Article
Immunology
Hailong Dong, Bingxian Liu, Aoyun Li, Mudassar Iqbal, Khalid Mehmood, Tariq Jamil, Yung-Fu Chang, Hui Zhang, Qingxia Wu
Summary: Lactobacillus from yaks had a significant impact on the intestinal microbial community of mice, alleviating diarrhea by modulating gut microbiota. In mice supplemented with Lactobacillus, the proportion of Lactobacillus significantly increased, while the proportion of some pathogenic bacteria significantly decreased.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
C. L. Bao, S. Z. Liu, Z. D. Shang, Y. J. Liu, J. Wang, W. X. Zhang, B. Dong, Y. H. Cao
Summary: The study showed that Bacillus amyloliquefaciens TL106 can effectively protect mice against EHEC O157:H7 infection by relieving inflammation, improving intestinal barrier function, mitigating permeability disruption, and stabilizing the gut microbiota.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Biochemical Research Methods
Maxwell Neal, Deepan Thiruppathy, Karsten Zengler
Summary: This study developed a genome-scale metabolic model of B. fragilis strain 638R, providing a basis for understanding its relationship with human diet and metabolic products.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yongbin Li, Zhijia Fang, Xuewei Zhou, Jian Gao, Jingwen Wang, Linru Huang, Yinyan Chen, Lijun Sun, Qi Deng, Ravi Gooneratne
Summary: Cadmium (Cd) pollution in the environment poses a threat to human health as it can easily enter the body through the food chain. Gut microbiota, specifically Escherichia coli, has the potential to reduce Cd-induced intestinal damage and promote Cd excretion. Threonine (Thr) has been found to effectively increase fecal Cd and enhance the abundance of Escherichia-Shigella genus and KF843036_g, leading to reduced Cd accumulation in the liver, kidney, and gut of Cd-exposed mice.
Article
Biochemistry & Molecular Biology
Shunan Ren, Chunjie Wang, Aorigele Chen, Zhaoxing Bai, Yanping Tian, Wenting Lv
Summary: This study aimed to explore the anti-diarrheal activity of L. paracasei in a murine E. coli-induced diarrhea model by analyzing its intestinal metabolites and effects on the intestinal barrier. The results showed that oral administration of L. paracasei enhanced tight junction protein expression, alleviated clinical manifestations consistent with E. coli-induced diarrhea, and positively affected overall intestinal microecological homeostasis. Moreover, it increased the goblet cell count and the secretory immunoglobulin A content and regulated intestinal metabolism via gut microbes, thereby preventing E. coli-mediated disruption of the intestinal epithelial cell barrier.
Article
Food Science & Technology
Chi Chen, Yue Yue, Zhujun He, Bowen Li, Jianxin Zhao, Wei Chen, Bo Yang
Summary: This study compared the effects of five strains of Lactobacillus gasseri on ETEC-induced diarrhea and investigated their mechanisms. The results showed that three strains of L. gasseri could alleviate diarrhea by reducing inflammatory factors, normalizing gut microbiota, and producing short-chain fatty acids (SCFAs).
Article
Immunology
Jiayuan Cao, Qiqi Liu, Haining Hao, Yushan Bu, Xiaoying Tian, Ting Wang, Huaxi Yi
Summary: This study identified Lactobacillus paracasei X11 as a probiotic strain with uric acid-lowering activity. It effectively degraded nucleotides and nucleosides, regulated uric acid metabolism-related factors, and restored the ratio of intestinal microbiota in a mouse model of hyperuricemia. This suggests that L. paracasei X11 has the potential to be developed as a novel probiotic strain for the amelioration of hyperuricemia.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Meihui Cui, Tao Sun, Shubin Li, Huizhuo Pan, Jing Liu, Xinyu Zhang, Lianyue Li, Shanshan Li, Chunyang Wei, Chengzhuang Yu, Chun Yang, Ning Ma, Binglin Ma, Shenjunjie Lu, Jin Chang, Weiwen Zhang, Hanjie Wang
Summary: Recombinant bacterial colonization is essential in disease prevention, alleviation, and treatment, with the success of application hinges on efficient spatiotemporal colonization of host gut. The use of engineered upconversion microgels and light-responsive bacteria in this study demonstrated controlled and effective colonization of EcN, which successfully alleviated DSS-induced colitis in mice, potentially advancing the clinical application of engineered microbial therapeutics.
