Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia

Cyclotherapy: opening a therapeutic window in cancer treatment

(2015) Ingeborg M.M. van Leeuwen   Oncotarget

Pathobiology of chemotherapy-induced hair loss

(2013) Ralf Paus et al.   LANCET ONCOLOGY

Modifying chemotherapy response by targeted inhibition of eukaryotic initiation factor 4A

(2013) R Cencic et al.   Blood Cancer Journal

eIF4F suppression in breast cancer affects maintenance and progression

(2012) Z Nasr et al.   ONCOGENE

Targeting Synthetic Lethal Interactions between Myc and the eIF4F Complex Impedes Tumorigenesis

(2012) Chen-Ju Lin et al.   Cell Reports

A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation

(2011) Jane M Valentine et al.   BMC CANCER

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference

(2011) Prem K. Premsrirut et al.   CELL

Synthesis of Rocaglamide Hydroxamates and Related Compounds as Eukaryotic Translation Inhibitors: Synthetic and Biological Studies

(2011) Christina M. Rodrigo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatment

(2010) Sergey V Tokalov et al.   BMC CANCER

Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53

(2010) C F Cheok et al.   CELL DEATH AND DIFFERENTIATION

Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells

(2010) Fei-fei Zhou et al.   MEDICAL ONCOLOGY

Translating p53 into the clinic

(2010) Chit Fang Cheok et al.   Nature Reviews Clinical Oncology

Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F

(2010) R. Cencic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA damage response to the Mdm2 inhibitor Nutlin-3

(2009) Rajeev Verma et al.   BIOCHEMICAL PHARMACOLOGY

Altering Chemosensitivity by Modulating Translation Elongation

(2009) Francis Robert et al.   PLoS One

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

(2009) Regina Cencic et al.   PLoS One

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

(2009) S. Sur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-Myc and eIF4F Are Components of a Feedforward Loop that Links Transcription and Translation

(2008) C.-J. Lin et al.   CANCER RESEARCH

eIF4E knockdown decreases breast cancer cell growth without activating Akt signaling

(2008) A. Soni et al.   MOLECULAR CANCER THERAPEUTICS