Cytosolic Delivery of Thiolated Mn‐cGAMP Nanovaccine to Enhance the Antitumor Immune Responses

Cytosolic Delivery of Thiolated Neoantigen Nano‐Vaccine Combined with Immune Checkpoint Blockade to Boost Anti‐Cancer T Cell Immunity

(2021) Da Zhang et al.   Advanced Science

ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity

(2020) John Alec Moral et al.   NATURE

Manganese-Based Nanoactivator Optimizes Cancer Immunotherapy via Enhancing Innate Immunity

(2020) Lin Hou et al.   ACS Nano

Ultrasound-Driven Biomimetic Nanosystem Suppresses Tumor Growth and Metastasis through Sonodynamic Therapy, CO Therapy, and Indoleamine 2,3-Dioxygenase Inhibition

(2020) Da Zhang et al.   ACS Nano

Co-delivery of Peptide Neoantigens and Stimulator of Interferon Genes Agonists Enhances Response to Cancer Vaccines

(2020) Daniel Shae et al.   ACS Nano

Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy

(2020) Xueguang Lu et al.   Science Translational Medicine

Self-assembled cGAMP-STINGΔTM signaling complex as a bioinspired platform for cGAMP delivery

(2020) Yanpu He et al.   Science Advances

Ag + ‐Coupled Black Phosphorus Vesicles with Emerging NIR‐II Photoacoustic Imaging Performance for Cancer Immune‐Dynamic Therapy and Fast Wound Healing

(2020) Zhi Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

(2020) Mengze Lv et al.   CELL RESEARCH

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

(2019) Daniel Shae et al.   Nature Nanotechnology

Drug developers switch gears to inhibit STING

(2019) Cormac Sheridan   NATURE BIOTECHNOLOGY

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

Self-Assembled and Size-Controllable Oligonucleotide Nanospheres for Effective Antisense Gene Delivery through an Endocytosis-Independent Pathway

(2019) Jie Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism

(2019) Juli Bai et al.   DIABETES

A microparticle platform for STING-targeted immunotherapy enhances natural killer cell- and CD8+ T cell-mediated anti-tumor immunity

(2019) Rebekah Watkins-Schulz et al.   BIOMATERIALS

STING Activation and its Application in Immuno-Oncology

(2019) Yiqian Lian et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Harnessing innate immunity in cancer therapy

(2019) Olivier Demaria et al.   NATURE

MHC-II neoantigens shape tumour immunity and response to immunotherapy

(2019) Elise Alspach et al.   NATURE

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Can innate immune system targets turn up the heat on 'cold' tumours?

(2018) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice

(2018) Morten K. Skouboe et al.   PLoS Pathogens

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

Biodegradable amino acid-based poly(ester amine) with tunable immunomodulating properties and their in vitro and in vivo wound healing studies in diabetic rats’ wounds

(2018) Mingyu He et al.   Acta Biomaterialia

Cancer immunotherapy

(2017) Eric Bender   NATURE

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

The immune contexture in cancer prognosis and treatment

(2017) Wolf H. Fridman et al.   Nature Reviews Clinical Oncology

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

(2016) Kelly D Moynihan et al.   NATURE MEDICINE

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Quantifying colocalization by correlation: The Pearson correlation coefficient is superior to the Mander's overlap coefficient

(2010) Jeremy Adler et al.   CYTOMETRY PART A

Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment

(2009) H. Harlin et al.   CANCER RESEARCH

Tumor-Specific T-Cell Memory: Clearing the Regulatory T-Cell Hurdle

(2008) A. L. Cote et al.   CANCER RESEARCH