期刊
DALTON TRANSACTIONS
卷 43, 期 32, 页码 12150-12155出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4dt01356e
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资金
- Associazione Genitori contro le Leucemie e Tumori Infantili Noi per Voi
- Associazione Italiana per la Ricerca sul Cancro
- EU COST [CM1105]
We report here that the established anticancer ruthenium(m) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a non-cytotoxic antimetastatic agent. In addition, evidence is given for selective inhibition of KCa 3.1 channels. The implications of these findings are discussed.
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