Evidence in primates supporting the use of chemogenetics for the treatment of human refractory neuropsychiatric disorders

Organization of primate amygdalar–thalamic pathways for emotions

(2020) Clare Timbie et al.   PLOS BIOLOGY

Amygdala-Midbrain Connections Modulate Appetitive and Aversive Learning

(2020) Elizabeth E. Steinberg et al.   NEURON

Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates

(2020) Nicholas A. Upright et al.   NEUROPSYCHOPHARMACOLOGY

Macaques Exhibit Implicit Gaze Bias Anticipating Others’ False-Belief-Driven Actions via Medial Prefrontal Cortex

(2020) Taketsugu Hayashi et al.   Cell Reports

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

(2020) Yuji Nagai et al.   NATURE NEUROSCIENCE

Altered Uncinate Fasciculus Microstructure in Childhood Anxiety Disorders in Boys But Not Girls

(2019) Do P.M. Tromp et al.   AMERICAN JOURNAL OF PSYCHIATRY

Ultrastructural localization of DREADD s in monkeys

(2019) Adriana Galvan et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Relationship Between the Uncinate Fasciculus and Anxious Temperament is Evolutionarily Conserved and Sexually Dimorphic

(2019) Do P.M. Tromp et al.   BIOLOGICAL PSYCHIATRY

Dorsal amygdala neurotrophin-3 decreases anxious temperament in primates

(2019) Andrew S. Fox et al.   BIOLOGICAL PSYCHIATRY

Trust, but verify: A cautionary tale of translating chemogenetic methods

(2019) J. Megan Fredericks et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Dynamic remodeling of a basolateral-to-central amygdala glutamatergic circuit across fear states

(2019) Nolan D. Hartley et al.   NATURE NEUROSCIENCE

High-potency ligands for DREADD imaging and activation in rodents and monkeys

(2019) Jordi Bonaventura et al.   Nature Communications

Behavioral Effect of Chemogenetic Inhibition Is Directly Related to Receptor Transduction Levels in Rhesus Monkeys

(2018) Nicholas A. Upright et al.   JOURNAL OF NEUROSCIENCE

Specificity of primate amygdalar pathways to hippocampus

(2018) Jingyi Wang et al.   JOURNAL OF NEUROSCIENCE

The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice

(2018) Daniel F. Manvich et al.   Scientific Reports

Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

(2017) Juan L. Gomez et al.   SCIENCE

Titer and Product Affect the Distribution of Gene Expression after Intraputaminal Convection-Enhanced Delivery

(2017) Marina E. Emborg et al.   STEREOTACTIC AND FUNCTIONAL NEUROSURGERY

Overexpressing Corticotropin-Releasing Factor in the Primate Amygdala Increases Anxious Temperament and Alters Its Neural Circuit

(2016) Ned H. Kalin et al.   BIOLOGICAL PSYCHIATRY

Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors

(2016) Bin Ji et al.   JOURNAL OF NEUROSCIENCE

The Rhesus Monkey Connectome Predicts Disrupted Functional Networks Resulting from Pharmacogenetic Inactivation of the Amygdala

(2016) David S. Grayson et al.   NEURON

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

The intercalated nuclear complex of the primate amygdala

(2016) Basilis Zikopoulos et al.   NEUROSCIENCE

PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation

(2016) Yuji Nagai et al.   Nature Communications

Complementary Patterns of Direct Amygdala and Hippocampal Projections to the Macaque Prefrontal Cortex

(2015) John P. Aggleton et al.   CEREBRAL CORTEX

From circuits to behaviour in the amygdala

(2015) Patricia H. Janak et al.   NATURE

Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value

(2015) Mark A G Eldridge et al.   NATURE NEUROSCIENCE

Intergenerational neural mediators of early-life anxious temperament

(2015) Andrew S. Fox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extending the amygdala in theories of threat processing

(2015) Andrew S. Fox et al.   TRENDS IN NEUROSCIENCES

Chemogenetic Tools to Interrogate Brain Functions

(2014) Scott M. Sternson et al.   Annual Review of Neuroscience

Differentially Methylated Plasticity Genes in the Amygdala of Young Primates Are Linked to Anxious Temperament, an at Risk Phenotype for Anxiety and Depressive Disorders

(2014) R. S. Alisch et al.   JOURNAL OF NEUROSCIENCE

Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety

(2014) R M Birn et al.   MOLECULAR PSYCHIATRY

Amygdala Microcircuits Controlling Learned Fear

(2014) Sevil Duvarci et al.   NEURON

Classics in Chemical Neuroscience: Clozapine

(2013) Cody J. Wenthur et al.   ACS Chemical Neuroscience

Neuropeptide Y Receptor Gene Expression in the Primate Amygdala Predicts Anxious Temperament and Brain Metabolism

(2013) Patrick H. Roseboom et al.   BIOLOGICAL PSYCHIATRY

BLA to vHPC Inputs Modulate Anxiety-Related Behaviors

(2013) Ada C. Felix-Ortiz et al.   NEURON

Neural mechanisms underlying heterogeneity in the presentation of anxious temperament

(2013) A. J. Shackman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel designer receptors to probe GPCR signaling and physiology

(2013) Jürgen Wess et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Lesions of Ventrolateral Prefrontal or Anterior Orbitofrontal Cortex in Primates Heighten Negative Emotion

(2012) Carmen Agustín-Pavón et al.   BIOLOGICAL PSYCHIATRY

Central amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates

(2012) A. S. Fox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amygdala circuitry mediating reversible and bidirectional control of anxiety

(2011) Kay M. Tye et al.   NATURE

Intraoperative Intracerebral MRI-Guided Navigation for Accurate Targeting in Nonhuman Primates

(2010) Marina E. Emborg et al.   CELL TRANSPLANTATION

Primates as a model for research

(2010) N. Garbarini   Disease Models & Mechanisms

Real-time MR Imaging With Gadoteridol Predicts Distribution of Transgenes After Convection-enhanced Delivery of AAV2 Vectors

(2010) Xiaomin Su et al.   MOLECULAR THERAPY

Amygdalar and hippocampal substrates of anxious temperament differ in their heritability

(2010) Jonathan A. Oler et al.   NATURE

A reproducible evaluation of ANTs similarity metric performance in brain image registration

(2010) Brian B. Avants et al.   NEUROIMAGE

Interneurons in the basolateral amygdala

(2010) Jay Spampanato et al.   NEUROPHARMACOLOGY

The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy

(2010) Prem N Yadav et al.   NEUROPSYCHOPHARMACOLOGY

Disrupted Amygdalar Subregion Functional Connectivity and Evidence of a Compensatory Network in Generalized Anxiety Disorder

(2009) Amit Etkin et al.   ARCHIVES OF GENERAL PSYCHIATRY

The optimal template effect in hippocampus studies of diseased populations

(2009) Brian B. Avants et al.   NEUROIMAGE

Amygdala Inhibitory Circuits and the Control of Fear Memory

(2009) Ingrid Ehrlich et al.   NEURON

Non-Human Primates: Model Animals for Developmental Psychopathology

(2008) Eric E Nelson et al.   NEUROPSYCHOPHARMACOLOGY

Trait-Like Brain Activity during Adolescence Predicts Anxious Temperament in Primates

(2008) Andrew S. Fox et al.   PLoS One

Behavioral and hormonal reactivity to threat: Effects of selective amygdala, hippocampal or orbital frontal lesions in monkeys

(2008) Christopher J. Machado et al.   PSYCHONEUROENDOCRINOLOGY