Modulating Chemoselectivity in a Fe(II)/α-Ketoglutarate-Dependent Dioxygenase for the Oxidative Modification of a Nonproteinogenic Amino Acid

Exploring the biocatalytic potential of Fe/α‐ketoglutarate dependent halogenases

(2020) Moritz Voss et al.   CHEMISTRY-A EUROPEAN JOURNAL

Deciphering Pyrrolidine and Olefin Formation Mechanism in Kainic Acid Biosynthesis

(2020) Tzu-Yu Chen et al.   ACS Catalysis

Industrial Application of 2-Oxoglutarate-Dependent Oxygenases

(2019) Christin Peters et al.   Catalysts

Chemoenzymatic Total Synthesis of deoxy-, epi- and Podophyllotoxin and a Biocatalytic Kinetic Resolution of Dibenzylbutyrolactones

(2019) Mattia Lazzarotto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Chemoenzymatic Synthesis of (−)-Podophyllotoxin and Related Aryltetralin Lignans

(2019) Jian Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biochemical Characterization of a Multifunctional Mononuclear Nonheme Iron Enzyme (PtlD) in Neopentalenoketolactone Biosynthesis

(2019) Qian Deng et al.   ORGANIC LETTERS

Evolved Aliphatic Halogenases Enable Regiocomplementary C−H Functionalization of a Pharmaceutically Relevant Compound

(2019) Takahiro Hayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification and application of threonine aldolase for synthesis of valuable α-amino, β-hydroxy-building blocks

(2019) Mathieu Ligibel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation

(2018) Hsuan-Jen Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2-Oxoglutarate-Dependent Oxygenases

(2018) Md. Saiful Islam et al.   Annual Review of Biochemistry

Two Distinct Mechanisms for C–C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance

(2018) Noah P. Dunham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses

(2018) Shu-Shan Gao et al.   NATURAL PRODUCT REPORTS

Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases

(2018) Caitlyn Q Herr et al.   TRENDS IN BIOCHEMICAL SCIENCES

Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation

(2018) Yudai Matsuda et al.   Nature Communications

Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis

(2018) Yu Nakashima et al.   Nature Communications

Directed evolution of carbon–hydrogen bond activating enzymes

(2018) Raphael Frey et al.   CURRENT OPINION IN BIOTECHNOLOGY

Mechanistic Insights into the Decoupled Desaturation and Epoxidation Catalyzed by Dioxygenase AsqJ Involved in the Biosynthesis of Quinolone Alkaloids

(2017) Hao Su et al.   ACS Catalysis

Discovery of Key Dioxygenases that Diverged the Paraherquonin and Acetoxydehydroaustin Pathways in Penicillium brasilianum

(2016) Yudai Matsuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5

(2016) Andrew J Mitchell et al.   Nature Chemical Biology

The SWISS-MODEL Repository—new features and functionality

(2016) Stefan Bienert et al.   NUCLEIC ACIDS RESEARCH

Undirected, Homogeneous C–H Bond Functionalization: Challenges and Opportunities

(2016) John F. Hartwig et al.   ACS Central Science

Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases

(2015) Salette Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme

(2015) Wupeng Yan et al.   NATURE

Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi

(2015) Wenjing Li et al.   NUCLEIC ACIDS RESEARCH

Assembly of the unusual oxacycles in the orthosomycin antibiotics

(2015) Amie K. Boal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics

(2014) W.-c. Chang et al.   SCIENCE

Refined Regio- and Stereoselective Hydroxylation of l-Pipecolic Acid by Protein Engineering of l-Proline cis-4-Hydroxylase Based on the X-ray Crystal Structure

(2014) Kento Koketsu et al.   ACS Synthetic Biology

Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction

(2013) Wei-chen Chang et al.   NATURE

Adding Aliphatic C-H Bond Oxidations to Synthesis

(2012) M. C. White   SCIENCE

Characterization of novel 2-oxoglutarate dependent dioxygenases converting l-proline to cis-4-hydroxy-l-proline

(2009) Ryotaro Hara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FeII/α-ketoglutarate hydroxylases involved in nucleobase, nucleoside, nucleotide, and chromatin metabolism

(2008) Jana M. Simmons et al.   DALTON TRANSACTIONS

Theoretical Investigation of the Second-Shell Mechanism of Nitrile Hydratase

(2008) Kathrin H. Hopmann et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY