Mechanistic interplay of various mediators involved in mediating the neuroprotective effect of daphnetin

Daphnetin Ameliorates Experimental Autoimmune Encephalomyelitis Through Regulating Heme Oxygenase-1

(2020) Dan Wang et al.   NEUROCHEMICAL RESEARCH

The role of Toll-like receptor signaling pathways in cerebrovascular disorders: the impact of spreading depolarization

(2020) Rezan Ashayeri Ahmadabad et al.   Journal of Neuroinflammation

Daphnetin: A Novel Anti-Helicobacter pylori Agent

(2019) Genzhu Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chondroprotective and antiarthritic effects of daphnetin used in vitro and in vivo osteoarthritis models

(2019) Xiaohan Zhang et al.   LIFE SCIENCES

Daphnetin protects hippocampal neurons from oxygen-glucose deprivation-induced injury

(2018) Jin Zhi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Design and evaluation of selective butyrylcholinesterase inhibitors based on Cinchona alkaloid scaffold

(2018) Anita Bosak et al.   PLoS One

Activation of Nrf2/HO-1 Pathway by Nardochinoid C Inhibits Inflammation and Oxidative Stress in Lipopolysaccharide-Stimulated Macrophages

(2018) Jin-Fang Luo et al.   Frontiers in Pharmacology

Role of Microglia TLRs in Neurodegeneration

(2018) Bernd L. Fiebich et al.   Frontiers in Cellular Neuroscience

Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide ( t -BHP)-induced mitochondrial dysfunction and cell death

(2017) Hongming Lv et al.   FREE RADICAL BIOLOGY AND MEDICINE

Daphnetin reduces endotoxin lethality in mice and decreases LPS-induced inflammation in Raw264.7 cells via suppressing JAK/STATs activation and ROS production

(2017) Lei Shen et al.   INFLAMMATION RESEARCH

Meta-Analysis of Parkinson’s Disease and Alzheimer’s Disease Revealed Commonly Impaired Pathways and Dysregulation of NRF2-Dependent Genes

(2017) Qian Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response

(2017) Ji Yeon Seo et al.   MEDIATORS OF INFLAMMATION

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

(2017) Ana I. Rojo et al.   Redox Biology

Daphnetin Alleviates Experimental Autoimmune Encephalomyelitis via Regulating Dendritic Cell Activity

(2016) Dan Wang et al.   CNS Neuroscience & Therapeutics

Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration

(2016) Hongwei Qin et al.   JOURNAL OF NEUROSCIENCE

Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites

(2016) Si-Cheng Liang et al.   XENOBIOTICA

Anti-Alzheimer's disease potential of coumarins from Angelica decursiva and Artemisia capillaris and structure-activity analysis

(2016) Md. Yousof Ali et al.   Asian Pacific Journal of Tropical Medicine

Daphnetin protects oxidative stress-induced neuronal apoptosis via regulation of MAPK signaling and HSP70 expression

(2016) Zhilin Qi et al.   Oncology Letters

Ferulic Acid Regulates the Nrf2/Heme Oxygenase-1 System and Counteracts Trimethyltin-Induced Neuronal Damage in the Human Neuroblastoma Cell Line SH-SY5Y

(2016) Stefania Catino et al.   Frontiers in Pharmacology

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

(2016) Anja Henn   ALTEX-Alternatives to Animal Experimentation

Increased Alzheimer's disease–like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy

(2015) Gururaj Joshi et al.   NEUROBIOLOGY OF AGING

Different Roles of COMT and HTR2A Genotypes in Working Memory Subprocesses

(2015) Hirohito M. Kondo et al.   PLoS One

Calcium and ROS: A mutual interplay

(2015) Agnes Görlach et al.   Redox Biology

Forsythin inhibits lipopolysaccharide-induced inflammation by suppressing JAK-STAT and p38 MAPK signalings and ROS production

(2014) Xiaolong Pan et al.   INFLAMMATION RESEARCH

Daphnetin attenuates microglial activation and proinflammatory factor production via multiple signaling pathways

(2014) Wenwen Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Polyinosinic-Polycytidylic Acid Has Therapeutic Effects against Cerebral Ischemia/Reperfusion Injury through the Downregulation of TLR4 Signaling via TLR3

(2014) P.-F. Wang et al.   JOURNAL OF IMMUNOLOGY

Neuroprotective Effects of Daphnetin against NMDA Receptor-Mediated Excitotoxicity

(2014) Le Yang et al.   MOLECULES

Immunosuppressive Activity of Daphnetin, One of Coumarin Derivatives, Is Mediated through Suppression of NF-κB and NFAT Signaling Pathways in Mouse T Cells

(2014) Bocui Song et al.   PLoS One

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Therapeutic time window and underlying therapeutic mechanism of breviscapine injection against cerebral ischemia/reperfusion injury in rats

(2013) Chao Guo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Daphnetin, a Natural Coumarin Derivative, Provides the Neuroprotection Against Glutamate-Induced Toxicity in HT22 Cells and Ischemic Brain Injury

(2013) Gang Du et al.   NEUROCHEMICAL RESEARCH

Lack of BDNF expression through promoter IV disturbs expression of monoamine genes in the frontal cortex and hippocampus

(2013) K. Sakata et al.   NEUROSCIENCE

Review on Natural Coumarin Lead Compounds for Their Pharmacological Activity

(2013) K. N. Venugopala et al.   Biomed Research International

Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities ofβ-Carboline and Quinoline Alkaloids Derivatives from the Plants of GenusPeganum

(2013) Ting Zhao et al.   Journal of Chemistry

Daphnetin prevents chronic unpredictable stress-induced cognitive deficits

(2012) Min-Jing Liao et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis

(2012) Boris Sabirzhanov et al.   JOURNAL OF NEUROCHEMISTRY

The neurobiology and neural circuitry of cognitive changes in Parkinson's disease revealed by functional neuroimaging

(2012) Nicola J. Ray et al.   MOVEMENT DISORDERS

Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression

(2012) P. Licznerski et al.   NEUROSCIENCE

Neurotrophic effects of 7,8-dihydroxycoumarin in primary cultured rat cortical neurons

(2012) Li Yan et al.   Neuroscience Bulletin

Heat shock protein 70 together with its co-chaperone CHIP inhibits TNF-α induced apoptosis by promoting proteasomal degradation of apoptosis signal-regulating kinase1

(2010) Yanhong Gao et al.   APOPTOSIS

Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease

(2010) Malin von Otter et al.   BMC Medical Genetics

Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages

(2010) Amin Majdalawieh et al.   MEDIATORS OF INFLAMMATION

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

TLR4 Signaling Mediates Inflammation and Tissue Injury in Nephrotoxicity

(2008) B. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

(2008) Katja Kanninen et al.   MOLECULAR AND CELLULAR NEUROSCIENCE