Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis

Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future

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Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

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Nanoparticle‐Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions

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Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

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MiR‐146a deletion protects from bone loss in OVX mice by suppressing RANKL/OPG and M‐CSF in bone microenvironment

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Monocyte/Macrophage Abnormalities Specific to Rheumatoid Arthritis Are Linked to miR-155 and Are Differentially Modulated by Different TNF Inhibitors

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Catalpol suppresses osteoclastogenesis and attenuates osteoclast-derived bone resorption by modulating PTEN activity

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Regulatory network mediated by RBP‐J/NFATc1‐miR182 controls inflammatory bone resorption

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Therapeutic effects of a TBK1 kinase inhibitor in germinal center-driven, autoantibody-mediated inflammatory arthritis

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Rheumatoid arthritis

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Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis

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Inhibition of osteoporosis by the αvβ3 integrin antagonist of rhodostomin variants

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Early Subchondral Bone Loss at Arthritis Onset Predicted Late Arthritis Severity in a Rat Arthritis Model

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Immunometabolism in early and late stages of rheumatoid arthritis

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The emerging safety profile of JAK inhibitors in rheumatic disease

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Graphene-Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization

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Critical role of CCL22/CCR4 axis in the maintenance of immune homeostasis during apoptotic cell clearance by splenic CD8α+CD103+dendritic cells

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Targeted delivery of low-dose dexamethasone using PCL–PEG micelles for effective treatment of rheumatoid arthritis

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LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

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RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis

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Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo

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Expression of chemokines CXCL4 and CXCL7 by synovial macrophages defines an early stage of rheumatoid arthritis

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Differential expression of pro-inflammatory cytokines IL-15Ralpha, IL-15, IL-6 and TNFalpha in synovial fluid from Rheumatoid arthritis patients

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Macrophage defense mechanisms against intracellular bacteria

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A safe and efficient hepatocyte-selective carrier system based on myristoylated preS1/21-47 domain of hepatitis B virus

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Successes and failures of chemokine-pathway targeting in rheumatoid arthritis

(2015) Zoltán Szekanecz et al.   Nature Reviews Rheumatology

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

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Tofacitinib

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Simultaneous NF-κB inhibition and E-cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHAin vitroandin vivo

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Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

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Alternative pathways of osteoclastogenesis in inflammatory arthritis

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Effects of CD14 Macrophages and Proinflammatory Cytokines on Chondrogenesis in Osteoarthritic Synovium-Derived Stem Cells

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Reduced apoptosis correlates with enhanced autophagy in synovial tissues of rheumatoid arthritis

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Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

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A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone

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Treatment of arthritis by macrophage depletion and immunomodulation: Testing an apoptosis-mediated therapy in a humanized death receptor mouse model

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Apoptosis: why and how does it occur in biology?

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Th17 Cells, Not IL-17+    T Cells, Drive Arthritic Bone Destruction in Mice and Humans

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A Central Role for CD68(+) Macrophages in Hepatopulmonary Syndrome

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Baseline RANKL:OPG ratio and markers of bone and cartilage degradation predict annual radiological progression over 11 years in rheumatoid arthritis

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No overall progression and occasional repair of erosions despite persistent inflammation in adalimumab-treated rheumatoid arthritis patients: results from a longitudinal comparative MRI, ultrasonography, CT and radiography study

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Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway

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Anti-inflammatory Agents: Present and Future

(2010) Charles A. Dinarello   CELL

Prevention and treatment of systemic glucocorticoid side effects

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Blimp1-mediated repression of negative regulators is required for osteoclast differentiation

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Effect of rituximab on physical function and quality of life in patients with rheumatoid arthritis previously untreated with methotrexate

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Bone remodeling in rheumatic disease: a question of balance

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18F-Labeled Galacto and PEGylated RGD Dimers for PET Imaging of αvβ3 Integrin Expression

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Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study

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