Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies

Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants

(2020) Elodie Persyn et al.   Nature Communications

Morphometric analysis of thoracic aorta in Slc39a13/Zip13-KO mice

(2019) Takuya Hirose et al.   CELL AND TISSUE RESEARCH

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

(2019) Mengzhen Liu et al.   NATURE GENETICS

Small vessel disease: mechanisms and clinical implications

(2019) Joanna M Wardlaw et al.   LANCET NEUROLOGY

PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations

(2019) Mihir A Kamat et al.   BIOINFORMATICS

Genome-wide association study of cerebral small vessel disease reveals established and novel loci

(2019) Jaeyoon Chung et al.   BRAIN

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

(2019) Takeshi Yoneshiro et al.   NATURE

Bayesian multivariate reanalysis of large genetic studies identifies many new associations

(2019) Michael C. Turchin et al.   PLoS Genetics

Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol

(2019) Marios K Georgakis et al.   BRAIN

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

(2018) Rainer Malik et al.   NATURE GENETICS

Multi-trait analysis of genome-wide association summary statistics using MTAG

(2018) Patrick Turley et al.   NATURE GENETICS

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

(2018) Rikesh M. Rajani et al.   Science Translational Medicine

Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes

(2018) George Hindy et al.   STROKE

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

(2018) Loic Yengo et al.   HUMAN MOLECULAR GENETICS

Genome-wide meta-analysis identifies 3 novel loci associated with stroke

(2018) Rainer Malik et al.   ANNALS OF NEUROLOGY

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Ulk4 deficiency leads to hypomyelination in mice

(2017) Min Liu et al.   GLIA

MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data

(2017) Olena O Yavorska et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility

(2017) Daniel J Wright et al.   NATURE GENETICS

COL4A2 is associated with lacunar ischemic stroke and deep ICH

(2017) Kristiina Rannikmäe et al.   NEUROLOGY

DGIdb 3.0: a redesign and expansion of the drug–gene interaction database

(2017) Kelsy C Cotto et al.   NUCLEIC ACIDS RESEARCH

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Vascular Risk Factor Profiles Differ Between Magnetic Resonance Imaging-Defined Subtypes of Younger-Onset Lacunar Stroke

(2017) Loes C.A. Rutten-Jacobs et al.   STROKE

Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies

(2016) Philip C Haycock et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections

(2016) Dong-chuan Guo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

PhenoScanner: a database of human genotype–phenotype associations

(2016) James R. Staley et al.   BIOINFORMATICS

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells

(2016) Lu Chen et al.   CELL

Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies

(2016) Ganesh Chauhan et al.   LANCET NEUROLOGY

Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study

(2016) Sara L Pulit et al.   LANCET NEUROLOGY

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

(2016) Thomas J Hoffmann et al.   NATURE GENETICS

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Disease variants alter transcription factor levels and methylation of their binding sites

(2016) Marc Jan Bonder et al.   NATURE GENETICS

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

Gene expression elucidates functional impact of polygenic risk for schizophrenia

(2016) Menachem Fromer et al.   NATURE NEUROSCIENCE

Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRICLINICAL PERSPECTIVE

(2015) Benjamin F.J. Verhaaren et al.   Circulation-Cardiovascular Genetics

Perturbations of the cerebrovascular matrisome: A convergent mechanism in small vessel disease of the brain?

(2015) Anne Joutel et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRICLINICAL PERSPECTIVE

(2015) Benjamin F.J. Verhaaren et al.   Circulation-Cardiovascular Genetics

Prevalence of CADASIL and Fabry Disease in a Cohort of MRI Defined Younger Onset Lacunar Stroke

(2015) Laura L. Kilarski et al.   PLoS One

Molecular pathogenesis of Spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins

(2014) B.-H. Bin et al.   EMBO Molecular Medicine

The Extracellular Matrix Protein Laminin  2 Regulates the Maturation and Function of the Blood-Brain Barrier

(2014) M. J. Menezes et al.   JOURNAL OF NEUROSCIENCE

Quality control and conduct of genome-wide association meta-analyses

(2014) Thomas W Winkler et al.   Nature Protocols

Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling

(2014) Nathalie Beaufort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126

(2014) K. J. Paavola et al.   Science Signaling

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity

(2014) Yao Yao et al.   Nature Communications

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

(2013) Joanna M Wardlaw et al.   LANCET NEUROLOGY

Including known covariates can reduce power to detect genetic effects in case-control studies

(2012) Matti Pirinen et al.   NATURE GENETICS

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

(2012) S Hong Lee et al.   NATURE GENETICS

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

(2012) Céline Bellenguez et al.   NATURE GENETICS

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

Genetic Heritability of Ischemic Stroke and the Contribution of Previously Reported Candidate Gene and Genomewide Associations

(2012) Steve Bevan et al.   STROKE

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

(2010) Leonardo Pantoni   LANCET NEUROLOGY

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Diagnosis of Lacunar Infarcts within 6 Hours of Onset by Clinical and CT Criteria Versus MRI

(2009) Venkatakrishna Rajajee et al.   JOURNAL OF NEUROIMAGING

Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease

(2009) Kenju Hara et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cohort Profile: The Cardiovascular Risk in Young Finns Study

(2008) O. T Raitakari et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY