Little cells of the little brain: microglia in cerebellar development and function

Acute ethanol exposure rapidly alters cerebellar and cortical microglial physiology

(2020) Rianne D. Stowell et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome

(2020) Irune Diaz-Aparicio et al.   JOURNAL OF NEUROSCIENCE

Microglia Heterogeneity in the Single-Cell Era

(2020) Takahiro Masuda et al.   Cell Reports

Neuronal and glial regulation of CNS angiogenesis and barriergenesis

(2020) Saptarshi Biswas et al.   DEVELOPMENT

Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System

(2020) Patrick Süß et al.   Cell Reports

Human fetal microglia acquire homeostatic immune-sensing properties early in development

(2020) L. Kracht et al.   SCIENCE

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism

(2020) Lucas Cheadle et al.   NEURON

Astrocyte Heterogeneity: Impact to Brain Aging and Disease

(2019) Isadora Matias et al.   Frontiers in Aging Neuroscience

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

The Theory and Neuroscience of Cerebellar Cognition

(2019) Jeremy D. Schmahmann et al.   Annual Review of Neuroscience

A Working Hypothesis for the Role of the Cerebellum in Impulsivity and Compulsivity

(2019) Marta Miquel et al.   Frontiers in Behavioral Neuroscience

CSF-1 controls cerebellar microglia and is required for motor function and social interaction

(2019) Veronika Kana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

(2019) Georgia Gunner et al.   NATURE NEUROSCIENCE

Regulatory Control of Microglial Phagocytosis by Estradiol and Prostaglandin E2 in the Developing Rat Cerebellum

(2019) Miguel Perez-Pouchoulen et al.   CEREBELLUM

Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation

(2019) Masamichi Yamamoto et al.   Cell Reports

CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions

(2019) Courtney Easley-Neal et al.   Frontiers in Immunology

Mapping microglia states in the human brain through the integration of high-dimensional techniques

(2019) Roman Sankowski et al.   NATURE NEUROSCIENCE

Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex

(2019) Rianne D. Stowell et al.   NATURE NEUROSCIENCE

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Developmental alcohol exposure impairs synaptic plasticity without overtly altering microglial function in mouse visual cortex

(2018) Elissa L. Wong et al.   BRAIN BEHAVIOR AND IMMUNITY

Cerebellar microglia are dynamically unique and survey Purkinje neurons in vivo

(2018) Rianne D. Stowell et al.   Developmental Neurobiology

Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner

(2018) Moumita Datta et al.   IMMUNITY

Transcriptional Regulator ZEB2 Is Essential for Bergmann Glia Development

(2018) Li He et al.   JOURNAL OF NEUROSCIENCE

Author Correction: Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice

(2018) Catherine J. Stoodley et al.   NATURE NEUROSCIENCE

Epigenetic regulation of brain region-specific microglia clearance activity

(2018) Pinar Ayata et al.   NATURE NEUROSCIENCE

Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum

(2018) Hisako Nakayama et al.   Nature Communications

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

(2018) Laetitia Weinhard et al.   Nature Communications

P2Y12R-Dependent Translocation Mechanisms Gate the Changing Microglial Landscape

(2018) Ukpong B. Eyo et al.   Cell Reports

Microglia heterogeneity along a spatio-temporal axis: More questions than answers

(2018) Aymeric Silvin et al.   GLIA

Functional gradients of the cerebellum

(2018) Xavier Guell et al.   eLife

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors

(2018) Peter T. Tsai et al.   Cell Reports

The Emerging Role of Altered Cerebellar Synaptic Processing in Alzheimer’s Disease

(2018) Eriola Hoxha et al.   Frontiers in Aging Neuroscience

The microglial fractalkine receptor is not required for activity-dependent plasticity in the mouse visual system

(2017) Rebecca L. Lowery et al.   GLIA

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Proteomic analysis of aged microglia: shifts in transcription, bioenergetics, and nutrient response

(2017) Antwoine Flowers et al.   Journal of Neuroinflammation

In vivo deep two-photon imaging of neural circuits with the fluorescent Ca2+ indicator Cal-590

(2017) Carsten H. Tischbirek et al.   JOURNAL OF PHYSIOLOGY-LONDON

Heterogeneity in Synaptogenic Profile of Astrocytes from Different Brain Regions

(2017) Andrea Schmidt Buosi et al.   MOLECULAR NEUROBIOLOGY

Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: a multisite mega-analysis of 983 patients and 1349 healthy controls

(2017) T Moberget et al.   MOLECULAR PSYCHIATRY

Development and Refinement of Functional Properties of Adult-Born Neurons

(2017) Jenelle L. Wallace et al.   NEURON

Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia

(2017) Lindsay M. De Biase et al.   NEURON

Microglia Morphological Categorization in a Rat Model of Neuroinflammation by Hierarchical Cluster and Principal Components Analysis

(2017) María del Mar Fernández-Arjona et al.   Frontiers in Cellular Neuroscience

An updated assessment of microglia depletion: current concepts and future directions

(2017) Jinming Han et al.   Molecular Brain

Cerebellar gray matter differentiates children with early language delay in autism

(2016) Anila M. D'Mello et al.   Autism Research

Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor

(2016) Thomas Möller et al.   GLIA

Dark microglia: A new phenotype predominantly associated with pathological states

(2016) Kanchan Bisht et al.   GLIA

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

Astrocytes regulate heterogeneity of presynaptic strengths in hippocampal networks

(2016) Mathieu Letellier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

(2016) P. L. Stahl et al.   SCIENCE

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Microglia contact induces synapse formation in developing somatosensory cortex

(2016) Akiko Miyamoto et al.   Nature Communications

Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

(2016) G. O. Sipe et al.   Nature Communications

The Emotional Cerebellum

(2015) Piergiorgio Strata   CEREBELLUM

Consensus Paper: Cerebellar Development

(2015) Ketty Leto et al.   CEREBELLUM

Age- and location-related changes in microglial function

(2015) Rodney M. Ritzel et al.   NEUROBIOLOGY OF AGING

Anterograde C1ql1 Signaling Is Required in Order to Determine and Maintain a Single-Winner Climbing Fiber in the Mouse Cerebellum

(2015) Wataru Kakegawa et al.   NEURON

Reappraisal of Bergmann glial cells as modulators of cerebellar circuit function

(2015) Chris I. De Zeeuw et al.   Frontiers in Cellular Neuroscience

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Microglial CR3 Activation Triggers Long-Term Synaptic Depression in the Hippocampus via NADPH Oxidase

(2014) Jingfei Zhang et al.   NEURON

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain

(2014) N. Uesaka et al.   SCIENCE

Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism

(2014) Claire Piochon et al.   Nature Communications

Homeostatic and injury-induced microglia behavior in the aging brain

(2013) Jasmin K. Hefendehl et al.   AGING CELL

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

(2013) Claudia Jakubzick et al.   IMMUNITY

MHCII Is Required for  -Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneration

(2013) A. S. Harms et al.   JOURNAL OF NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Arc/Arg3.1 Is a Postsynaptic Mediator of Activity-Dependent Synapse Elimination in the Developing Cerebellum

(2013) Takayasu Mikuni et al.   NEURON

Origin, lineage and function of cerebellar glia

(2013) Annalisa Buffo et al.   PROGRESS IN NEUROBIOLOGY

Quantitating the subtleties of microglial morphology with fractal analysis

(2013) Audrey Karperien et al.   Frontiers in Cellular Neuroscience

The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation

(2012) Sayan Nandi et al.   DEVELOPMENTAL BIOLOGY

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Deficiency of the Microglial Receptor CX3CR1 Impairs Postnatal Functional Development of Thalamocortical Synapses in the Barrel Cortex

(2012) M. Hoshiko et al.   JOURNAL OF NEUROSCIENCE

Protocadherins mediate dendritic self-avoidance in the mammalian nervous system

(2012) Julie L. Lefebvre et al.   NATURE

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

GABAergic Inhibition Regulates Developmental Synapse Elimination in the Cerebellum

(2012) Hisako Nakayama et al.   NEURON

SK2 Channel Modulation Contributes to Compartment-Specific Dendritic Plasticity in Cerebellar Purkinje Cells

(2012) Gen Ohtsuki et al.   NEURON

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake

(2012) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age related changes in microglial phenotype vary between CNS regions: Grey versus white matter differences

(2011) Adam D. Hart et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia and Memory: Modulation by Early-Life Infection

(2011) L. L. Williamson et al.   JOURNAL OF NEUROSCIENCE

Remodeling of Monoplanar Purkinje Cell Dendrites during Cerebellar Circuit Formation

(2011) Megumi Kaneko et al.   PLoS One

Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum

(2011) K. Hashimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Camillo Golgi and Santiago Ramon y Cajal: The anatomical organization of the cortex of the cerebellum. Can the neuron doctrine still support our actual knowledge on the cerebellar structural arrangement?

(2010) Constantino Sotelo   BRAIN RESEARCH REVIEWS

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Intrinsic Plasticity Complements Long-Term Potentiation in Parallel Fiber Input Gain Control in Cerebellar Purkinje Cells

(2010) A. Belmeguenai et al.   JOURNAL OF NEUROSCIENCE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Neuronal Apoptosis in the Developing Cerebellum

(2010) X.-S. Cheng et al.   ANATOMIA HISTOLOGIA EMBRYOLOGIA

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Translocation of a “Winner” Climbing Fiber to the Purkinje Cell Dendrite and Subsequent Elimination of “Losers” from the Soma in Developing Cerebellum

(2009) Kouichi Hashimoto et al.   NEURON

Activity-dependent plasticity of developing climbing fiber–Purkinje cell synapses

(2009) L.W.J. Bosman et al.   NEUROSCIENCE

The Role of the Cerebellum in Schizophrenia

(2008) Nancy C. Andreasen et al.   BIOLOGICAL PSYCHIATRY

Bidirectional plasticity at developing climbing fiber-Purkinje neuron synapses

(2008) Gen Ohtsuki et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Morphogenesis and regulation of Bergmann glial processes during Purkinje cell dendritic spine ensheathment and synaptogenesis

(2008) Jocelyn J. Lippman et al.   GLIA

Alcohol Impairs Long-Term Depression at the Cerebellar Parallel Fiber–Purkinje Cell Synapse

(2008) Amor Belmeguenai et al.   JOURNAL OF NEUROPHYSIOLOGY

Tumor Necrosis Factor-α Mediates One Component of Competitive, Experience-Dependent Plasticity in Developing Visual Cortex

(2008) Megumi Kaneko et al.   NEURON

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

(2008) H. Lin et al.   SCIENCE