Temporal dynamics of a CSF1R signaling gene regulatory network involved in epilepsy

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain

(2019) Lihong Zhan et al.   PLOS BIOLOGY

Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

(2019) Annamaria Vezzani et al.   Nature Reviews Neurology

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

(2019) Renzo Mancuso et al.   BRAIN

The Family of LPS Signal Transducers Increases: the Arrival of Chanzymes

(2018) Francesca Granucci   IMMUNITY

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

(2018) Justyna Sosna et al.   Molecular Neurodegeneration

A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target

(2018) Prashant K. Srivastava et al.   Nature Communications

Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo

(2018) Nynke Oosterhof et al.   Cell Reports

Mathematical Analysis of Cytokine-Induced Differentiation of Granulocyte-Monocyte Progenitor Cells

(2018) Bronson R. Weston et al.   Frontiers in Immunology

Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells

(2018) Scott Rata et al.   CURRENT BIOLOGY

Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation

(2017) Evan A. Conaway et al.   JOURNAL OF IMMUNOLOGY

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

(2017) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

Drug development for refractory epilepsy: The past 25 years and beyond

(2017) Ambica Golyala et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy

(2017) Michael A. Cannarile et al.   Journal for ImmunoTherapy of Cancer

Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88

(2017) Jiro Sakai et al.   Scientific Reports

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

(2016) Adrian Olmos-Alonso et al.   BRAIN

Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass

(2016) Emma C. Walker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The complexities and versatility of the RAS-to-ERK signalling system in normal and cancer cells

(2016) Dirk Fey et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

C/EBPα in normal and malignant myelopoiesis

(2015) Alan D. Friedman   INTERNATIONAL JOURNAL OF HEMATOLOGY

Frequency modulation of ERK activation dynamics rewires cell fate

(2015) H. Ryu et al.   Molecular Systems Biology

Cooperative Transcriptional Activation of Antimicrobial Genes by STAT and NF-κB Pathways by Concerted Recruitment of the Mediator Complex

(2015) Sebastian Wienerroither et al.   Cell Reports

Type 1 TNF Receptor Forms a Complex with and Uses Jak2 and c-Src to Selectively Engage Signaling Pathways That Regulate Transcription Factor Activity

(2014) R. Pincheira et al.   JOURNAL OF IMMUNOLOGY

CSF-1 Receptor Signaling in Myeloid Cells

(2014) E. R. Stanley et al.   Cold Spring Harbor Perspectives in Biology

Latent Enhancers Activated by Stimulation in Differentiated Cells

(2013) Renato Ostuni et al.   CELL

Crosstalk between the Type 1 Interferon and Nuclear Factor Kappa B Pathways Confers Resistance to a Lethal Virus Infection

(2013) Daniel Rubio et al.   Cell Host & Microbe

Lipopolysaccharide inhibits the expression of resistin in adipocytes

(2013) Xinxin Xiang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Effect of natural genetic variation on enhancer selection and function

(2013) S. Heinz et al.   NATURE

The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy

(2013) H.L. Grabenstatter et al.   NEUROBIOLOGY OF DISEASE

Cell-intrinsic role for IFN- -STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response

(2011) H. S. Li et al.   BLOOD

A Requirement of STAT3 DNA Binding Precludes Th-1 Immunostimulatory Gene Expression by NF- B in Tumors

(2011) H. Lee et al.   CANCER RESEARCH

TNFR1-induced activation of the classical NF-κB pathway

(2011) Harald Wajant et al.   FEBS Journal

IRF7: activation, regulation, modification and function

(2011) S Ning et al.   GENES AND IMMUNITY

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

(2010) Lydia Durant et al.   IMMUNITY

Oncostatin M Enhances the Antiviral Effects of Type I Interferon and Activates Immunostimulatory Functions in Liver Epithelial Cells

(2009) E. Larrea et al.   JOURNAL OF VIROLOGY

PU.1 is regulated by NF-κB through a novel binding site in a 17 kb upstream enhancer element

(2009) N Bonadies et al.   ONCOGENE

Intractable epilepsy: management and therapeutic alternatives

(2008) Stephan U Schuele et al.   LANCET NEUROLOGY