A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons

A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells

(2020) Yaroslav A. Kainov et al.   Nature Communications

ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair

(2019) Joseph R. Klim et al.   NATURE NEUROSCIENCE

Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration

(2019) Ze’ev Melamed et al.   NATURE NEUROSCIENCE

Regulation of Intronic Polyadenylation by PCF11 Impacts mRNA Expression of Long Genes

(2019) Ruijia Wang et al.   Cell Reports

U1 snRNP Telescripting: Suppression of Premature Transcription Termination in Introns as a New Layer of Gene Regulation

(2019) Christopher C. Venters et al.   Cold Spring Harbor Perspectives in Biology

Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis

(2019) Giulia E Tyzack et al.   BRAIN

Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs

(2019) Elisabetta Furlanis et al.   NATURE NEUROSCIENCE

Transcriptional Control by Premature Termination: A Forgotten Mechanism

(2019) Kinga Kamieniarz-Gdula et al.   TRENDS IN GENETICS

TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis

(2018) Jade-Emmanuelle Deshaies et al.   BRAIN

Dysregulation and Dislocation of SFPQ Disturbed DNA Organization in Alzheimer’s Disease and Frontotemporal Dementia

(2018) Jing Lu et al.   JOURNAL OF ALZHEIMERS DISEASE

Alternative 3′ UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments

(2018) Georgi Tushev et al.   NEURON

Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome

(2018) Roberta Cagnetta et al.   NEURON

Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

(2018) Raphaelle Luisier et al.   Nature Communications

Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain

(2018) Akihide Takeuchi et al.   Cell Reports

TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer’s disease

(2018) Sukriti Nag et al.   Acta Neuropathologica Communications

Efficient and Accurate Quantitative Profiling of Alternative Splicing Patterns of Any Complexity on a Laptop

(2018) Timothy Sterne-Weiler et al.   MOLECULAR CELL

A Developmental Program Truncates Long Transcripts to Temporally Regulate Cell Signaling

(2018) Jeremy E. Sandler et al.   DEVELOPMENTAL CELL

Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing

(2018) Lorea Blazquez et al.   MOLECULAR CELL

Alternative 3′ UTRs direct localization of functionally diverse protein isoforms in neuronal compartments

(2018) Camilla Ciolli Mattioli et al.   NUCLEIC ACIDS RESEARCH

SFPQ associates to LSD1 and regulates the migration of newborn pyramidal neurons in the developing cerebral cortex

(2017) K. Saud et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

U1 snRNP telescripting regulates a size–function-stratified human genome

(2017) Jung-Min Oh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development

(2017) Swapna Thomas-Jinu et al.   NEURON

Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq

(2017) Silvia Bottini et al.   Nature Communications

U1 snRNP telescripting regulates a size–function-stratified human genome

(2017) Jung-Min Oh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes

(2017) Shinsuke Ishigaki et al.   Cell Reports

Distal Alternative Last Exons Localize mRNAs to Neural Projections

(2016) J. Matthew Taliaferro et al.   MOLECULAR CELL

The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability

(2016) Katharina E Cosker et al.   NATURE NEUROSCIENCE

Lessons from non-canonical splicing

(2016) Christopher R. Sibley et al.   NATURE REVIEWS GENETICS

Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity

(2016) Oriane Mauger et al.   NEURON

The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold

(2016) Gavin J. Knott et al.   NUCLEIC ACIDS RESEARCH

Control of neuronal synapse specification by a highly dedicated alternative splicing program

(2016) L. Traunmuller et al.   SCIENCE

FUS-mediated regulation of alternative RNA processing in neurons: insights from global transcriptome analysis

(2016) Akio Masuda et al.   Wiley Interdisciplinary Reviews-RNA

The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site

(2015) Yongsheng Shi et al.   GENES & DEVELOPMENT

Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain

(2015) Guohao Wang et al.   Molecular Neurodegeneration

Recursive splicing in long vertebrate genes

(2015) Christopher R. Sibley et al.   NATURE

TRAP150 interacts with the RNA-binding domain of PSF and antagonizes splicing of numerous PSF-target genes in T cells

(2015) Christopher A. Yarosh et al.   NUCLEIC ACIDS RESEARCH

TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD

(2015) J. P. Ling et al.   SCIENCE

A Rare Motor Neuron Deleterious Missense Mutation in theDPYSL3(CRMP4) Gene is Associated with ALS

(2013) Hélène Blasco et al.   HUMAN MUTATION

A compendium of RNA-binding motifs for decoding gene regulation

(2013) Debashish Ray et al.   NATURE

Promoter directionality is controlled by U1 snRNP and polyadenylation signals

(2013) Albert E. Almada et al.   NATURE

Proteostasis in complex dendrites

(2013) Cyril Hanus et al.   NATURE REVIEWS NEUROSCIENCE

The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons

(2013) Christine E. Holt et al.   NEURON

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

U1 snRNP-mediated poly(A) site suppression

(2013) Jörg Langemeier et al.   RNA Biology

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention

(2012) K. Yap et al.   GENES & DEVELOPMENT

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

(2012) Annelies Van Hoecke et al.   NATURE MEDICINE

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Tau-Mediated Nuclear Depletion and Cytoplasmic Accumulation of SFPQ in Alzheimer's and Pick's Disease

(2012) Yazi Ke et al.   PLoS One

PHAST and RPHAST: phylogenetic analysis with space/time models

(2010) M. J. Hubisz et al.   BRIEFINGS IN BIOINFORMATICS

Morpholino artifacts provide pitfalls and reveal a novel role for pro-apoptotic genes in hindbrain boundary development

(2010) Sebastian S. Gerety et al.   DEVELOPMENTAL BIOLOGY

Phosphorylation-Dependent Regulation of PSF by GSK3 Controls CD45 Alternative Splicing

(2010) Florian Heyd et al.   MOLECULAR CELL

U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation

(2010) Daisuke Kaida et al.   NATURE

Fox-3 and PSF interact to activate neural cell-specific alternative splicing

(2010) Kee K. Kim et al.   NUCLEIC ACIDS RESEARCH

An active role for splicing in 3′-end formation

(2010) Harold G. Martinson   Wiley Interdisciplinary Reviews-RNA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Molecular Architecture of the Human Pre-mRNA 3′ Processing Complex

(2009) Yongsheng Shi et al.   MOLECULAR CELL

EphA4 and EfnB2a maintain rhombomere coherence by independently regulating intercalation of progenitor cells in the zebrafish neural keel

(2008) Hilary A. Kemp et al.   DEVELOPMENTAL BIOLOGY