Article
Gastroenterology & Hepatology
Shuxia Tian, Min Chen, Bing Wang, Yonglong Han, Haonan Shang, Junming Chen
Summary: This study identified that salvianolic acid B derived from Salvia miltiorrhiza can inhibit the proliferation and activation of hepatic stellate cells (HSCs) by regulating the FGF19/FGFR4 signaling pathway, demonstrating its anti-fibrotic effects in liver fibrosis.
ANNALS OF HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Hiroaki Kanzaki, Tetsuhiro Chiba, Junjie Ao, Keisuke Koroki, Kengo Kanayama, Susumu Maruta, Takahiro Maeda, Yuko Kusakabe, Kazufumi Kobayashi, Naoya Kanogawa, Soichiro Kiyono, Masato Nakamura, Takayuki Kondo, Tomoko Saito, Ryo Nakagawa, Sadahisa Ogasawara, Eiichiro Suzuki, Yoshihiko Ooka, Ryosuke Muroyama, Shingo Nakamoto, Shin Yasui, Akinobu Tawada, Makoto Arai, Tatsuo Kanda, Hitoshi Maruyama, Naoya Mimura, Jun Kato, Yoh Zen, Masayuki Ohtsuka, Atsushi Iwama, Naoya Kato
Summary: Inhibiting FGFR4/ERK signaling can enhance the efficacy of MKI treatment in HCC. Serum FGF19 levels may serve as a predictive marker for drug response and survival in HCC patients treated with sorafenib.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Ji-Yon Shin, Sung-Min Ahn
Summary: The study found that Src plays a crucial role in the endosomal delivery of the FGFR4 signaling complex in HCC. This provides a scientific rationale for repurposing Src inhibitors for the treatment of HCCs with activated FGFR4 pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Xiaolu Chen, Yanan Liu, Liting Zhang, Daoxing Chen, Zhaojun Dong, Chengguang Zhao, Zhiguo Liu, Qinqin Xia, Jianzhang Wu, Yongheng Chen, Xiaohui Zheng, Yuepiao Cai
Summary: In this study, a series of indazole derivatives were designed and synthesized, with F-30 showing subtle selectivity for FGFR4 and affecting cell growth and migration in HCC cell lines by inhibiting FGFR4 pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Xilang Chen, Jie Chen, Weibo Feng, Wenjie Huang, Guodong Wang, Mengyu Sun, Xiangyuan Luo, Yijun Wang, Yongzhan Nie, Daiming Fan, Kaichun Wu, Limin Xia
Summary: Elevated ELF4 expression is positively correlated with distant metastasis, advanced AJCC stages, and poor prognosis in colorectal cancer patients. ELF4 promotes CRC metastasis by transactivating its downstream target genes FGFR4 and SRC. FGF19 upregulates ELF4 expression through the ERK1/2/SP1 axis. Combination therapy with the FGFR4 inhibitor BLU-554 and the SRC inhibitor KX2-391 effectively suppresses ELF4-mediated CRC metastasis.
Article
Oncology
Xuesong Zhao, Jaya Julie Joshi, Daniel Aird, Craig Karr, Kun Yu, Chialing Huang, Federico Colombo, Milena Virrankoski, Sudeep Prajapati, Anand Selvaraj
Summary: The combination therapy of Lenvarinib and FGFR4 inhibitor shows enhanced efficacy for the treatment of FGF19-driven hepatocellular carcinoma by increasing anti-angiogenic and anti-tumorigenic activities.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Liwei Lang, Yuanping Xiong, Nestor Prieto-Dominguez, Reid Loveless, Caleb Jensen, Chloe Shay, Yong Teng
Summary: The study found that high-dose melatonin has dose-dependent effects on migration and invasion of head and neck squamous cell carcinoma cells. High-dose melatonin promotes cell metastasis through the FGF19/FGFR4 signaling pathway and reverses its anti-metastasis function. Blocking the FGF19/FGFR4 signaling pathway may enhance the efficacy of melatonin in cancer treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Youxi Yu, Xiaoju Shi, Qianqian Zheng, Xingtong Wang, Xingkai Liu, Min Tan, Guoyue Lv, Ping Zhang, Robert C. Martin, Yan Li
Summary: The study found that increased FGF15 in NASH-FGF21KO mice could not substitute for FGF21 to prevent NASH development. Up-regulated FGFR4 signaling in NASH-FGF21KO mice was associated with proliferation and epithelial-mesenchymal transition events, which are commonly linked to carcinogenic transformation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Leilei Wang, Yuxiong Su, Wing Shan Choi
Summary: The study showed that melatonin suppresses invasion and migration of OSCC cells by blocking the FGF19/FGFR4 pathway, suggesting a potential alternative for OSCCs prevention and management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tianli Chen, Hongda Liu, Zengli Liu, Kangshuai Li, Ruixi Qin, Yue Wang, Jialiang Liu, Zhipeng Li, Qinglun Gao, Chang Pan, Fan Yang, Wei Zhao, Zongli Zhang, Yunfei Xu
Summary: The study revealed that FGF19 and FGFR4 are adverse prognostic biomarkers for gallbladder carcinoma, with their co-expression being a more sensitive predictor. FGF19 can promote GBC progression by stimulating FGFR4 activation via an autocrine pathway with bile as a potential carrier.
