SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells

Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

(2019) Xiuquan Ma et al.   Nature Communications

Metabolomics and Isotope Tracing

(2018) Cholsoon Jang et al.   CELL

SGK1/FOXO3 Signaling in Hypothalamic POMC Neurons Mediates Glucocorticoid-Increased Adiposity

(2018) Yalan Deng et al.   DIABETES

Mechanisms of redox metabolism and cancer cell survival during extracellular matrix detachment

(2018) Mark A. Hawk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells

(2018) Mark A. Hawk et al.   NATURE CELL BIOLOGY

A Large-Scale RNAi Screen Identifies SGK1 as a Key Survival Kinase for GBM Stem Cells

(2017) Shreya Kulkarni et al.   MOLECULAR CANCER RESEARCH

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

(2016) Pau Castel et al.   CANCER CELL

Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells

(2016) J A Mason et al.   CELL DEATH AND DIFFERENTIATION

SGK1, the New Player in the Game of Resistance: Chemo-Radio Molecular Target and Strategy for Inhibition

(2016) Cristina Talarico et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions

(2016) Inmaculada Martínez-Reyes et al.   MOLECULAR CELL

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet

(2015) Xiaojing Liu et al.   MOLECULAR & CELLULAR PROTEOMICS

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

(2015) J. Yun et al.   SCIENCE

Targeting the glucocorticoid receptor in breast and prostate cancers

(2015) Jacob Kach et al.   Science Translational Medicine

Development and Quantitative Evaluation of a High-Resolution Metabolomics Technology

(2014) Xiaojing Liu et al.   ANALYTICAL CHEMISTRY

CAF-Secreted IGFBPs Regulate Breast Cancer Cell Anoikis

(2014) Kelsey J. Weigel et al.   MOLECULAR CANCER RESEARCH

The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex

(2014) Emily B Heikamp et al.   NATURE IMMUNOLOGY

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Antioxidant Enzymes Mediate Survival of Breast Cancer Cells Deprived of Extracellular Matrix

(2013) C. A. Davison et al.   CANCER RESEARCH

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Activation of serum/glucocorticoid-induced kinase 1 (SGK1) underlies increased glycogen levels, mTOR activation, and autophagy defects in Lafora disease

(2013) Pankaj Kumar Singh et al.   MOLECULAR BIOLOGY OF THE CELL

Serum and glucocorticoid-regulated kinase 1 (SGK1) activation in breast cancer: requirement for mTORC1 activity associates with ER-alpha expression

(2012) Ben A. Hall et al.   BREAST CANCER RESEARCH AND TREATMENT

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

EMD638683, a Novel SGK Inhibitor with Antihypertensive Potency

(2011) Teresa F. Ackermann et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation

(2011) A. R. Grassian et al.   GENES & DEVELOPMENT

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment

(2011) A. Avivar-Valderas et al.   MOLECULAR AND CELLULAR BIOLOGY

Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells

(2011) U-M Fagerli et al.   ONCOGENE

Second AKT: The rise of SGK in cancer signalling

(2010) Maressa A. Bruhn et al.   GROWTH FACTORS

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

(2007) Christopher Fung et al.   MOLECULAR BIOLOGY OF THE CELL