Article
Multidisciplinary Sciences
Yi Yang, Mytien Nguyen, Varnica Khetrapal, Nicole D. Sonnert, Anjelica L. Martin, Haiwei Chen, Martin A. Kriegel, Noah W. Palm
Summary: This study reveals that within-host evolution of gut commensal bacteria plays a critical role in bacterial translocation and initiation of inflammation. Gut microbiota strains can adapt and evolve, affecting their propensity to elicit inflammatory diseases. The changes in bacterial behavior are associated with genetic mutations, altered microbial gene expression programs, and remodelled cell wall structures.
Article
Multidisciplinary Sciences
Alexander Lin, Ching-Ting Shih, Hsu-Feng Chu, Chieh-Wen Chen, Yu-Ting Cheng, Chien-Chen Wu, Cheryl C. H. Yang, Ying-Chieh Tsai
Summary: PS150 effectively ameliorates sleep disturbances caused by unfamiliar environment, restoring NREM sleep duration and reducing sleep latency and time spent on restoring REM sleep without unwanted side effects. Additionally, it induces gut microbiota remodeling as revealed by 16S rRNA sequencing.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Matthew R. Volpe, Jose A. Velilla, Martin Daniel-Ivad, Jenny J. Yao, Alessia Stornetta, Peter W. Villalta, Hsin-Che Huang, Daniel A. Bachovchin, Silvia Balbo, Rachelle Gaudet, Emily P. Balskus
Summary: In this study, small molecule boronic acid inhibitors were developed to inhibit the biosynthesis of the human gut bacterial genotoxin colibactin. These inhibitors effectively block the genotoxic effects of colibactin on eukaryotic cells by engaging with the peptidase ClbP. The availability of these inhibitors allows for precise control over colibactin production, enabling further study of its contributions to colorectal cancer.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Zhibo Zeng, Zonghao Huang, Wen Yue, Shah Nawaz, Xinzhu Chen, Jing Liu
Summary: The administration of Lactobacillus plantarum has significant immunoenhancing effects in immunosuppressed mice, restoring specific immune markers in the spleen and increasing the number of goblet cells in the intestine. Microbial taxonomic analysis showed changes in the gut microbiota composition, with a decrease in Firmicutes and an increase in Verrucomicrobia and Actinobacteria. Additionally, treatment with Lactobacillus plantarum restored mRNA expression of inflammatory cytokines.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Tao Yang, Qijie Guan, Jin-Song Shi, Zheng-Hong Xu, Yan Geng
Summary: This study investigated whether metformin improves liver fibrosis in mice by enhancing the gut microbiota. The results showed that metformin treatment repaired the gut integrity and reduced bacteria and lipopolysaccharide levels in colon tissues. Fecal microbiota transplantation with the enriched Lactobacillus sp. MF-1 alleviated liver fibrosis. Mechanistically, metformin or L. sp. MF-1 inhibited intestinal epithelial cell apoptosis and restored immune function in the intestine and colon.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Anatoly V. Skalny, Michael Aschner, Xin Gen Lei, Viktor A. Gritsenko, Abel Santamaria, Svetlana I. Alekseenko, Nagaraja Tejo Prakash, Jung-Su Chang, Elena A. Sizova, Jane C. J. Chao, Jan Aaseth, Alexey A. Tinkov
Summary: The present study reviewed the association between Zn status and gut microbiota characteristics, as well as the potential role of Zn-induced microbiota in modulating systemic effects. The data showed a close relationship between Zn metabolism and gut microbiota, with Zn being a significant factor for gut bacteria biodiversity. Physiological and nutritional Zn doses improved gut wall integrity, while Zn overexposure induced substantial alterations in gut microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Fangjia Hao, Jiamin Zhu, Ning Zhang, Peng He, Qiandan Miao, Yumin Liu, Yu Gao, Xijian Liu, Guoying Deng, Zhong Zhang, Meiqing Feng, Linjing Zhao
Summary: This study investigated the metabolic changes in host-microbial co-metabolism and gut microbiome in mice after infection with carbapenem-resistant Escherichia coli (CRE). Significant alterations in metabolites were observed in the feces and serum of the CRE group, as well as changes in the relative abundance of certain bacterial taxa. Furthermore, association analyses revealed specific bacterial taxa associated with the changes in fecal and serum metabolites. This study offers insights into the early-stage interactions between gut microbiota and host metabolism during CRE infection, potentially leading to innovative diagnostic and therapeutic strategies.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)