Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective
出版年份 2016 全文链接
标题
Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective
作者
关键词
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出版物
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Volume 2017, Issue 12, Pages 1549-1560
出版商
Wiley
发表日期
2016-09-28
DOI
10.1002/ejic.201600986
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Metal-based drugs that break the rules
- (2016) Claire S. Allardyce et al. DALTON TRANSACTIONS
- Biodistribution of the novel anticancer drug sodium trans -[tetrachloridobis(1 H -indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action
- (2016) Anna K. Bytzek et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism
- (2016) Aleksandar Bijelic et al. JOURNAL OF MEDICINAL CHEMISTRY
- Linking the future of anticancer metal-complexes to the therapy of tumour metastases
- (2015) Alberta Bergamo et al. CHEMICAL SOCIETY REVIEWS
- Noble metals in medicine: Latest advances
- (2015) Serenella Medici et al. COORDINATION CHEMISTRY REVIEWS
- Albumin binding and ligand-exchange processes of the Ru(iii) anticancer agent NAMI-A and its bis-DMSO analogue determined by ENDOR spectroscopy
- (2015) Michael I. Webb et al. DALTON TRANSACTIONS
- Influence of the binding of reduced NAMI-A to human serum albumin on the pharmacokinetics and biological activity
- (2015) V. Novohradský et al. DALTON TRANSACTIONS
- Interaction of anticancer Ru(iii) complexes with single stranded and duplex DNA model systems
- (2015) Domenica Musumeci et al. DALTON TRANSACTIONS
- An iridium(iii)-based irreversible protein–protein interaction inhibitor of BRD4 as a potent anticancer agent
- (2015) Hai-Jing Zhong et al. Chemical Science
- Antagonizing STAT3 Dimerization with a Rhodium(III) Complex
- (2014) Dik-Lung Ma et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels
- (2014) Serena Pillozzi et al. DALTON TRANSACTIONS
- Ruthenium metalation of proteins: the X-ray structure of the complex formed between NAMI-A and hen egg white lysozyme
- (2014) Luigi Messori et al. DALTON TRANSACTIONS
- Preclinical combination therapy of the investigational drug NAMI-A+ with doxorubicin for mammary cancer
- (2014) Alberta Bergamo et al. INVESTIGATIONAL NEW DRUGS
- Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy
- (2014) Suzanne Leijen et al. INVESTIGATIONAL NEW DRUGS
- NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application
- (2014) Robert Trondl et al. Chemical Science
- Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity
- (2014) Zenita Adhireksan et al. Nature Communications
- Biotransformations of Anticancer Ruthenium(III) Complexes: An X-Ray Absorption Spectroscopic Study
- (2013) Aviva Levina et al. CHEMISTRY-A EUROPEAN JOURNAL
- Interaction of Anticancer Ruthenium Compounds with Proteins: High-Resolution X-ray Structures and Raman Microscopy Studies of the Adduct between Hen Egg White Lysozyme and AziRu
- (2013) Alessandro Vergara et al. INORGANIC CHEMISTRY
- Investigating the Ruthenium Metalation of Proteins: X-ray Structure and Raman Microspectroscopy of the Complex between RNase A and AziRu
- (2013) Alessandro Vergara et al. INORGANIC CHEMISTRY
- EPR as a probe of the intracellular speciation of ruthenium(iii) anticancer compounds
- (2013) Michael I. Webb et al. Metallomics
- Influence of an anti-metastatic ruthenium(iii) prodrug on extracellular protein–protein interactions: studies by bio-layer interferometry
- (2013) Aviva Levina et al. Inorganic Chemistry Frontiers
- Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies
- (2012) Orsolya Dömötör et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Transferrin–cisplatin specifically deliver cisplatin to HepG2 cells in vitro and enhance cisplatin cytotoxicity
- (2012) Lian-Zhong Luo et al. Journal of Proteomics
- Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-pyrimidine-4-carboxylic Acid
- (2012) Vanessa Pierroz et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Distinct cellular fates for KP1019 and NAMI-A determined by X-ray fluorescence imaging of single cells
- (2012) Jade B. Aitken et al. Metallomics
- The intracellular trafficking pathway of transferrin
- (2011) Kristine M. Mayle et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Control of ligand-exchange processes and the oxidation state of the antimetastatic Ru(iii) complex NAMI-A by interactions with human serum albumin
- (2011) Michael I. Webb et al. DALTON TRANSACTIONS
- Library of second-generation cycloruthenated compounds and evaluation of their biological properties as potential anticancer drugs: Passing the nanomolar barrier
- (2011) Ludivine Fetzer et al. DALTON TRANSACTIONS
- Metal-based antitumour drugs in the post-genomic era: what comes next?
