Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes

Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer’s disease

(2021) Weiwei Yu et al.   CLINICAL SCIENCE

Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease

(2020) Sang Su Kwak et al.   Nature Communications

Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings

(2020) Selene Lomoio et al.   Science Translational Medicine

Increased ER–mitochondria tethering promotes axon regeneration

(2019) Soyeon Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Synaptic Plasticity in Experimental Models of Alzheimer’s Disease

(2019) Dalila Mango et al.   Frontiers in Pharmacology

Perturbed mitochondria-ER contacts in live neurons modelling Alzheimer's disease amyloid pathology

(2019) Pamela V. Martino Adami et al.   JOURNAL OF CELL SCIENCE

Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases

(2019) Daniel A. Ryskamp et al.   Frontiers in Neuroscience

DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1

(2019) Yi Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

(2019) Dylan Kwart et al.   NEURON

Mitochondria-associated ER membranes (MAMs) and lysosomal storage diseases

(2018) Ida Annunziata et al.   Cell Death & Disease

Amyloid-β Peptides are Generated in Mitochondria-Associated Endoplasmic Reticulum Membranes

(2018) Bernadette Schreiner et al.   JOURNAL OF ALZHEIMERS DISEASE

Interaction of Mitochondria with the Endoplasmic Reticulum and Plasma Membrane in Calcium Homeostasis, Lipid Trafficking and Mitochondrial Structure

(2017) Jędrzej Szymański et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel fluorescent reporter detects plastic remodeling of mitochondria–ER contact sites

(2017) Zhaoying Yang et al.   JOURNAL OF CELL SCIENCE

From dysfunctional endoplasmic reticulum-mitochondria coupling to neurodegeneration

(2017) Zoi Erpapazoglou et al.   NEUROCHEMISTRY INTERNATIONAL

Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production

(2016) Nuno Santos Leal et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice

(2016) Aleix Sala-Vila et al.   Scientific Reports

Palmitoylated APP Forms Dimers, Cleaved by BACE1

(2016) Raja Bhattacharyya et al.   PLoS One

Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer’s disease

(2016) Peter Koppensteiner et al.   Scientific Reports

Early etiology of Alzheimer’s disease: tipping the balance toward autophagy or endosomal dysfunction?

(2015) Aleksandar Peric et al.   ACTA NEUROPATHOLOGICA

Alzheimer's in 3D culture: Challenges and perspectives

(2015) Carla D'Avanzo et al.   BIOESSAYS

Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration

(2015) Nathalie Bernard-Marissal et al.   BRAIN

Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing

(2015) Emily D. Niederst et al.   MOLECULAR BIOLOGY OF THE CELL

Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway

(2015) Utpal Das et al.   NATURE NEUROSCIENCE

A 3D human neural cell culture system for modeling Alzheimer's disease

(2015) Young Hye Kim et al.   Nature Protocols

Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage

(2015) Yohei Shibuya et al.   NEUROBIOLOGY OF AGING

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Inhibition of Protein Synthesis Alters Protein Degradation through Activation of Protein Kinase B (AKT)

(2013) Chun-Ling Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts

(2013) R. Bhattacharyya et al.   JOURNAL OF NEUROSCIENCE

In-depth proteomic analysis of mammalian mitochondria-associated membranes (MAM)

(2013) Chloe N. Poston et al.   Journal of Proteomics

Acat1 Knockdown Gene Therapy Decreases Amyloid-β in a Mouse Model of Alzheimer's Disease

(2013) Stephanie R Murphy et al.   MOLECULAR THERAPY

Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

(2013) Utpal Das et al.   NEURON

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Inhibition of endothelial cell Ca2+entry and transient receptor potential channels by Sigma-1 receptor ligands

(2012) Mohamed S Amer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system

(2012) Nicholas M. Kanaan et al.   EXPERIMENTAL NEUROLOGY

Mitochondria-associated ER membranes in Alzheimer disease

(2012) Eric A. Schon et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts

(2010) Marko Kosicek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ACAT inhibition and amyloid beta reduction

(2010) Raja Bhattacharyya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibitor CI-1011 Reverses Diffuse Brain Amyloid Pathology in Aged Amyloid Precursor Protein Transgenic Mice

(2010) Henri J. Huttunen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mitofusin 2 Is Necessary for Transport of Axonal Mitochondria and Interacts with the Miro/Milton Complex

(2010) A. Misko et al.   JOURNAL OF NEUROSCIENCE

Soft lithography for micro- and nanoscale patterning

(2010) Dong Qin et al.   Nature Protocols

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

(2010) E. Y. Bryleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid and Direct Transport of Cell Surface APP to the Lysosome defines a novel selective pathway

(2010) Angela Lorenzen et al.   Molecular Brain

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

(2009) Estela Area-Gomez et al.   AMERICAN JOURNAL OF PATHOLOGY

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway

(2009) Henri J. Huttunen et al.   FASEB JOURNAL

Structural and functional link between the mitochondrial network and the endoplasmic reticulum

(2009) Carlotta Giorgi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Cleavage Products of Amyloid-  Precursor Protein Are Sorted to Distinct Carrier Vesicles That Are Independently Transported within Neurites

(2009) V. Muresan et al.   JOURNAL OF NEUROSCIENCE

Synaptic Activity Reduces Intraneuronal A , Promotes APP Transport to Synapses, and Protects against A -Related Synaptic Alterations

(2009) D. Tampellini et al.   JOURNAL OF NEUROSCIENCE

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

(2009) Mariusz R Wieckowski et al.   Nature Protocols

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Alzheimer Disease Aβ Production in the Absence ofS-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts

(2008) Kulandaivelu S. Vetrivel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins

(2008) Tanuja T. Merianda et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON

Age-related decrease in axonal transport measured by MR imaging in vivo

(2007) Donna J. Cross et al.   NEUROIMAGE