期刊
JOURNAL OF IMMUNOLOGY RESEARCH
卷 2021, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2021/5531220
关键词
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类别
资金
- Health and Medical Research Fund [COVID190117]
- Shenzhen Peacock Team Project [KQTD2015033117210153]
- Shenzhen Science and Technology Innovation Committee Basic Science Research Grant [JCYJ20170413154523577]
- China Postdoctoral Science Foundation [2019 M663167]
- City University of Hong Kong [9610472]
- General Research Fund (GRF) of University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) [9042951]
- NSFC/RGC Joint Research Scheme [N_CityU118/20]
- L & T Charitable Foundation
This article investigates the intradermal delivery of NP antigen using dissolvable microneedle skin patches to induce significant B cell and T cell responses.
The nucleocapsid protein (NP) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains immunogenic epitopes that can induce cytotoxic T lymphocyte (CTL) against viral infection. This makes the nucleocapsid protein a suitable candidate for developing a vaccine against SARS-CoV-2 infection. This article reports the intradermal delivery of NP antigen using dissolvable microneedle skin patches that could induce both significant B cell and T cell responses.
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