUMAN MOLECULAR GENETICS

Natural IgM: Beneficial Autoantibodies for the Control of Inflammatory and Autoimmune Disease

(2014) Caroline Grönwall et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Sequencing the functional antibody repertoire—diagnostic and therapeutic discovery

(2014) William H. Robinson   Nature Reviews Rheumatology

Rheumatoid arthritis synovial tissue harbours dominant B-cell and plasma-cell clones associated with autoreactivity

(2013) M E Doorenspleet et al.   ANNALS OF THE RHEUMATIC DISEASES

High frequencies of activated B cells and follicular helper T cells are correlated with disease activity in patients with new onset rheumatoid arthritis

(2013) Juan Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Protective autoantibodies in the rheumatic diseases: lessons for therapy

(2013) Gregg J. Silverman et al.   Nature Reviews Rheumatology

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

(2013) Jose U Scher et al.   eLife

Structural Changes and Antibody Enrichment in the Lungs Are Early Features of Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis

(2013) Gudrun Reynisdottir et al.   Arthritis & Rheumatology

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

(2012) Ulrike Harre et al.   JOURNAL OF CLINICAL INVESTIGATION

MAPK phosphatase-1 is required for regulatory natural autoantibody-mediated inhibition of TLR responses

(2012) C. Gronwall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides

(2012) Monika Hansson et al.   ARTHRITIS RESEARCH & THERAPY

Advances in Human B Cell Phenotypic Profiling

(2012) Denise A. Kaminski et al.   Frontiers in Immunology

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

(2011) A. V. Rubtsov et al.   BLOOD

Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage

(2011) J. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

(2010) D. van der Woude et al.   ANNALS OF THE RHEUMATIC DISEASES

Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke

(2010) H. Kallberg et al.   ANNALS OF THE RHEUMATIC DISEASES

2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2010) D. Aletaha et al.   ANNALS OF THE RHEUMATIC DISEASES

Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor

(2010) Jeremy Sokolove et al.   ARTHRITIS AND RHEUMATISM

Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones

(2010) I. Isnardi et al.   BLOOD

Somatic hypermutation and antigen-driven selection of B cells are altered in autoimmune diseases

(2010) Neta S. Zuckerman et al.   JOURNAL OF AUTOIMMUNITY

Regulation of Dendritic Cells and Macrophages by an Anti-Apoptotic Cell Natural Antibody that Suppresses TLR Responses and Inhibits Inflammatory Arthritis

(2009) Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells

(2008) D Makrygiannakis et al.   ANNALS OF THE RHEUMATIC DISEASES

Antibodies to citrullinated α-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase

(2008) Karin Lundberg et al.   ARTHRITIS AND RHEUMATISM