Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular Aβ1–42 rat model of Alzheimer’s disease through modulations of hippocampal cAMP/cGMP/BDNF signaling pathway

Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer’s disease

(2020) Elisa Zuccarello et al.   BIOCHEMICAL PHARMACOLOGY

Glycogen synthase kinase-3 signaling in Alzheimer's disease

(2020) Elisabetta Lauretti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Neuroprotective role of alendronate against APP processing and neuroinflammation in mice fed a high fat diet

(2020) Saima Zameer et al.   BRAIN RESEARCH BULLETIN

Engeletin Attenuates Aβ1–42-Induced Oxidative Stress and Neuroinflammation by Keap1/Nrf2 Pathway

(2020) Zhixiong Huang et al.   INFLAMMATION

Roflumilast attenuates cognitive deficits in estrogen insufficient rats.

(2020) Ahsas Goyal et al.   BEHAVIOURAL PHARMACOLOGY

Sodium orthovanadate improves learning and memory in intracerebroventricular-streptozotocin rat model of Alzheimer’s disease through modulation of brain insulin resistance induced tau pathology

(2020) Ansab Akhtar et al.   BRAIN RESEARCH BULLETIN

Loss of Protection by Antiepileptic Drugs in Lipopolysaccharide-primed Pilocarpine-induced Status Epilepticus is Mediated via Inflammatory Signalling

(2020) Preeti Vyas et al.   NEUROSCIENCE

Tadalafil ameliorates memory deficits, oxidative stress, endothelial dysfunction and neuropathological changes in rat model of hyperhomocysteinemia induced vascular dementia

(2020) Pankaj Bhatia et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Roflumilast ameliorates cognitive impairment in APP/PS1 mice via cAMP/CREB/BDNF signaling and anti-neuroinflammatory effects

(2019) Huancun Feng et al.   METABOLIC BRAIN DISEASE

NMDA receptor in the hippocampus alters neurobehavioral phenotypes through inflammatory cytokines in rats with sporadic Alzheimer-like disease

(2019) Mohammad Amani et al.   PHYSIOLOGY & BEHAVIOR

Alpha lipoic acid and metformin alleviates experimentally induced insulin resistance and cognitive deficit by modulation of TLR2 signalling

(2019) Swati Ahuja et al.   Pharmacological Reports

Amyloid beta hypothesis in Alzheimer’s disease: Major culprits and recent therapeutic strategies

(2019) Dileep K. V. et al.   CURRENT DRUG TARGETS

Tadalafil restores long-term memory and synaptic plasticity in mice with hepatic encephalopathy

(2019) Maria Eduarda Rocha França et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MicroRNA‐134‐5p inhibition rescues long‐term plasticity and synaptic tagging/capture in an Aβ(1–42)‐induced model of Alzheimer’s disease

(2019) Nimmi Baby et al.   AGING CELL

Amentoflavone suppresses amyloid β1–42 neurotoxicity in Alzheimer's disease through the inhibition of pyroptosis

(2019) Ningning Zhao et al.   LIFE SCIENCES

Aging and Alzheimer's disease pathology

(2019) Renpei Sengoku   NEUROPATHOLOGY

Alzheimer’s disease paper 1: clinical update on epidemiology, pathophysiology and diagnosis

(2018) Dhamidhu Eratne et al.   Australasian Psychiatry

Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain

(2018) Michy P. Kelly   CELLULAR SIGNALLING

Protective effects of evodiamine in experimental paradigm of Alzheimer’s disease

(2018) Dongmei Wang et al.   Cognitive Neurodynamics

Betulinic acid, a natural PDE inhibitor restores hippocampal cAMP/cGMP and BDNF, improve cerebral blood flow and recover memory deficits in permanent BCCAO induced vascular dementia in rats

(2018) Madhu Kaundal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

(2018) Amanda Santiago et al.   NEUROPHARMACOLOGY

Sub-efficacious doses of phosphodiesterase 4 and 5 inhibitors improve memory in a mouse model of Alzheimer's disease

(2018) Walter Gulisano et al.   NEUROPHARMACOLOGY

Phosphodiesterase inhibition and modulation of corticostriatal and hippocampal circuits: Clinical overview and translational considerations

(2018) P.R.A. Heckman et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Protective effect of betulinic acid against intracerebroventricular streptozotocin induced cognitive impairment and neuronal damage in rats: Possible neurotransmitters and neuroinflammatory mechanism

(2018) Madhu Kaundal et al.   Pharmacological Reports

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

Tannins Enriched Fraction of Emblica officinalis Fruits Alleviates High-Salt and Cholesterol Diet-Induced Cognitive Impairment in Rats via Nrf2–ARE Pathway

(2018) Ibraheem Husain et al.   Frontiers in Pharmacology

Inhibition of Phosphodiesterase-4 Reverses Aβ-Induced Memory Impairment by Regulation of HPA Axis Related cAMP Signaling

(2018) Ying Xu et al.   Frontiers in Aging Neuroscience

NAP Protects against Tau Hyperphosphorylation Through GSK3

(2018) Yanina Ivashko-Pachima et al.   CURRENT PHARMACEUTICAL DESIGN

Ameliorative effect of alendronate against intracerebroventricular streptozotocin induced alteration in neurobehavioral, neuroinflammation and biochemical parameters with emphasis on Aβ and BACE-1

(2018) Saima Zameer et al.   NEUROTOXICOLOGY

An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patients

(2018) James Gilleen et al.   PSYCHOPHARMACOLOGY

Tetraclinis articulata essential oil mitigates cognitive deficits and brain oxidative stress in an Alzheimer's disease amyloidosis model

(2018) Fatima Zahra Sadiki et al.   PHYTOMEDICINE

Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by Aβ peptides in animal model of Alzheimer’s disease

(2018) Syed Obaidur Rahman et al.   BIOMEDICINE & PHARMACOTHERAPY

Lactuca capensis reverses memory deficits in Aβ1-42-induced an animal model of Alzheimer's disease

(2017) Paula Alexandra Postu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hyperglycemia and high nitric oxide level induced oxidative stress in the brain and molecular alteration in the neurons and glial cells of laboratory mouse, Mus musculus

(2017) Rashmi Richa et al.   NEUROCHEMISTRY INTERNATIONAL

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Caffeic acid attenuates oxidative stress, learning and memory deficit in intra-cerebroventricular streptozotocin induced experimental dementia in rats

(2016) Rahul Deshmukh et al.   BIOMEDICINE & PHARMACOTHERAPY

Cellular and molecular mechanisms of the brain-derived neurotrophic factor in physiological and pathological conditions

(2016) Veronica Begni et al.   CLINICAL SCIENCE

Alzheimer’s disease like pathology induced six weeks after aggregated amyloid-beta injection in rats: increased oxidative stress and impaired long-term memory with anxiety-like behavior

(2016) Sheetal Sharma et al.   NEUROLOGICAL RESEARCH

Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway

(2016) Yan-Juan Wang et al.   Oncotarget

Roflumilast: a review of its use in the treatment of COPD

(2016) Jadwiga Wedzicha et al.   International Journal of Chronic Obstructive Pulmonary Disease

Brain-derived neurotrophic factor and its clinical implications

(2015) Siresha Bathina et al.   Archives of Medical Science

Oxidant/Antioxidant Imbalance and the Risk of Alzheimer's Disease

(2015) Ahmed Moneim   Current Alzheimer Research

Lycopene abrogates Aβ(1–42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer’s disease

(2015) Anand Kamal Sachdeva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Object memory enhancement by combining sub-efficacious doses of specific phosphodiesterase inhibitors

(2015) E. Bollen et al.   NEUROPHARMACOLOGY

Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach

(2015) Andrew F. Teich et al.   Neurotherapeutics

Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40

(2014) Xiaoyan Hu et al.   Molecular Neurodegeneration

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

New insights concerning insulin synthesis and its secretion in rat hippocampus and cerebral cortex: Amyloid-β1–42-induced reduction of proinsulin level via glycogen synthase kinase-3β

(2013) Takayuki Nemoto et al.   CELLULAR SIGNALLING

Neuroprotective effect of tadalafil, a PDE-5 inhibitor, and its modulation by L-NAME in mouse model of ischemia-reperfusion injury

(2013) Puja Gulati et al.   JOURNAL OF SURGICAL RESEARCH

Memantine and Cholinesterase Inhibitors: Complementary Mechanisms in the Treatment of Alzheimer’s Disease

(2013) Chris G. Parsons et al.   NEUROTOXICITY RESEARCH

Benefits of combined cholinesterase inhibitor and memantine treatment in moderate–severe Alzheimer's disease

(2012) Serge Gauthier et al.   Alzheimers & Dementia

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

(2012) Philip T.T. Ly et al.   JOURNAL OF CLINICAL INVESTIGATION

BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease

(2012) Linda Chami et al.   Molecular Neurodegeneration

Tadalafil crosses the blood–brain barrier and reverses cognitive dysfunction in a mouse model of AD

(2012) Carolina García-Barroso et al.   NEUROPHARMACOLOGY

Cyclic AMP response element-binding protein (CREB) phosphorylation: A mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics

(2011) R. Scott Bitner   BIOCHEMICAL PHARMACOLOGY

Effects of sildenafil and tadalafil on ischemia/reperfusion injury in fetal rat brain

(2010) Ozlem Ozdegirmenci et al.   Journal of Maternal-Fetal & Neonatal Medicine

Preparation and characterization of toxic Aβ aggregates for structural and functional studies in Alzheimer's disease research

(2010) Asad Jan et al.   Nature Protocols

Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment

(2009) Francesca Mangialasche et al.   AGEING RESEARCH REVIEWS

The Ratio of Monomeric to Aggregated Forms of Aβ40 and Aβ42 Is an Important Determinant of Amyloid-β Aggregation, Fibrillogenesis, and Toxicity

(2008) Asad Jan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY