A lysine–cysteine redox switch with an NOS bridge regulates enzyme function

High-resolution crystal structures of two prototypical β- and γ-herpesviral nuclear egress complexes unravel the determinants of subfamily specificity

(2020) Yves A. Muller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved protein structure prediction using potentials from deep learning

(2020) Andrew W. Senior et al.   NATURE

Structural basis for antibiotic action of the B1 antivitamin 2′-methoxy-thiamine

(2020) Fabian Rabe von Pappenheim et al.   Nature Chemical Biology

‘It will change everything’: DeepMind’s AI makes gigantic leap in solving protein structures

(2020) Ewen Callaway   NATURE

Allosteric disulfides: Sophisticated molecular structures enabling flexible protein regulation

(2019) Joyce Chiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low-barrier hydrogen bonds in enzyme cooperativity

(2019) Shaobo Dai et al.   NATURE

Chemical proteomics reveals new targets of cysteine sulfinic acid reductase

(2018) Salma Akter et al.   Nature Chemical Biology

Crystallographic identification of spontaneous oxidation intermediates and products of protein sulfhydryl groups

(2018) Jimin Wang   PROTEIN SCIENCE

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Antimicrobial resistance in Neisseria gonorrhoeae: Global surveillance and a call for international collaborative action

(2017) Teodora Wi et al.   PLOS MEDICINE

Polder maps: improving OMIT maps by excluding bulk solvent

(2017) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

The coming of age of de novo protein design

(2016) Po-Ssu Huang et al.   NATURE

On methylene-bridged cysteine and lysine residues in proteins

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The Design of Covalent Allosteric Drugs

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Converting Transaldolase into Aldolase through Swapping of the Multifunctional Acid–Base Catalyst: Common and Divergent Catalytic Principles in F6P Aldolase and Transaldolase

(2015) Viktor Sautner et al.   BIOCHEMISTRY

Sweet siblings with different faces: The mechanisms of FBP and F6P aldolase, transaldolase, transketolase and phosphoketolase revisited in light of recent structural data

(2014) Kai Tittmann   BIOORGANIC CHEMISTRY

Marvels of enzyme catalysis at true atomic resolution: distortions, bond elongations, hidden flips, protonation states and atom identities

(2014) Piotr Neumann et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery

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Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs

(2013) Ron O. Dror et al.   NATURE

Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate

(2013) Stefan Lüdtke et al.   Nature Chemistry

Effect of the damping function in dispersion corrected density functional theory

(2011) Stefan Grimme et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism

(2011) Anja Lehwess-Litzmann et al.   Nature Chemical Biology

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Property-optimized Gaussian basis sets for molecular response calculations

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A Periplasmic Reducing System Protects Single Cysteine Residues from Oxidation

(2009) M. Depuydt et al.   SCIENCE