Article
Neurosciences
Yiyuan Yang, Mingzheng Wu, Abraham Vazquez-Guardado, Amy J. Wegener, Jose G. Grajales-Reyes, Yujun Deng, Taoyi Wang, Raudel Avila, Justin A. Moreno, Samuel Minkowicz, Vasin Dumrongprechachan, Jungyup Lee, Shuangyang Zhang, Alex A. Legaria, Yuhang Ma, Sunita Mehta, Daniel Franklin, Layne Hartmann, Wubin Bai, Mengdi Han, Hangbo Zhao, Wei Lu, Yongjoon Yu, Xing Sheng, Anthony Banks, Xinge Yu, Zoe R. Donaldson, Robert W. Gereau, Cameron H. Good, Zhaoqian Xie, Yonggang Huang, Yevgenia Kozorovitskiy, John A. Rogers
Summary: The authors introduce advanced technology for controlled wireless light delivery in optogenetics applications with real-time user programming capacity, demonstrating utility in inducing neural synchrony to modify social behavior in mice. Engineering studies of optoelectronic and thermal properties define capabilities and key design considerations of the wireless optogenetic platforms, highlighting the power of real-time subject-specific programmability.
NATURE NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Xue Cai, Lizhu Li, Wenhao Liu, Nianzhen Du, Yu Zhao, Yaning Han, Changbo Liu, Yan Yin, Xin Fu, Dawid Sheng, Lan Yin, Liping Wang, Pengfei Wei, Xing Sheng
Summary: Researchers have developed a wireless optoelectronic system for studying superior colliculus (SC), a structure related to defensive behaviors, in rodents using functional optogenetics.
Article
Computer Science, Information Systems
Lekshmy Sudha Kumari, Abbas Z. Kouzani
Summary: This paper presents a tetherless and miniaturized closed-loop optogenetic brain stimulation device for laboratory mice, which can sense biomarkers related to major depressive disorder and provide feedback to control the stimulation. The device is designed to address the issue of hindering the free movement of the animals caused by tethered devices in previous experiments.
Article
Automation & Control Systems
Finlay Walton, Eve McGlynn, Rupam Das, Hongze Zhong, Hadi Heidari, Patrick Degenaar
Summary: Electrical neurostimulation has a long history of success in both research and clinical settings. Optogenetics, a tool for precise genetic targeting of the stimulus, has become prominent in neuroscience. Magnetic stimulation complements optogenetics and together they offer a powerful and versatile tool for neural engineering.
ADVANCED INTELLIGENT SYSTEMS
(2022)
Review
Psychiatry
Shanshan Lin, Yiwei Du, Yujie Xia, Yumeng Xie, Ling Xiao, Gaohua Wang
Summary: Optogenetics is increasingly recognized as a novel technique for studying the neural circuit mechanisms underlying depression. Through systematic review of literature, researchers have demonstrated the potential of optogenetics in exploring neural circuits and investigating antidepressant treatment mechanisms. The rapid development of this technique suggests it may provide valuable insights into the etiology of depression and other psychiatric disorders in the future.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Quanyu Zhou, Zhenyue Chen, Yu-Hang Liu, Mohamad El Amki, Chaim Glueck, Jeanne Droux, Michael Reiss, Bruno Weber, Susanne Wegener, Daniel Razansky
Summary: Wide-field fluorescence imaging is a necessary tool for studying large-scale biodynamics. Conventional methods cannot provide high-resolution three-dimensional mapping. This study introduces a volumetric wide-field fluorescence microscopy based on optical astigmatism, which can map murine cortical microcirculation in real time and observe morphological and functional changes in cerebral vascular networks.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
James E. Niemeyer
Summary: This article utilizes new tools to study the dynamics of the whole brain during epileptic seizures originating in the hippocampus, revealing how various brain regions are recruited to seizures and uncovering a novel form of migrating seizure core.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Fangjing Yang, Fei Wang, Xingyi Ma, Mingjie Zhou, Su Jiang, Wendong Xu
Summary: This study investigates the long-term adaptations in the contralesional cortex after traumatic brain injury (TBI) using a mouse model and optogenetic mapping. The findings show that TBI does not affect the distribution of contralesional corticospinal neurons (CSNs), but alters their function, with labeled CSNs concentrated in the forelimb areas. This research provides new insights into utilizing contralesional cortical plasticity for improving motor control in TBI patients.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Chenghui Pi, Wenjing Tang, Zhishuai Li, Yang Liu, Qi Jing, Wei Dai, Tao Wang, Chunxiao Yang, Shengyuan Yu
Summary: This study established a minimally invasive optogenetic CSD model and identified the active networks after CSD using whole-brain activity mapping. The optogenetic CSD model showed behaviors mimicking headache and photophobia and activated multiple sensory cortical regions without involving the thalamus or trigeminal nucleus caudalis.
Article
Neurosciences
Russell W. Chan, Greg O. Cron, Mazen Asaad, Bradley J. Edelman, Hyun Joo Lee, Hillel Adesnik, David Feinberg, Jin Hyung Lee
Summary: This study investigates the circuitry of different layers within the primary motor cortex and reveals distinct responses in the brain when stimulating different layers. These findings contribute to a better understanding of how the primary motor cortex is embedded in the brain-wide circuitry.
Article
Neurosciences
Yi Ning Leow, Blake Zhou, Heather A. Sullivan, Alexandria R. Barlowe, Ian R. Wickersham, Mriganka Sur
Summary: The rodent homolog of the primate pulvinar, the lateral posterior thalamus, is interconnected with multiple cortical areas, particularly the anterior cingulate cortex (ACC). The ACC and lateral posterior thalamus receive inputs from various cortical and subcortical regions, playing a role in sensory processing, attentional regulation, and visuomotor functions. This study provides insights into the reciprocal interactions and information integration between ACC and lateral posterior thalamus.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Review
Pharmacology & Pharmacy
Jae Hee Lee, Sinjeong Lee, Daesoo Kim, Keon Jae Lee
Summary: Optogenetics is gaining attention in the biomedical field due to its precise control of time and space. Soft, flexible, and biocompatible systems using μLEDs as light sources have been developed for brain-compatible optogenetic implants, but there are still technical challenges to be overcome. This review discusses recent advancements in implantable μLED probes and their potential applications in various areas.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Mathematical & Computational Biology
Aditi Anand, Sanchari Sen, Kaushik Roy
Summary: Quantifying the similarity between artificial neural networks (ANNs) and biological counterparts is crucial for building more brain-like artificial intelligence systems. Recent research shows that a non-linear mapping function can lead to higher neural predictivity, but improvements in classification performance of image recognition ANNs do not necessarily translate to better neural predictivity.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2021)
Review
Neurosciences
Lekshmy Sudha Kumari, Abbas Z. Kouzani
Summary: Neural oscillations play a crucial role in brain function, with abnormalities in different frequency bands potentially causing cognitive and memory impairments. Researchers are using closed loop deep brain stimulation paradigms to investigate the mechanisms of these oscillations and how to manipulate brain stimulation strategies using oscillations as biomarkers.
Article
Environmental Sciences
Jiankai Di, Chunyong Ma, Ge Chen
Summary: The two-dimensional mapping of sea surface height for future wide-swath satellite altimetry is currently a challenge, with data-driven methods being a new research direction. The proposed Mapping-PNN method aims to improve training efficiency and maintain stable data and mapping capabilities. Experimental results show that this method can enhance training efficiency and meet grid mapping expectations, with a RMSE limited within approximately 1.8 cm, and promoting observation of ocean phenomena scale within 40 km.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Multidisciplinary Sciences
Katja Reinhard, Thomas A. Munch
Summary: The retinal output serves as the sole source of visual information for the brain, and research on ganglion cell types in human retinas has revealed a great diversity in light responses, potentially facilitating the interpretation of data from other primate species and laying the groundwork for the analysis of novel treatment approaches.
