A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms

Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections

(2020) Duy‐Khiet Ho et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

(2020) Fadi Soukarieh et al.   Frontiers in Chemistry

Preclinical Development of Orally Inhaled Drugs (OIDs)—Are Animal Models Predictive or Shall We Move Towards In Vitro Non-Animal Models?

(2020) Dania Movia et al.   Animals

Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection

(2020) Xabier Murgia et al.   Scientific Reports

Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809

(2019) Jake E. Doiron et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cystic Fibrosis and Pseudomonas aeruginosa: the Host-Microbe Interface

(2019) Sankalp Malhotra et al.   CLINICAL MICROBIOLOGY REVIEWS

Flexible Fragment Growing Boosts Potency of Quorum‐Sensing Inhibitors against Pseudomonas aeruginosa Virulence

(2019) Michael Zender et al.   ChemMedChem

Challenges and strategies in drug delivery systems for treatment of pulmonary infections

(2019) Duy-Khiet Ho et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Antibiotic efficacy varies based on the infection model and treatment regimen for Pseudomonas aeruginosa

(2019) Cristina Cigana et al.   EUROPEAN RESPIRATORY JOURNAL

The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics

(2018) Michelle F. Richter et al.   Annals of the New York Academy of Sciences

Pseudomonas aeruginosatranscriptome during human infection

(2018) Daniel M. Cornforth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers

(2018) Christian Schütz et al.   Beilstein Journal of Organic Chemistry

Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: A longitudinal study

(2017) Helen L. Barr et al.   Journal of Cystic Fibrosis

Predictive compound accumulation rules yield a broad-spectrum antibiotic

(2017) Michelle F. Richter et al.   NATURE

Structure–functionality relationship and pharmacological profiles of Pseudomonas aeruginosa alkylquinolone quorum sensing modulators

(2017) Ahmed A. M. Kamal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bezlotoxumab: A Novel Agent for the Prevention of Recurrent Clostridium difficile Infection

(2017) Wesley D. Kufel et al.   PHARMACOTHERAPY

Application of Dual Inhibition Concept within Looped Autoregulatory Systems toward Antivirulence Agents against Pseudomonas aeruginosa Infections

(2016) Andreas Thomann et al.   ACS Chemical Biology

Biofilm Antimicrobial Susceptibility Increases With Antimicrobial Exposure Time

(2016) Paulo Castaneda et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

The Approach to Pseudomonas aeruginosa in Cystic Fibrosis

(2016) Jaideep S. Talwalkar et al.   CLINICS IN CHEST MEDICINE

Insights into host-pathogen interactions from state-of-the-art animal models of respiratoryPseudomonas aeruginosainfections

(2016) Anne Lorenz et al.   FEBS LETTERS

Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections

(2016) Stefanie Wagner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic challenges posed by critical drug-drug interactions in cystic fibrosis

(2016) Cameron L. Jordan et al.   PEDIATRIC PULMONOLOGY

Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa

(2016) Giordano Rampioni et al.   PLoS Pathogens

An analysis of the attrition of drug candidates from four major pharmaceutical companies

(2015) Michael J. Waring et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity

(2014) Melissa Starkey et al.   PLoS Pathogens

Extracellular DNA Shields against Aminoglycosides in Pseudomonas aeruginosa Biofilms

(2013) Wen-Chi Chiang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Braces for the Peptide Backbone: Insights into Structure-Activity Relationships of Protease Inhibitor Mimics with Locked Amide Conformations

(2012) Marco Tischler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pseudomonas aeruginosa: all roads lead to resistance

(2011) Elena B.M. Breidenstein et al.   TRENDS IN MICROBIOLOGY

Murine models of acute and chronic lung infection with cystic fibrosis pathogens

(2010) Alessandra Bragonzi   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

Pseudomonas aeruginosa – a phenomenon of bacterial resistance

(2009) Tanya Strateva et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Synthesis and Antibiofilm Activity of a Second-Generation Reverse-Amide Oroidin Library: A Structure-Activity Relationship Study

(2008) T. Eric Ballard et al.   CHEMISTRY-A EUROPEAN JOURNAL