Thiamine-Diphosphate-Dependent Enzymes as Catalytic Tools for the Asymmetric Benzoin-Type Reaction

Enzymatic Chemoselective Aldehyde-Ketone Cross-Couplings through the Polarity Reversal of Methylacetoin

(2015) Giovanni Bernacchia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tuning and Switching Enantioselectivity of Asymmetric Carboligation in an Enzyme through Mutational Analysis of a Single Hot Spot

(2015) Cindy Wechsler et al.   CHEMBIOCHEM

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes

(2015) Darrin M. Flanigan et al.   CHEMICAL REVIEWS

Heterofunctional Magnetic Metal-Chelate-Epoxy Supports for the Purification and Covalent Immobilization of Benzoylformate Decarboxylase FromPseudomonas Putidaand Its Carboligation Reactivity

(2015) Servet Tural et al.   CHIRALITY

Combining a Clostridial Enzyme Exhibiting Unusual Active Site Plasticity with a Remarkably Facile Sigmatropic Rearrangement: Rapid, Stereocontrolled Entry into Densely Functionalized Fluorinated Phosphonates for Chemical Biology

(2015) Kaushik Panigrahi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Extended Reaction Scope of Thiamine Diphosphate Dependent Cyclohexane-1,2-dione Hydrolase: From CC Bond Cleavage to CC Bond Ligation

(2014) Sabrina Loschonsky et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Tailor-Made Chimeric Thiamine Diphosphate Dependent Enzyme for the Direct Asymmetric Synthesis of (S)-Benzoins

(2014) Robert Westphal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Scope of the Thiamine-Dependent Multifunctional Enzyme Cyclohexane-1,2-dione Hydrolase

(2014) Sabrina Loschonsky et al.   CHEMBIOCHEM

Elucidation of the Enantioselective Cyclohexane-1,2-dione Hydrolase Catalyzed Formation of (S )-Acetoin

(2014) Sabrina Loschonsky et al.   ChemCatChem

Expanding the scope of enzymatic carboligation reactions in flow-mode: production of optically active tertiary alcohols with packed-bed micro-bioreactors

(2014) P. P. Giovannini et al.   GREEN CHEMISTRY

Efficient 2-step biocatalytic strategies for the synthesis of all nor(pseudo)ephedrine isomers

(2014) Torsten Sehl et al.   GREEN CHEMISTRY

Benzaldehyde lyase (BAL)-catalyzed enantioselective CC bond formation in deep-eutectic-solvents–buffer mixtures

(2014) Zaira Maugeri et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

An overview of N-heterocyclic carbenes

(2014) Matthew N. Hopkinson et al.   NATURE

Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials

(2013) Torsten Sehl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MenD from Bacillus subtilis : A Potent Catalyst for the Enantiocomplementary Asymmetric Synthesis of Functionalized α-Hydroxy Ketones

(2013) Robert Westphal et al.   ChemCatChem

(S)-Selective MenD variants from Escherichia coli provide access to new functionalized chiral α-hydroxy ketones

(2013) Robert Westphal et al.   CHEMICAL COMMUNICATIONS

CC bond formation using ThDP-dependent lyases

(2013) Michael Müller et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Engineering stereoselectivity of ThDP-dependent enzymes

(2013) Helen C. Hailes et al.   FEBS Journal

Biocatalytic retrosynthesis

(2013) Nicholas J Turner et al.   Nature Chemical Biology

TCA Cycle Involved Enzymes SucA and Kgd, as well as MenD: Efficient Biocatalysts for Asymmetric C–C Bond Formation

(2013) Maryam Beigi et al.   ORGANIC LETTERS

Effective Production of (S)-α-Hydroxy ketones: An Reaction Engineering Approach

(2013) Álvaro Gómez Baraibar et al.   TOPICS IN CATALYSIS

Improving Transketolase

(2013) Adeline Ranoux et al.   TOPICS IN CATALYSIS

Influence of Organic Solvents on Enzymatic Asymmetric Carboligations

(2012) Tina Gerhards et al.   ADVANCED SYNTHESIS & CATALYSIS

Umpolung by N-Heterocyclic Carbenes: Generation and Reactivity of the Elusive 2,2-Diamino Enols (Breslow Intermediates)

