Inactivation of TOPK Caused by Hyperglycemia Blocks Diabetic Heart Sensitivity to Sevoflurane Postconditioning by Impairing the PTEN/PI3K/Akt Signaling

Protective Effect of Resveratrol against Ischemia-Reperfusion Injury via Enhanced High Energy Compounds and eNOS-SIRT1 Expression in Type 2 Diabetic Female Rat Heart

(2019) Natacha Fourny et al.   Nutrients

Sevoflurane postconditioning is not mediated by ferritin accumulation and cannot be rescued by simvastatin in isolated streptozotocin-induced diabetic rat hearts

(2019) Hilbert Grievink et al.   PLoS One

Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway

(2019) Dawoud Sulaiman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions

(2019) Tian Liu et al.   Cancers

Sevoflurane postconditioning protects against myocardial ischemia/reperfusion injury by restoring autophagic flux via an NO-dependent mechanism

(2018) Shi-gang Qiao et al.   ACTA PHARMACOLOGICA SINICA

The role of microRNA-1 targeting MAPK3 in myocardial ischemia/reperfusion injury in rats undergoing sevoflurane preconditioning via the PI3K/Akt pathway

(2018) Yun-Ling Hao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

Trimetazidine protects against myocardial ischemia/reperfusion injury by inhibiting excessive autophagy

(2018) Shiyong Wu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

T-LAK cell-originated protein kinase (TOPK): an emerging target for cancer-specific therapeutics

(2018) Katharine J. Herbert et al.   Cell Death & Disease

Sevoflurane preconditioning during myocardial ischemia-reperfusion reduces infarct size and preserves autonomic control of circulation in rats

(2016) Rubens Campana Pasqualin et al.   Acta Cirurgica Brasileira

Diabetes blocks the cardioprotective effects of sevoflurane postconditioning by impairing Nrf2/Brg1/HO-1 signaling

(2016) Sumin Gao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Remote ischemic postconditioning protects against renal ischemia/reperfusion injury by activation of T-LAK-cell-originated protein kinase (TOPK)/PTEN/Akt signaling pathway mediated anti-oxidation and anti-inflammation

(2016) Sumin Gao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Off-pump versus on-pump coronary artery bypass surgery in patients with actively treated diabetes and multivessel coronary disease

(2016) Umberto Benedetto et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Sevoflurane postconditioning attenuates cardiomyocyte hypoxia/reoxygenation injury via restoring mitochondrial morphology

(2016) Jin Yu et al.   PeerJ

Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways

(2015) R. Xue et al.   CLINICAL SCIENCE

Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo

(2015) Mrinal Joel et al.   Molecular Cancer

Activation of T-LAK-cell-originated protein kinase-mediated antioxidation protects against focal cerebral ischemia-reperfusion injury

(2014) Haiping Zhao et al.   FEBS Journal

Ischemic Postconditioning Relieves Cerebral Ischemia and Reperfusion Injury Through Activating T-LAK Cell–Originated Protein Kinase/Protein Kinase B Pathway in Rats

(2014) Haiping Zhao et al.   STROKE

Sevoflurane Postconditioning Protects Rat Hearts against Ischemia-Reperfusion Injury via the Activation of PI3K/AKT/mTOR Signaling

(2014) Jing Zhang et al.   Scientific Reports

TOPK and PTEN participate in CHFR mediated mitotic checkpoint

(2013) Swapnil R. Shinde et al.   CELLULAR SIGNALLING

N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes

(2013) Tingting Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute hyperglycaemia enhances oxidative stress and aggravates myocardial ischaemia/reperfusion injury: role of thioredoxin-interacting protein

(2013) Hui Su et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Nitroglycerine-Induced Nitrate Tolerance Compromises Propofol Protection of the Endothelial Cells against TNF-α: The Role of PKC-β2and NADPH Oxidase

(2013) Shaoqing Lei et al.   Oxidative Medicine and Cellular Longevity

N-Acetylcysteine and Allopurinol Confer Synergy in Attenuating Myocardial Ischemia Injury via Restoring HIF-1α/HO-1 Signaling in Diabetic Rats

(2013) Xiaowen Mao et al.   PLoS One

Marked Hyperglycemia Attenuates Anesthetic Preconditioning in Human-induced Pluripotent Stem Cell-derived Cardiomyocytes

(2012) Scott G. Canfield et al.   ANESTHESIOLOGY

Novel TOPK Inhibitor HI-TOPK-032 Effectively Suppresses Colon Cancer Growth

(2012) D. J. Kim et al.   CANCER RESEARCH

Diabetes Blockade of Sevoflurane Postconditioning Is Not Restored by Insulin in the Rat Heart

(2011) Benjamin Drenger et al.   ANESTHESIOLOGY

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

TOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer

(2011) M-C Shih et al.   ONCOGENE

Critical roles of T-LAK cell-originated protein kinase in cytokinesis

(2009) Jae-Hyun Park et al.   CANCER SCIENCE

Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury

(2008) Hongmei Ruan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

NITRIC OXIDE TRIGGERS DELAYED ANESTHETIC PRECONDITIONING-INDUCED CARDIAC PROTECTION VIA ACTIVATION OF NUCLEAR FACTOR-κB AND UPREGULATION OF INDUCIBLE NITRIC OXIDE SYNTHASE

(2008) Chen Hsiu Chen et al.   SHOCK