Article
Biochemical Research Methods
Clement Brunner, Micheline Grillet, Alan Urban, Botond Roska, Gabriel Montaldo, Emilie Mace
Summary: This protocol describes how to use functional ultrasound imaging to track brain-wide activity in awake head-fixed mice, including setting up the imaging system, establishing a cranial window, and extracting activity traces. Neuroscientists can observe global brain processes in mice using this method.
Article
Biochemistry & Molecular Biology
Elizabeth K. Wood, Dani P. Lemmon, Melanie L. Schwandt, Stephen G. Lindell, Christina S. Barr, Stephen J. Suomi, James Dee Higley
Summary: This study investigates the relationship between monoamine activity and alcohol intake using a nonhuman primate model. The results show that there is a positive correlation between monoamine metabolite concentrations and alcohol intake. Low serotonin and dopamine metabolite concentrations, as well as a smaller change in these metabolites, are associated with higher alcohol intake. On the other hand, low baseline norepinephrine metabolite concentrations and a greater change in these metabolites are also associated with higher alcohol intake.
Article
Neurosciences
Anwar O. Nunez-Elizalde, Michael Krumin, Charu Bai Reddy, Gabriel Montaldo, Alan Urban, Kenneth D. Harris, Matteo Carandini
Summary: Functional ultrasound imaging (fUSI) is an effective method for measuring blood flow and inferring brain activity, showing a strong correlation with slow fluctuations in neural firing rate. The study found that fUSI signals are accurately predicted by the smoothed firing rate of local neurons, particularly inhibitory neurons, and match neural firing spatially across different brain regions.
Article
Neurosciences
Clement Brunner, Emilie Mace, Gabriel Montaldo, Alan Urban
Summary: Researchers have developed a directional flow filter to accurately measure red blood cell velocity (RBCv) in small cortical vessels using functional ultrasound imaging without contrast agents. They observed a significant increase in RBCv in vessels during forepaw stimulation, with higher RBCv in penetrating arterioles located in the center of the activated area.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Neurosciences
Gabriel Montaldo, Alan Urban, Emilie Mace
Summary: This review introduces the principles, implementation, and applications of functional ultrasound, aiming to make the method accessible to all neuroscientists.
ANNUAL REVIEW OF NEUROSCIENCE
(2022)
Article
Cell Biology
An Beckers, Luca Masin, Annelies Van Dyck, Steven Bergmans, Sophie Vanhunsel, Anyi Zhang, Tine Verreet, Fabienne E. Poulain, Karl Farrow, Lieve Moons
Summary: This study reveals the phenomenon of mitochondrial shift between dendrites and axons during optic nerve injury-induced regeneration in zebrafish, and suggests that temporary changes in mitochondrial dynamics support axonal and dendritic regrowth after optic nerve crush.
NEURAL REGENERATION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Clement Brunner, Nielsen Lagumersindez Denis, Karen Gertz, Micheline Grillet, Gabriel Montaldo, Matthias Endres, Alan Urban
Summary: Ischemic stroke causes abrupt neurologic deficits and little is known about early hemodynamic changes in the brain. This study used functional ultrasound imaging to monitor relative cerebral blood volume (rCBV) variations after stroke onset in rats. Two stroke models were compared and a typical hemodynamic pattern was observed, with a drop in rCBV followed by reperfusion of nearby brain regions. The severity and location of the ischemia varied within the groups, with infarcts extending to non-ischemic regions associated with spreading depolarizations.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Multidisciplinary Sciences
Chen Li, Norma K. Kuhn, Ilayda Alkislar, Arnau Sans-Dublanc, Firdaouss Zemmouri, Soraya Paesmans, Alex Calzoni, Frederique Ooms, Katja Reinhard, Karl Farrow
Summary: Behavioral flexibility relies on the directed routing of sensory information. In the superior colliculus, inhibitory projection neurons projecting to different targets modulate responses to visual threats. By tracing neural connections and conducting recordings, it was found that these inhibitory neurons form separate populations projecting to the lateral geniculate nucleus (LGN) and the parabigeminal nucleus (PBG), receiving different inputs. Inhibiting LGN-projecting Gad2 neurons increased freezing behavior, while inhibiting PBG-projecting Gad2 neurons increased escaping behavior, indicating context-specific effects on behavior.