- (2011) Gianni Sava et al. DALTON TRANSACTIONS
- Synthesis, structures, cellular uptake and apoptosis-inducing properties of highly cytotoxic ruthenium-Norharman complexes
- (2011) Caiping Tan et al. DALTON TRANSACTIONS
- Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs
- (2011) Alberta Bergamo et al. DALTON TRANSACTIONS
- Pharmacokinetic study of sodium trans[tetrachlorobis(1H-indazole)-ruthenate (III)]/-indazole hydrochloride (1:1.1) (FFC14A) in patients with solid tumors
- (2011) M.M. Henke et al. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
- Ru binding to RNA following treatment with the antimetastatic prodrug NAMI-A in Saccharomyces cerevisiae and in vitro
- (2011) Alethia A. Hostetter et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Impact of albumin on drug delivery — New applications on the horizon
- (2011) Bakheet Elsadek et al. JOURNAL OF CONTROLLED RELEASE
- Approaching tumour therapy beyond platinum drugs
- (2011) A. Bergamo et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Characterization of a Ruthenium(III)/NAMI-A Adduct with Bovine Serum Albumin that Exhibits a High Anti-Metastatic Activity
- (2010) Mimi Liu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Ruthenium-based chemotherapeutics: are they ready for prime time?
- (2010) Emmanuel S. Antonarakis et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- The X-ray Structure of the Adduct between NAMI-A and Carbonic Anhydrase Provides Insights into the Reactivity of this Metallodrug with Proteins
- (2010) Angela Casini et al. ChemMedChem
- The status of platinum anticancer drugs in the clinic and in clinical trials
- (2010) Nial J. Wheate et al. DALTON TRANSACTIONS
- Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339
- (2010) Petra Heffeter et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- A categorization of metal anticancer compounds based on their mode of action
- (2009) Teresa Gianferrara et al. DALTON TRANSACTIONS
- Serum-protein interactions with anticancer Ru(III) complexes KP1019 and KP418 characterized by EPR
- (2009) Naniye Cetinbas et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Recent developments in ruthenium anticancer drugs
- (2009) Aviva Levina et al. Metallomics
- KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients
- (2008) Christian G. Hartinger et al. CHEMISTRY & BIODIVERSITY
- Characterisation of Cisplatin Binding Sites in Human Serum Proteins Using Hyphenated Multidimensional Liquid Chromatography and ESI Tandem Mass Spectrometry
- (2008) Joanna Will et al. ChemMedChem
- Cellular Uptake, Cytotoxicity, and Metabolic Profiling of Human Cancer Cells Treated with Ruthenium(II) Polypyridyl Complexes [Ru(bpy)2(NN)]Cl2with NN=bpy, phen, dpq, dppz, and dppn
- (2008) Ulrich Schatzschneider et al. ChemMedChem
- The reduction of (ImH)[trans-RuIIICl4(dmso)(Im)] under physiological conditions: preferential reaction of the reduced complex with human serum albumin
- (2008) Malgorzata Brindell et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Ga3+ as a mechanistic probe in Fe3+ transport: characterization of Ga3+ interaction with FbpA
- (2008) Katherine D. Weaver et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles
- (2008) Felix Kratz JOURNAL OF CONTROLLED RELEASE
- Hydrolysis study of the bifunctional antitumour compound RAPTA-C, [Ru(η6-p-cymene)Cl2(pta)]
- (2008) Claudine Scolaro et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Metal-Ligand Exchange Kinetics in Platinum and Ruthenium Complexes
- (2008) By Jan Reedijk
- Catalytic organometallic anticancer complexes
- (2008) S. J. Dougan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antitumour metal compounds: more than theme and variations
- (2007) Michael A. Jakupec et al. DALTON TRANSACTIONS
- Influence of the anionic ligands on the anticancer activity of Ru(II)–dmso complexes: Kinetics of aquation and in vitro cytotoxicity of new dicarboxylate compounds in comparison with their chloride precursors
- (2007) Ioannis Bratsos et al. JOURNAL OF INORGANIC BIOCHEMISTRY
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