(2012) Albrecht Berkessel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A pH-Based High-Throughput Assay for Transketolase: Fingerprinting of Substrate Tolerance and Quantitative Kinetics

(2012) Dong Yi et al.   CHEMBIOCHEM

An enzymatic approach to the synthesis of optically pure (3R)- and (3S)-enantiomers of green tea flavor compound 3-hydroxy-3-methylnonane-2,4-dione

(2012) Olga Bortolini et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

α-Hydroxy-β-keto acid rearrangement–decarboxylation: impact on thiamine diphosphate-dependent enzymatic transformations

(2012) Maryam Beigi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

S-Selective Mixed Carboligation by Structure-Based Design of the Pyruvate Decarboxylase from Acetobacter pasteurianus

(2011) Dörte Rother neé Gocke et al.   ChemCatChem

Functional Plasticity and Allosteric Regulation of α-Ketoglutarate Decarboxylase in Central Mycobacterial Metabolism

(2011) Tristan Wagner et al.   CHEMISTRY & BIOLOGY

Conversion of Pyruvate Decarboxylase into an Enantioselective Carboligase with Biosynthetic Potential

(2011) Danilo Meyer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Benzaldehyde lyase catalyzed enantioselective self and cross condensation reactions of acetaldehyde derivatives

(2011) Peruze Ayhan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enzymatic diastereo- and enantioselective synthesis of α-alkyl-α,β-dihydroxyketones

(2011) Pier Paolo Giovannini et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Switching Regioselectivity in Crossed Acyloin Condensations between Aromatic Aldehydes and Acetaldehyde by AlteringN-Heterocyclic Carbene Catalysts

(2011) Ming Yu Jin et al.   ORGANIC LETTERS

The Enzymatic Asymmetric Conjugate Umpolung Reaction

(2010) Carola Dresen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Intermolecular Aldehyde-Ketone Cross-Coupling through an Enzymatic Carboligation Reaction

(2010) Patrizia Lehwald et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

α,α′-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes

(2010) James L. Galman et al.   CHEMICAL COMMUNICATIONS

Bacillus stearothermophilus acetylacetoin synthase: A new catalyst for C–C bond formation

(2010) Pier Paolo Giovannini et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Highly Chemoselective Direct Crossed Aliphatic−Aromatic Acyloin Condensations with Triazolium-Derived Carbene Catalysts

(2010) Sarah E. O’Toole et al.   JOURNAL OF ORGANIC CHEMISTRY

Non-α-hydroxylated aldehydes with evolved transketolase enzymes

(2010) Armando Cázares et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Biocatalytic Strategies for the Asymmetric Synthesis of α-Hydroxy Ketones

(2009) Pilar Hoyos et al.   ACCOUNTS OF CHEMICAL RESEARCH

Propioin synthesis using thiamine diphosphate-dependent enzymes

(2009) Renaud J. Mikolajek et al.   BIOTECHNOLOGY PROGRESS

MenD as a versatile catalyst for asymmetric synthesis

(2009) Anja Kurutsch et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Cyclohexane-1,2-dione hydrolase: A new tool to degrade alicyclic compounds

(2009) Sonja Fraas et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Comparative characterisation of thiamin diphosphate-dependent decarboxylases

(2009) Dörte Gocke et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Highly Enantioselective Benzoin Condensation Reactions Involving a Bifunctional Protic Pentafluorophenyl-Substituted Triazolium Precatalyst

(2009) Louise Baragwanath et al.   JOURNAL OF ORGANIC CHEMISTRY

Enhancing and Reversing the Stereoselectivity ofEscherichia coliTransketolaseviaSingle-Point Mutations

(2008) Mark E. B. Smith et al.   ADVANCED SYNTHESIS & CATALYSIS

α,β-Unsaturated Aldehydes as Substrates for Asymmetric CC Bond Forming Reactions with Thiamin Diphosphate (ThDP)-Dependent Enzymes

(2008) Anabel Cosp et al.   ADVANCED SYNTHESIS & CATALYSIS

Rational Protein Design of ThDP-Dependent Enzymes—Engineering Stereoselectivity

(2008) Dörte Gocke et al.   CHEMBIOCHEM

Thiamin Diphosphate Catalysis: Enzymic and Nonenzymic Covalent Intermediates

(2008) Ronald Kluger et al.   CHEMICAL REVIEWS