RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

Phase 1 study of lenzilumab, a recombinant anti-human GM-CSF antibody, for chronic myelomonocytic leukemia (CMML)

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Clinical correlates, prognostic impact and survival outcomes in chronic myelomonocytic leukemia patients with the JAK2V617F mutation

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Suboptimal response rates to hypomethylating agent therapy in chronic myelomonocytic leukemia; a single institutional study of 121 patients

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Chronic myelomonocytic leukemia: 2018 update on diagnosis, risk stratification and management

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Phase I dose-escalation trial investigating volasertib as monotherapy or in combination with cytarabine in patients with relapsed/refractory acute myeloid leukaemia

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Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

(2018) Hiroyoshi Kunimoto et al.   CANCER CELL

Modeling ASXL1 mutation revealed impaired hematopoiesis caused by derepression of p16Ink4a through aberrant PRC1-mediated histone modification

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Blast phase chronic myelomonocytic leukemia: Mayo-MDACC collaborative study of 171 cases

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Unique dependence on Sos1 in KrasG12D-induced leukemogenesis

(2018) Xiaona You et al.   BLOOD

Ensembl 2018

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PLK1, A Potential Target for Cancer Therapy

(2017) Zhixian Liu et al.   Translational Oncology

KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions

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DNMT3A mutations are associated with inferior overall and leukemia-free survival in chronic myelomonocytic leukemia

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Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

(2016) Hartmut Döhner et al.   BLOOD

Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia

(2016) C. Elena et al.   BLOOD

When clinical heterogeneity exceeds genetic heterogeneity: thinking outside the genomic box in chronic myelomonocytic leukemia

(2016) M. Ball et al.   BLOOD

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

(2016) D. A. Arber et al.   BLOOD

Allogeneic hematopoietic stem cell transplant in adult patients with myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) overlap syndromes

(2016) Prashant Sharma et al.   LEUKEMIA & LYMPHOMA

Dynamics of clonal evolution in myelodysplastic syndromes

(2016) Hideki Makishima et al.   NATURE GENETICS

deepTools2: a next generation web server for deep-sequencing data analysis

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FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing

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Kras is Required for Adult Hematopoiesis

(2016) Alisa Damnernsawad et al.   STEM CELLS

Targeting WEE1 Kinase in Cancer

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Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents

(2016) Jane Merlevede et al.   Nature Communications

Cytogenetic and molecular abnormalities in chronic myelomonocytic leukemia

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Prognostic interaction between ASXL1 and TET2 mutations in chronic myelomonocytic leukemia

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Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

(2015) Dmitry Borkin et al.   CANCER CELL

Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid

(2015) Andrea Comba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-related mutations and chronic myelomonocytic leukemia

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Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network

(2015) Aurélie Caye et al.   NATURE GENETICS

The genomic landscape of juvenile myelomonocytic leukemia

(2015) Elliot Stieglitz et al.   NATURE GENETICS

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1–BAP1 complex

(2015) Anand Balasubramani et al.   Nature Communications

Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia

(2014) E. Stieglitz et al.   BLOOD

MAP-RSeq: Mayo Analysis Pipeline for RNA sequencing

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Volasertib for the treatment of acute myeloid leukemia: a review of preclinical and clinical development

(2014) Melanie Janning et al.   Future Oncology

Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy

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ASXL1 and SETBP1 mutations and their prognostic contribution in chronic myelomonocytic leukemia: a two-center study of 466 patients

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Targeting the wee1 kinase for treatment of pediatric Down syndrome acute myeloid leukemia

(2014) J. Timothy Caldwell et al.   PEDIATRIC BLOOD & CANCER

The RASopathies

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featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia

(2013) O. Abdel-Wahab et al.   BLOOD

GM-CSF-dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia

(2013) E. Padron et al.   BLOOD

Clonal architecture of chronic myelomonocytic leukemias

(2013) R. Itzykson et al.   BLOOD

Deciphering Hematopoietic Stem Cells in Their Niches: A Critical Appraisal of Genetic Models, Lineage Tracing, and Imaging Strategies

(2013) Chacko Joseph et al.   Cell Stem Cell

Prognostic Score Including Gene Mutations in Chronic Myelomonocytic Leukemia

(2013) Raphaël Itzykson et al.   JOURNAL OF CLINICAL ONCOLOGY

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

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ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression

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Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner

(2011) J. Wang et al.   BLOOD

A MEK-independent role for CRAF in mitosis and tumor progression

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Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus

(2010) Q. Li et al.   BLOOD

RAS Mutations Contribute to Evolution of Chronic Myelomonocytic Leukemia to the Proliferative Variant

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The NIH Roadmap Epigenomics Mapping Consortium

(2010) Bradley E Bernstein et al.   NATURE BIOTECHNOLOGY

The Sequence Alignment/Map format and SAMtools

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Fast and accurate short read alignment with Burrows-Wheeler transform

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edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

(2009) Ji Luo et al.   CELL

ConsensusPathDB—a database for integrating human functional interaction networks

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Model-based Analysis of ChIP-Seq (MACS)

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