Article
Oncology
Jianming Xu, Jiuwei Cui, Haiping Jiang, Yan Zeng, Xiuyu Cong
Summary: This study determined the MTD, RP2D, pharmacokinetics, safety, and preliminary efficacy of EVER4010001 plus pembrolizumab in patients with advanced solid tumors. The results showed that 80 mg BID was the MTD and RP2D for EVER4010001 plus pembrolizumab.
Article
Endocrinology & Metabolism
Einat Blitz, Hiroki Matsuda, Stefan Guenther, Takuto Morikawa, Yukihiko Kubota, David Zada, Tali Lerer-Goldshtein, Didier Y. R. Stainier, Lior Appelbaum
Summary: Hypothyroidism is characterized by insufficient thyroid hormone activity, leading to reduced goblet cells in the intestine, which can be rescued by T3 treatment. Transcriptome profiling revealed differential gene expression in the intestine of hypothyroid adults, with Fgf19-Fgfr4 signaling pathway being associated with inhibition of goblet cell differentiation in hypothyroidism. Targeting the TH and Fgf19-Fgfr4 signaling pathways could be a potential treatment for TH-related gastro-intestinal diseases.
Article
Oncology
Yanshuang Zhang, Tingyu Wu, Yuting Wang, Zhuo Chen, Jiachen Chen, Shun Lu, Weiliang Xia
Summary: In this study, the researchers discovered a signaling interaction between FGF19 and GLI2 that plays a crucial role in the invasion and metastasis of metastatic lung squamous cell carcinoma (LUSC). They found that FGF19 and GLI2 form a positive feedback loop to promote LUSC cell invasion and metastasis, and intervening with this loop may be a strategy for treating FGF19-driven LUSC metastasis.
Article
Cardiac & Cardiovascular Systems
Hiroshi Kishimoto, Toshiaki Nakano, Kumiko Torisu, Masanori Tokumoto, Yushi Uchida, Shunsuke Yamada, Masatomo Taniguchi, Takanari Kitazono
Summary: This study found that Indoxyl Sulfate (IS) increases fibroblast growth factor 23 (FGF23) protein expression through upregulation of polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) and hypoxia-inducible factor 1 alpha expression. Meanwhile, IS activates the FGF23-FGFR4 signaling pathway in cardiomyocytes, leading to left ventricular hypertrophy (LVH).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Chemistry, Medicinal
Bo Fang, Yinshuang Lai, Hao Yan, Yue Ma, Zefeng Ni, Qianqian Zhu, Jianxia Zhang, Yanfei Ye, Mengying Wang, Peipei Wang, Yan Wang, Shuyuan Zhang, Min Hui, Dalong Wang, Yunjie Zhao, Xiaokun Li, Kun Wang, Zhiguo Liu
Summary: Aberrant FGFR4 signaling is implicated in cancer development, and this study reports a novel series of selective inhibitors targeting FGFR4 kinase. Compound 19g showed excellent kinase selectivity and cytotoxicity against colorectal cancer cell lines. It also demonstrated significant tumor inhibition in a mouse model and disrupted FGFR4 phosphorylation and downstream signaling. Compound 19g could be a potential candidate for colorectal cancer treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Plant Sciences
Fei Xiao, Huayue Li, Mingyuan Xu, Tong Li, Ju Wang, Chaomin Sun, Kui Hong, Wenli Li
JOURNAL OF NATURAL PRODUCTS
(2018)
Article
Chemistry, Medicinal
Ju Wang, Ge Liu, Weiping Ma, Zhongxia Lu, Chaomin Sun
Article
Biochemistry & Molecular Biology
Ge Liu, Shan Kuang, Ruobing Cao, Ju Wang, Quancai Peng, Chaomin Sun
Article
Ecology
Jing Zhang, Rui Liu, Shichuan Xi, Ruining Cai, Xin Zhang, Chaomin Sun
Article
Microbiology
Rui Liu, Rikuan Zheng, Ge Liu, Chaomin Sun
ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Shengnan Zhou, Ge Liu, Rikuan Zheng, Chaomin Sun, Shimei Wu
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Microbiology
Ning Ma, Zhongli Sha, Chaomin Sun
Summary: The addition of cysteine enhances the Cd tolerance and removal efficiency of deep-sea bacterium Idiomarina sp. OT37-5b, leading to the formation of CdS nanoparticles which promote nitrogen reduction and energy production. The presence of CdS nanoparticles significantly boosts the growth and energy utilization of the bacterium under light exposure.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Microbiology
Zuodong Wu, Rikuan Zheng, Ge Liu, Rui Liu, Shimei Wu, Chaomin Sun
Summary: The marine bacterium Bacillus sp. 98 has evolved a strategy to alleviate Cd-toxicity by recruiting calcium to reduce intracellular nitric oxide and enhance iron acquisition. Proteomic analysis revealed that the expression of NO synthase was down-regulated while NO dioxygenase and iron uptake proteins were up-regulated when calcium was supplemented. Additionally, calcium protected bacteria against stresses from other heavy metals and this strategy was also observed in zebrafish, suggesting potential for developing calcium-associated products against heavy metals toxicity in the future.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Microbiology
Rikuan Zheng, Shimei Wu, Chaomin Sun
Summary: Through transcriptomics and proteomics analysis, MerF was found to play a key role in bacterial flagellum biogenesis and motility by directly binding to the promoter of fliS. Expression of merF and fliS could be simultaneously upregulated by different heavy metals, indicating the importance of MerF in both bacterial and archaeal domains.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Microbiology
Rikuan Zheng, Chaomin Sun
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Ruining Cai, Jing Zhang, Rui Liu, Chaomin Sun
Summary: This study obtained 20 high-quality DPANN archaeal genomes from deep-sea hydrothermal vent sediments, revealing their broad diversity and metabolic characteristics in this special environment. Despite the small genome size and some incomplete biological processes, DPANN archaea have alternate strategies to address deficiencies and the potential to assimilate nitrogen and sulfur compounds.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Editorial Material
Environmental Sciences
Ning Ma, Chaomin Sun
Summary: The study found that the addition of cysteine can enhance bacterial resistance to cadmium and promote energy production; biofilm formation plays a positive role in bacterial cadmium resistance; when facing cadmium stress, the expression of genes related to biofilm formation will be significantly upregulated.
ENVIRONMENTAL MICROBIOLOGY REPORTS
(2021)
Article
Ecology
Rikuan Zheng, Rui Liu, Yeqi Shan, Ruining Cai, Ge Liu, Chaomin Sun
Summary: This study successfully isolated a representative strain of Izemoplasma from a deep-sea methane seep, providing detailed insights into its physiological, genomic, and metabolic characteristics. The novel strain demonstrated strong DNA-degradation potentials and the ability to utilize extracellular DNA for growth. The proposed new species and genus Xianfuyuplasma coldseepsis based on the description of strain zrk13 contributes to a better understanding of the metabolic potential and ecological role of Izemoplasma bacteria in deep ocean biogeochemical cycling.
Article
Microbiology
Chenchen Guo, Rikuan Zheng, Ruining Cai, Chaomin Sun, Shimei Wu
Summary: The study identified a novel bacterial strain, Pseudomonas marinensis gcc21, isolated from deep-sea cold seep sediment, which exhibited high catalytic activity of cold-active lipases at 4 degrees C. The strain's genome contained two novel encoding genes for cold-active lipases, Lipase 1 and Lipase 2.