Discovery of De Novo Macrocyclic Peptides by Messenger RNA Display

Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages

(2020) Christos Tsiamantas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vitro Selection of Peptides and Proteins—Advantages of mRNA Display

(2020) Matilda S. Newton et al.   ACS Synthetic Biology

MOrPH-PhD: An Integrated Phage Display Platform for the Discovery of Functional Genetically Encoded Peptide Macrocycles

(2020) Andrew E. Owens et al.   ACS Central Science

Direct, Competitive Comparison of Linear, Monocyclic, and Bicyclic Libraries Using mRNA Display

(2020) David E. Hacker et al.   ACS Combinatorial Science

Ribosomal synthesis of backbone-cyclic peptides compatible with in vitro display

(2019) Ryo Takatsuji et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

De Novo Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease

(2019) Christoph Nitsche et al.   ACS Medicinal Chemistry Letters

Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges

(2019) Alexander A. Vinogradov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal Structures of Protein-Bound Cyclic Peptides

(2019) Alpeshkumar K. Malde et al.   CHEMICAL REVIEWS

Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor

(2019) Katsuya Sakai et al.   Nature Chemical Biology

De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains

(2019) Mickal Nawatha et al.   Nature Chemistry

DNA-Encoded Combinatorial Library of Macrocyclic Peptoids

(2019) Min Hyeon Shin et al.   BIOCONJUGATE CHEMISTRY

De Novo Carborane-Containing Macrocyclic Peptides Targeting Human Epidermal Growth Factor Receptor

(2019) Yizhen Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA-Encoded Chemical Libraries: A Selection System Based on Endowing Organic Compounds with Amplifiable Information

(2018) Dario Neri et al.   Annual Review of Biochemistry

Facile Synthesis of Dimeric Thioether–Macrocyclic Peptides with Antibody-like Affinity against Plexin-B1

(2018) Nasir K. Bashiruddin et al.   BIOCONJUGATE CHEMISTRY

Ribosomal synthesis and folding of peptide-helical aromatic foldamer hybrids

(2018) Joseph M. Rogers et al.   Nature Chemistry

Ribosomal Incorporation of Consecutive β-Amino Acids

(2018) Takayuki Katoh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RNA Display Methods for the Discovery of Bioactive Macrocycles

(2018) Yichao Huang et al.   CHEMICAL REVIEWS

Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist

(2018) Wenyu Miao et al.   Scientific Reports

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

(2017) Akane Kawamura et al.   Nature Communications

In Vivo Biosynthesis of a β-Amino Acid-Containing Protein

(2016) Clarissa Melo Czekster et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Twenty years on: the impact of fragments on drug discovery

(2016) Daniel A. Erlanson et al.   NATURE REVIEWS DRUG DISCOVERY

Coming of age: ten years of next-generation sequencing technologies

(2016) Sara Goodwin et al.   NATURE REVIEWS GENETICS

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes

(2015) Marta Pelay-Gimeno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein Synthesis with Ribosomes Selected for the Incorporation of β-Amino Acids

(2015) Rumit Maini et al.   BIOCHEMISTRY

Targeting protein−protein interfaces using macrocyclic peptides

(2015) Meng Gao et al.   BIOPOLYMERS

Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein Interactions

(2015) Teresa A. F. Cardote et al.   ChemMedChem

Encoded libraries of chemically modified peptides

(2015) Christian Heinis et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Macrocycles: lessons from the distant past, recent developments, and future directions

(2015) Andrei K. Yudin   Chemical Science

Constraining Cyclic Peptides To Mimic Protein Structure Motifs

(2014) Timothy A. Hill et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amino group binding peptide aptamers with double disulphide-bridged loops selected by in vitro selection using cDNA display

(2014) Yuki Mochizuki et al.   CHEMICAL COMMUNICATIONS

Structure-Based Virtual Screening for Drug Discovery: Principles, Applications and Recent Advances

(2014) Evanthia Lionta et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Peptides Containing β-Amino Acid Patterns: Challenges and Successes in Medicinal Chemistry

(2014) Chiara Cabrele et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ribosomal Synthesis of an Amphotericin-B Inspired Macrocycle

(2014) Kohei Torikai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reprogramming the genetic code in vitro

(2014) Toby Passioura et al.   TRENDS IN BIOCHEMICAL SCIENCES

Incorporation of β-amino acids into dihydrofolate reductase by ribosomes having modifications in the peptidyltransferase center

(2013) Rumit Maini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Improving Binding Affinity and Stability of Peptide Ligands by Substituting Glycines withD-Amino Acids

(2013) Shiyu Chen et al.   CHEMBIOCHEM

Discovery of Macrocyclic Peptides Armed with a Mechanism-Based Warhead: Isoform-Selective Inhibition of Human Deacetylase SIRT2

(2012) Jumpei Morimoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions

(2012) Jayanta Chatterjee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors

(2012) Yollete V. Guillen Schlippe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vitro Selection of Functional Lantipeptides

(2012) Frank T. Hofmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Puromycin Selection of Modified Ribosomes for in Vitro Incorporation of β-Amino Acids

(2011) Larisa M. Dedkova et al.   BIOCHEMISTRY

Natural Product-Like Macrocyclic N-Methyl-Peptide Inhibitors against a Ubiquitin Ligase Uncovered from a Ribosome-Expressed De Novo Library

(2011) Yusuke Yamagishi et al.   CHEMISTRY & BIOLOGY

Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery

(2011) Eric Marsault et al.   JOURNAL OF MEDICINAL CHEMISTRY

Flexizymes for genetic code reprogramming

(2011) Yuki Goto et al.   Nature Protocols

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

A flexizyme that selectively charges amino acids activated by a water-friendly leaving group

(2009) Nobuyoshi Niwa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

cDNA display: a novel screening method for functional disulfide-rich peptides by solid-phase synthesis and stabilization of mRNA-protein fusions

(2009) J. Yamaguchi et al.   NUCLEIC ACIDS RESEARCH

Reprogramming the Translation Initiation for the Synthesis of Physiologically Stable Cyclic Peptides

(2008) Yuki Goto et al.   ACS Chemical Biology

Polymerization of α-Hydroxy Acids by Ribosomes

(2008) Atsushi Ohta et al.   CHEMBIOCHEM

Messenger RNA-Programmed Incorporation of Multiple N-Methyl-Amino Acids into Linear and Cyclic Peptides

(2008) Takashi Kawakami et al.   CHEMISTRY & BIOLOGY

Ribosomal Synthesis of Polypeptoids and Peptoid−Peptide Hybrids

(2008) Takashi Kawakami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomal Synthesis of Bicyclic Peptides via Two Orthogonal Inter-Side-Chain Reactions

(2008) Yusuke Sako et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY