Rapamycin alleviates cognitive impairment in murine vascular dementia: The enhancement of mitophagy by PI3K/AKT/mTOR axis

Update on the Neurobiology of Vascular Cognitive Impairment: From Lab to Clinic

(2020) Luisa Vinciguerra et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acetyl-L-Carnitine in Dementia and Other Cognitive Disorders: A Critical Update

(2020) Manuela Pennisi et al.   Nutrients

Rapamycin and Alzheimer’s disease: Time for a clinical trial?

(2019) Matt Kaeberlein et al.   Science Translational Medicine

Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model

(2019) Andressa Manfredini et al.   CLINICAL SCIENCE

Effects of autophagy on synaptic-plasticity-related protein expression in the hippocampus CA1 of a rat model of vascular dementia

(2019) Bin Liu et al.   NEUROSCIENCE LETTERS

mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging

(2019) Candice E. Van Skike et al.   AGING CELL

Melatonin and Rapamycin Attenuate Isoflurane-Induced Cognitive Impairment Through Inhibition of Neuroinflammation by Suppressing the mTOR Signaling in the Hippocampus of Aged Mice

(2019) Hui Yuan et al.   Frontiers in Aging Neuroscience

Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment

(2019) Massimiliano Castellazzi et al.   Scientific Reports

FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia

(2018) Xin Jiang et al.   BEHAVIOURAL BRAIN RESEARCH

Early-onset subcortical ischemic vascular dementia in an adult with mtDNA mutation 3316G>A

(2018) Giuseppe Lanza et al.   JOURNAL OF NEUROLOGY

Rapamycin confers neuroprotection against aging-induced oxidative stress, mitochondrial dysfunction and neurodegeneration in old rats via activation of autophagy

(2018) Abhishek Kumar Singh et al.   REJUVENATION RESEARCH

Intracellular Delivery of Rapamycin From FKBP Elastin-Like Polypeptides Is Consistent With Macropinocytosis

(2018) Santosh Peddi et al.   Frontiers in Pharmacology

MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling

(2017) Alberto Bartolomé et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitophagy in neurodegeneration and aging

(2017) Elayne M. Fivenson et al.   NEUROCHEMISTRY INTERNATIONAL

Stroke injury, cognitive impairment and vascular dementia

(2016) Raj N. Kalaria et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cholinergic circuitry functioning in patients with vascular cognitive impairment – no dementia

(2016) Rita Bella et al.   Brain Stimulation

Rapamycin Protects Sepsis-Induced Cognitive Impairment in Mouse Hippocampus by Enhancing Autophagy

(2016) Wenyu Liu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

mTOR pathway inhibition prevents neuroinflammation and neuronal death in a mouse model of cerebral palsy

(2016) Isha N. Srivastava et al.   NEUROBIOLOGY OF DISEASE

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

(2015) Kenneth Maiese   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascular dementia

(2015) John T O'Brien et al.   LANCET

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Neuroprotective Effects ofClostridium butyricumagainst Vascular Dementia in Mice via Metabolic Butyrate

(2015) Jiaming Liu et al.   Biomed Research International

Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke

(2014) Qiang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway

(2014) Xuwei Hou et al.   Cardiovascular Diabetology

Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats

(2014) Bin Liu et al.   Neural Regeneration Research

mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

(2013) S. C. Johnson et al.   SCIENCE

Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for alzheimer's disease?

(2012) Zhiyou Cai et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Vascular dementia

(2012) Amos D. Korczyn et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion

(2012) Yeon Ja Choi et al.   PLoS One

Metabolic regulation by HMGB1-mediated autophagy and mitophagy

(2011) Rui Kang et al.   Autophagy

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Vascular Contributions to Cognitive Impairment and Dementia

(2011) Philip B. Gorelick et al.   STROKE

PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy

(2010) Sumihiro Kawajiri et al.   FEBS LETTERS

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Subchronic administration of rosmarinic acid, a natural prolyl oligopeptidase inhibitor, enhances cognitive performances

(2010) Dong Hyun Park et al.   FITOTERAPIA

The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin

(2010) Kostas Stylianou et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The multiple facets of mTOR in immunity

(2009) Thomas Weichhart et al.   TRENDS IN IMMUNOLOGY

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE