Oleandrin, a cardiac glycoside, induces immunogenic cell death via the PERK/elF2α/ATF4/CHOP pathway in breast cancer

Oleandrin induces apoptosis via activating endoplasmic reticulum stress in breast cancer cells

(2020) Xiao-xi Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oleandrin: A bioactive phytochemical and potential cancer killer via multiple cellular signaling pathways

(2020) Nazia Kanwal et al.   FOOD AND CHEMICAL TOXICOLOGY

Cardiac glycosides inhibit cancer through Na/K-ATPase-dependent cell death induction

(2020) Xinran Geng et al.   BIOCHEMICAL PHARMACOLOGY

Targeting immunogenic cell death in cancer

(2020) Asma Ahmed et al.   Molecular Oncology

By binding CD80 and CD86, the vaccinia virus' M2 protein blocks their interactions with both CD28 and CTLA4 and potentiates CD80's binding to PD-L1

(2019) Patricia Kleinpeter et al.   JOURNAL OF VIROLOGY

Oleandrin sensitizes human osteosarcoma cells to cisplatin by preventing degradation of the copper transporter 1

(2019) Lei Yong et al.   PHYTOTHERAPY RESEARCH

Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences

(2019) Mara Cirone et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

(2019) Wei Li et al.   Nature Communications

Therapeutic landscape of metaplastic breast cancer

(2019) N. Tray et al.   CANCER TREATMENT REVIEWS

PKC signaling contributes to chromatin decondensation and is required for competence to respond to IL-2 during T cell activation

(2019) Jennifer R. Funsten et al.   CELLULAR IMMUNOLOGY

Cardenolides from the leaves of Nerium oleander

(2018) Yuan-Lin Cao et al.   FITOTERAPIA

Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance

(2018) Thomas Gebhardt et al.   IMMUNOLOGICAL REVIEWS

Interferon γ and Its Important Roles in Promoting and Inhibiting Spontaneous and Therapeutic Cancer Immunity

(2018) Elise Alspach et al.   Cold Spring Harbor Perspectives in Biology

Crosstalk between Na+,K+-ATPase and a volume-regulated anion channel in membrane microdomains of human cancer cells

(2018) Takuto Fujii et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resident memory T cells, critical components in tumor immunology

(2018) Fathia Mami-Chouaib et al.   Journal for ImmunoTherapy of Cancer

Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway

(2018) Young Ko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hydroalcoholic extract from Nerium oleander L. (Apocynaceae) elicits arrhythmogenic activity

(2017) Ana Flávia Machado Botelho et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Glycoside Oleandrin Reduces Glioma Growth with Direct and Indirect Effects on Tumor Cells

(2017) Stefano Garofalo et al.   JOURNAL OF NEUROSCIENCE

Targeting IL-10 Family Cytokines for the Treatment of Human Diseases

(2017) Xiaoting Wang et al.   Cold Spring Harbor Perspectives in Biology

Plant-derived cardiac glycosides: Role in heart ailments and cancer management

(2016) Seema Patel   BIOMEDICINE & PHARMACOTHERAPY

Response to Programmed Cell Death-1 Blockade in a Murine Melanoma Syngeneic Model Requires Costimulation, CD4, and CD8 T Cells

(2016) B. Homet Moreno et al.   Cancer Immunology Research

Cardiac glycosides induced toxicity in human cells expressing α1-, α2-, or α3-isoforms of Na-K-ATPase

(2015) Marina Cherniavsky Lev et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The endoplasmic reticulum: structure, function and response to cellular signaling

(2015) Dianne S. Schwarz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of oleandrin on the proliferation and invasion of osteosarcoma cells in vitro by suppressing Wnt/β-catenin signaling pathway

(2015) Yunlong Ma et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cardiac Glycosides from the Seeds of Thevetia peruviana

(2015) Dan-Mei Tian et al.   JOURNAL OF NATURAL PRODUCTS

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α

(2015) Margarito Rojas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chop deficiency prevents UUO-induced renal fibrosis by attenuating fibrotic signals originated from Hmgb1/TLR4/NFκB/IL-1β signaling

(2015) M Zhang et al.   Cell Death & Disease

Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade

(2014) S. J. Dovedi et al.   CANCER RESEARCH

First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf-κΒ and p70s6k, in patients with advanced solid tumors

(2014) D. S. Hong et al.   INVESTIGATIONAL NEW DRUGS

Evaluating the Cancer Therapeutic Potential of Cardiac Glycosides

(2014) José Manuel Calderón-Montaño et al.   Biomed Research International

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

Inducers of immunogenic cancer cell death

(2013) Aleksandra M. Dudek et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Predictive value of immunogenic cell death biomarkers HMGB1, sRAGE, and DNase in liver cancer patients receiving transarterial chemoembolization therapy

(2012) Nikolaus Kohles et al.   TUMOR BIOLOGY

Chemical Constituents of Plants from the Genus Nerium

(2010) Pallavi Sharma et al.   CHEMISTRY & BIODIVERSITY

Immunogenic Tumor Cell Death for Optimal Anticancer Therapy: The Calreticulin Exposure Pathway

(2010) L. Zitvogel et al.   CLINICAL CANCER RESEARCH

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Antiproliferative Activity of Derivatives of Ouabain, Digoxin and Proscillaridin A in Human MCF-7 and MDA-MB-231 Breast Cancer Cells

(2008) Katarzyna Winnicka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN