Review
Oncology
Sitaram Harihar, Danny R. Welch
Summary: Current therapeutic approaches for metastatic cancers are ineffective at targeting dormant tumor cells, which are non-proliferative, growth-arrested, or resistant to therapy. The understanding of tumor dormancy has been limited, hindering progress in developing effective approaches. However, recent studies have identified KISS1 as a metastasis suppressor gene that keeps tumor cells in a dormant state. This review explores the mechanisms and potential application of KISS1 as a therapeutic for metastatic cancers by eliminating quiescent cells or inducing long-term dormancy.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Zhenxi Li, Jing Liu, Hiroyuki Inuzuka, Wenyi Wei
Summary: Kisspeptins, encoded by the KISS1 gene, play an important role in suppressing metastasis in certain types of cancers, but their physiological effects on cancer metastasis are context-dependent and still controversial. This article discusses the epigenetic mechanism regulating KISS1 gene expression, the context-dependent role of KISS1/KISS1R, the signaling pathways promoting or inhibiting metastasis, and the potential of targeting KISS1/KISS1R for anticancer therapeutics.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Review
Biology
Khulood M. Al-Khater, Sarah Almofty, Vijaya Ravinayagam, Noor Alrushaid, Suriya Rehman
Summary: Breast cancer is the most common cancer in females globally and metastasis, resistance to current drugs, and the role of metastatic suppressors like KAI1 are key challenges in managing the disease. Understanding the molecular events of genes like KAI1 is crucial for developing prognostic biomarkers and specific therapies for breast cancer patients.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Hong Liu, Chen Jin, Xia Yang, Nan Xia, Chunzhi Guo, Qian Dong
Summary: This study identified key genes of Wilms' tumor (WT) through bioinformatics analysis and validated the effects of AQP1 on cell invasion and migration in WT. Functional analysis highlighted the importance of cellular homeostasis and ion transport, revealing the regulatory network of key genes within cells.
Review
Gastroenterology & Hepatology
Arnav Bhattacharya, Anirudh Santhoshkumar, Hiroshi Kurahara, Sitaram Harihar
Summary: Pancreatic cancer, especially PDAC, has high mortality rates due to metastasis to multiple organs. Lack of efficient screening methods hinders effective therapeutic strategies. Understanding PDAC biology and metastasis suppressor genes could hold promise for treating this deadly cancer.
Review
Oncology
Irwin H. Gelman
Summary: Metastasis suppressor genes (MSG) are a class of genes that can suppress specific parameters of the metastatic cascade, with their expression typically being downregulated in metastasis. Therapeutic strategies targeting MSG by re-expressing them are being investigated to intervene in the formation and progression of metastases.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Medicine, Research & Experimental
Cho-Won Kim, Hong Kyu Lee, Min-Woo Nam, Gabsang Lee, Kyung-Chul Choi
Summary: This study found that KiSS1 overexpression increases the growth and migration of metastatic prostate cancer cells, as well as promoting tumor metastasis and angiogenesis. These findings highlight the critical role of KiSS1 in prostate cancer progression.
Article
Oncology
Dong-Mei Gan, Ping-Ping Zhang, Jian-Ping Zhang, Shu-Xia Ding, Jie Fang, Yang Liu
Summary: KISS1/KISS1R can regulate Sertoli cell apoptosis in male patients with diabetes, mediating protective effects through the PI3K/AKT signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Francisco M. Peinado, Alicia Olivas-Martinez, Inmaculada Lendinez, Luz M. Iribarne-Duran, Josefa Leon, Mariana F. Fernandez, Rafael Sotelo, Fernando Vela-Soria, Nicolas Olea, Carmen Freire, Olga Ocon-Hernandez, Francisco Artacho-Cordon
Summary: Increasing evidence suggests that exposure to endocrine-disrupting chemicals (EDCs), such as parabens and benzophenones, may play a role in the development and progression of endometriosis. This study investigated the expression profile of 23 genes related to crucial cell-signaling pathways in endometriotic tissue and their relationship with exposure to parabens and benzophenones. The findings showed that certain PB and BP congeners were positively associated with the expression of genes involved in the development and proliferation of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Biochemistry & Molecular Biology
Wan Li, Qingxia Wang, Xiaoyu Qi, Hongmei Lu, Yuheng Chen, Jiale Shi, Fei Wang, Ziyu Wang, Yao Lu, Zhongmou Lu, Qin Yan, Cong Wang, Shou-Jiang Gao, Chun Lu
Summary: A revised version of this paper has been published and is accessible through a link at the top of the paper.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Oncology
Rana S. Moubarak, Lisa Koetz-Ploch, Gavriel Mullokandov, Avital Gaziel, Ana De Pablos-Aragoneses, Diana Argibay, Kevin Kleffman, Elena Sokolova, Marianne Berwick, Nancy E. Thomas, Iman Osman, Brian D. Brown, Eva Hernando
Summary: Melanoma is a highly prevalent cancer with high metastatic potential. The study found that miR-124a plays a suppressive role in the metastasis of melanoma, especially in brain metastasis. Overexpression of miR-124a does not inhibit tumor growth but specifically controls the metastatic process of melanoma. miR-124a has the potential to be used as a therapeutic agent to impair melanoma metastatic growth and improve patient survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chan Wang, Jiaxin Chen, Yeye Kuang, Xiaoqing Cheng, Min Deng, Zhinong Jiang, Xiaotong Hu
Summary: The study found that TRPM4 is a novel methylated tumor suppressor gene that is downregulated in colorectal cancer. TRPM4 activates calpain-mediated cleavage of FAK through modulating the PI3K/Akt/mTOR signaling cascade, thereby impeding CRC migration and invasion.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Cho-Won Kim, Hong Kyu Lee, Min-Woo Nam, Youngdong Cho, Kyung-Chul Choi
Summary: KiSS1 promotes the proliferation, migration, and metastasis of liver cancer cells, which is associated with changes in the expressions of epithelial mesenchymal transition-related genes and increased angiogenic capacity.
MOLECULES AND CELLS
(2022)
Article
Medicine, General & Internal
Yanjie Hu, Liu Yang, Jie Zang, Sheng Wei, Lifeng Dong
Summary: The metastasis of breast cancer is a complex process involving multiple genes and steps. Common sites of breast cancer metastasis include the bone, lung, liver, and brain. We report a rare case of a 52-year-old woman with primary lobular carcinoma of the right breast showing small bowel and colon metastases. The regulation of metastasis-related genes serves as the molecular basis for tumor metastasis by promoting or inhibiting the potential of tumor spread.
ACTA MEDICA MEDITERRANEA
(2022)
Editorial Material
Oncology
Imran Khan, Patricia S. S. Steeg
Summary: Metastasis is the main cause of cancer patient mortality. Metastasis suppressors are genes that can significantly reduce metastasis without affecting the growth of the primary tumor when reexpressed in metastatic tumor cells. Analysis of more than 30 metastasis suppressors has revealed complex mechanisms of action, including multiple signaling pathways, transcriptional patterns, posttranscriptional regulatory mechanisms, and potential contributions of genomic stability. Clinical testing of strategies to re-establish a validated metastasis suppressor pathway in tumors is best directed to the adjuvant setting, with the goal of inhibiting the outgrowth of occult micrometastases.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Obstetrics & Gynecology
A. Sanozidis, T. Mikos, E. Assimakopoulos, A. Athanasiadis, T. Tantanassis, B. C. Tarlatzis, V. Papameletiou
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2018)
Article
Acoustics
G. T. Lainas, T. G. Lainas, C. A. Venetis, I. A. Sfontouris, I. Z. Zorzovilis, E. Alexopoulou, B. C. Tarlatzis, E. M. Kolibianakis
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2018)
Review
Obstetrics & Gynecology
Craig Niederberger, Antonio Pellicer, Jacques Cohen, David K. Gardner, Gianpiero D. Palermo, Claire L. O'Neill, Stephen Chow, Zev Rosenwaks, Ana Cobo, Jason E. Swain, William B. Schoolcraft, Rene Frydman, Lauren A. Bishop, Davora Aharon, Catherine Gordon, Erika New, Alan Decherney, Seang Lin Tan, Richard J. Paulson, James M. Goldfarb, Mats Brannstrom, Jacques Donnez, Sherman Silber, Marie-Madeleine Dolmans, Joe Leigh Simpson, Alan H. Handyside, Santiago Munne, Cristina Eguizabal, Nuria Montserrat, Juan Carlos Izpisua Belmonte, Alan Trounson, Carlos Simon, Togas Tulandi, Linda C. Giudice, Robert J. Norman, Aaron J. Hsueh, Yingpu Sun, Neri Laufer, Ronit Kochman, Talia Eldar-Geva, Bruno Lunenfeld, Diego Ezcurra, Thomas D'Hooghe, Bart C. J. M. Fauser, Basil C. Tarlatzis, David R. Meldrum, Robert F. Casper, Human M. Fatemi, Paul Devroey, Daniela Galliano, Matts Wikland, Mark Sigman, Richard A. Schoor, Marc Goldstein, Larry I. Lipshultz, Peter N. Schlegel, Alayman Hussein, Robert D. Oates, Robert E. Brannigan, Heather E. Ross, Guido Pennings, Susan C. Klock, Simon Brown, Andre Van Steirteghem, Robert W. Rebar, Andrew R. LaBarbera
FERTILITY AND STERILITY
(2018)
Article
Obstetrics & Gynecology
J. K. Bosdou, C. A. Venetis, B. C. Tarlatzis, G. F. Grimbizis, E. M. Kolibianakis
HUMAN REPRODUCTION
(2019)
Article
Cell Biology
Katerina Chatzimeletiou, Pierre Vanderzwalmen, Yannis Panagiotidis, Achilleas Papatheodorou, Alexandros Karagiannidis, Efstratios Kolibianakis, Grigoris Grimbizis, Nikos Prapas, Yannis Prapas, Basil C. Tarlatzis
Article
Endocrinology & Metabolism
Konstantinos Kotronis, Menelaos Zafrakas, Panayiota Papasozomenou, Anna Timologou, Dimosthenis Miliaras, Basil C. Tarlatzis, Grigorios Grimbizis
GYNECOLOGICAL ENDOCRINOLOGY
(2019)
Article
Reproductive Biology
Hatem A. Awaga, Stefania Lymperi, Julia K. Bosdou, Anastasios Makedos, Anna Mitsoli, Maria G. Bazioti, Despina Savvaidou, Dimitrios G. Goulis, Katerina Chatzimeletiou, Mohamed N. Salem, Salah R. Ahmed, Grigoris Grimbizis, Basil C. Tarlatzis, Efstratios M. Kolibianakis
REPRODUCTIVE BIOLOGY
(2019)
Article
Obstetrics & Gynecology
G. T. Lainas, T. G. Lainas, I. A. Sfontouris, K. Chatzimeletiou, C. A. Venetis, J. K. Bosdou, B. C. Tarlatzis, G. F. Grimbizis, E. M. Kolibianakis
HUMAN REPRODUCTION
(2019)
Review
Obstetrics & Gynecology
Maria Argyraki, Pauliina Damdimopoulou, Katerina Chatzimeletiou, Grigoris F. Grimbizis, Basil C. Tarlatzis, Maria Syrrou, Alexandros Lambropoulos
HUMAN REPRODUCTION UPDATE
(2019)
Article
Obstetrics & Gynecology
George T. Lainas, Tryfon G. Lainas, Ioannis A. Sfontouris, Christos A. Venetis, Julia K. Bosdou, Aikaterini Chatzimeletiou, Grigorios F. Grimbizis, Basil C. Tarlatzis, Efstratios M. Kolibianakis
REPRODUCTIVE BIOMEDICINE ONLINE
(2020)
Review
Obstetrics & Gynecology
Julia K. Bosdou, Panagiotis Anagnostis, Dimitrios G. Goulis, Georgios T. Lainas, Basil C. Tarlatzis, Grigoris F. Grimbizis, Efstratios M. Kolibianakis
HUMAN REPRODUCTION UPDATE
(2020)
Review
Genetics & Heredity
Glykeria I. Karatasiou, J. K. Bosdou, C. A. Venetis, L. Zepiridis, K. Chatzimeletiou, T. B. Tarlatzi, G. Lainas, B. C. Tarlatzis, G. Grimbizis, E. M. Kolibianakis
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Review
Biology
Paschalis Theotokis, Maria Eleni Manthou, Theodora-Eleftheria Deftereou, Dimosthenis Miliaras, Soultana Meditskou
Summary: Embryogenesis and fetal development are vulnerable to stress-associated factors such as space radiation and altered gravity, which can compromise normal physiological organogenesis. However, the effects of cosmic exposures on mammalian embryonic development are poorly understood. This review explores the impact of extraterrestrial conditions on histological level developmental adaptations observed in space simulations or actual expeditions, including the role of the vestibular system and the potential influence of the gut microbiome.
Article
Obstetrics & Gynecology
G. T. Lainas, T. G. Lainas, I. A. Sfontouris, C. A. Venetis, M. A. Kyprianou, G. K. Petsas, B. C. Tarlatzis, E. M. Kolibianakis
HUMAN REPRODUCTION OPEN
(2020)
Article
Oncology
I. C. Kotsopoulos, A. Papanikolaou, K. T. Papazisis, A. Hadzidimitriou, P. Touplikioti, D. Tsolalddisl, A. F. Lambropoulos, B. C. Tarlatzis
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
(2019)
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)