Impact of Serum Proteins on the Uptake and RNA Interference Activity of N-Acetylgalactosamine-Conjugated Small Interfering RNAs

Pharmacokinetics and Pharmacodynamics of the Small Interfering Ribonucleic Acid (siRNA), Givosiran, in Patients with Acute Hepatic Porphyria

(2020) Sagar Agarwal et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Givosiran: First Approval

(2020) Lesley J. Scott   DRUGS

Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates

(2020) Christopher R Brown et al.   NUCLEIC ACIDS RESEARCH

Plasma and liver protein binding of GalNAc conjugated siRNA

(2019) Sara C Humphreys et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of electrophoretic mobility shift assay as a method to determine plasma protein binding of siRNA

(2019) Carrie Rocca et al.   Bioanalysis

Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression

(2018) Jennifer L.S. Willoughby et al.   MOLECULAR THERAPY

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

(2018) Donald J. Foster et al.   MOLECULAR THERAPY

Patisiran: First Global Approval

(2018) Sheridan M. Hoy   DRUGS

5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates

(2016) Rubina Parmar et al.   CHEMBIOCHEM

Asialoglycoprotein receptor mediated hepatocyte targeting — Strategies and applications

(2015) Anisha A. D'Souza et al.   JOURNAL OF CONTROLLED RELEASE

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hepatocytes clear platelets and are key regulators of disseminated intravascular coagulation during sepsis

(2009) Edouard Sanson et al.   JOURNAL OF HEPATOLOGY