DDAH2 suppresses RLR-MAVS–mediated innate antiviral immunity by stimulating nitric oxide–activated, Drp1-induced mitochondrial fission

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3

(2019) Xiaohan Ning et al.   MOLECULAR CELL

Mitochondrial fission requires DRP1 but not dynamins

(2019) Tiago Branco Fonseca et al.   NATURE

DDAH1 and DDAH2 polymorphisms associate with asymmetrical dimethylarginine plasma levels in erectile dysfunction patients but not in healthy controls

(2019) Guilhermo Brites-Anselmi et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor

(2019) Julien Lefranc et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nebivolol ameliorated kidney damage in Zucker diabetic fatty rats by regulation of oxidative stress/NO pathway: comparison with captopril

(2018) Yan Wang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Regulation of MAVS activation through post-translational modifications

(2018) Bingyu Liu et al.   CURRENT OPINION IN IMMUNOLOGY

Virus Infection Triggers MAVS Polymers of Distinct Molecular Weight

(2018) Natalia Zamorano Cuervo et al.   Viruses-Basel

The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways

(2017) Parimala R. Vajjhala et al.   MOLECULAR IMMUNOLOGY

Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy

(2017) Ana Maria Milanez Azevedo et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner

(2017) Run Fang et al.   PLoS Pathogens

S-Nitrosylation of DRP1 Does Not Affect Enzymatic Activity and is Not Specific to Alzheimer's Disease

(2017) Blaise Bossy et al.   JOURNAL OF ALZHEIMERS DISEASE

Dynamin-Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus

(2016) Shang-Der Chen et al.   CNS Neuroscience & Therapeutics

The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination

(2016) Bingyu Liu et al.   NATURE IMMUNOLOGY

Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase

(2016) Chiao‐Po Hsu et al.   Journal of the American Heart Association

Dimethylarginine Dimethylaminohydrolase 2 Regulates Nitric Oxide Synthesis and Hemodynamics and Determines Outcome in Polymicrobial Sepsis

(2015) S. Lambden et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Histone H3 Threonine Phosphorylation Regulates Asymmetric Histone Inheritance in the Drosophila Male Germline

(2015) Jing Xie et al.   CELL

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins

(2015) Chia-Yi Yu et al.   PLoS Pathogens

Pharmacology and Clinical Pharmacology of Methylarginines Used as Inhibitors of Nitric Oxide Synthases

(2014) Anja Kittel et al.   CURRENT PHARMACEUTICAL DESIGN

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

(2014) Delphine Goubau et al.   NATURE

Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence

(2014) S.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the prion-like MAVS filaments in antiviral innate immunity

(2014) Hui Xu et al.   eLife

Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

(2013) Len Verbeke et al.   HEPATOLOGY

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

(2013) Siqi Liu et al.   eLife

Nitric oxide release: Part II. Therapeutic applications

(2012) Alexis W. Carpenter et al.   CHEMICAL SOCIETY REVIEWS

Nitric Oxide Increases Susceptibility of Toll-like Receptor-Activated Macrophages to Spreading Listeria monocytogenes

(2012) Caroline Cole et al.   IMMUNITY

Dimethylarginine dimethylaminohydrolase 2, a newly identified mitochondrial protein modulating nitric oxide synthesis in normal human chondrocytes

(2011) Berta Cillero-Pastor et al.   ARTHRITIS AND RHEUMATISM

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Retinoic Acid-induced Gene-I (RIG-I) Associates with Nucleotide-binding Oligomerization Domain-2 (NOD2) to Negatively Regulate Inflammatory Signaling

(2011) Stefanie A. Morosky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Membrane Potential Is Required for MAVS-Mediated Antiviral Signaling

(2011) T. Koshiba et al.   Science Signaling

Retinoic acid inducible gene-I, more than a virus sensor

(2011) Feng Liu et al.   Protein & Cell

Mesenchymal stem cells improve murine acute coxsackievirus B3-induced myocarditis

(2010) S. Van Linthout et al.   EUROPEAN HEART JOURNAL

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Virus-Infection or 5′ppp-RNA Activates Antiviral Signal through Redistribution of IPS-1 Mediated by MFN1

(2010) Kazuhide Onoguchi et al.   PLoS Pathogens

Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

(2009) Céline Castanier et al.   EMBO REPORTS

Negative Regulation of MAVS-Mediated Innate Immune Response by PSMA7

(2009) Y. Jia et al.   JOURNAL OF IMMUNOLOGY

PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

(2009) Fuping You et al.   NATURE IMMUNOLOGY

RIG-I-like receptors: Sensing and responding to RNA virus infection

(2009) Peyman Nakhaei et al.   SEMINARS IN IMMUNOLOGY

The IKK-related kinases: from innate immunity to oncogenesis

(2008) Jean-François Clément et al.   CELL RESEARCH

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

Nitric oxide inhibits human rhinovirus-induced transcriptional activation of CXCL10 in airway epithelial cells

(2008) Rommy Koetzler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Chemical Inhibitor of DRP1 Uncouples Mitochondrial Fission and Apoptosis

(2008) Atsushi Tanaka et al.   MOLECULAR CELL

Are the IKKs and IKK-related kinases TBK1 and IKK-ɛ similarly activated?

(2008) Tieu-Lan Chau et al.   TRENDS IN BIOCHEMICAL SCIENCES