Efficient Dimerization Disruption of Leishmania infantum Trypanothione Reductase by Triazole-phenyl-thiazoles

An Insight into the Current Perspective and Potential Drug Targets for Visceral Leishmania (VL)

(2020) Rani Mansuri et al.   CURRENT DRUG TARGETS

Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases

(2020) Theo Battista et al.   MOLECULES

Pseudoirreversible slow‐binding inhibition of trypanothione reductase by a protein–protein interaction disruptor

(2020) Héctor Lucio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism

(2020) Francesco Saccoliti et al.   ChemMedChem

Current and emerging medications for the treatment of leishmaniasis

(2019) Jaya Chakravarty et al.   EXPERT OPINION ON PHARMACOTHERAPY

Caver Web 1.0: identification of tunnels and channels in proteins and analysis of ligand transport

(2019) Jan Stourac et al.   NUCLEIC ACIDS RESEARCH

Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase

(2019) Alejandro Revuelto et al.   ACS Infectious Diseases

1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview

(2019) Khurshed Bozorov et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting a Large Active Site: Structure‐Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase

(2019) Raoul De Gasparo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Molecular insights into trypanothione reductase-inhibitor interaction: A structure-based review

(2018) Neha Tiwari et al.   ARCHIV DER PHARMAZIE

Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma

(2018) Raoul De Gasparo et al.   ChemMedChem

Molecular targets and pathways for the treatment of visceral leishmaniasis

(2018) Vineet Jain et al.   DRUG DISCOVERY TODAY

Synthesis and leishmanicidal activity of eugenol derivatives bearing 1,2,3-triazole functionalities

(2018) Róbson Ricardo Teixeira et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability

(2018) Marta Ruiz-Santaquiteria et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent Development of Visceral Leishmaniasis Treatments: Successes, Pitfalls, and Perspectives

(2018) Fabiana Alves et al.   CLINICAL MICROBIOLOGY REVIEWS

Potential Antileishmanial Activity of a Triazole-Based Hybrid Peptide against Leishmania major

(2018) Krishnendu Maji et al.   ChemistrySelect

Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides

(2017) Héctor de Lucio et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity #

(2017) Marta Ruiz-Santaquiteria et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Polyamine-trypanothione pathway: an update

(2017) Andrea Ilari et al.   Future Medicinal Chemistry

The Ecstasy and Agony of Assay Interference Compounds

(2017) Courtney Aldrich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

(2017) Mark C. Field et al.   NATURE REVIEWS MICROBIOLOGY

Unraveling the structure and exciton coupling for multichromophoric merocyanine dye molecules

(2017) Federico Koch et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Drug resistance and treatment failure in leishmaniasis: A 21st century challenge

(2017) Alicia Ponte-Sucre et al.   PLoS Neglected Tropical Diseases

Ruthenium-Catalyzed Azide Alkyne Cycloaddition Reaction: Scope, Mechanism, and Applications

(2016) Johan R. Johansson et al.   CHEMICAL REVIEWS

Thiol redox biology of trypanosomatids and potential targets for chemotherapy

(2016) Alejandro E. Leroux et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Status of vaccine research and development of vaccines for leishmaniasis

(2016) Portia M. Gillespie et al.   VACCINE

The FTMap family of web servers for determining and characterizing ligand-binding hot spots of proteins

(2015) Dima Kozakov et al.   Nature Protocols

Copper-catalysed azide–alkyne cycloadditions (CuAAC): an update

(2015) Estela Haldón et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Helix mimetics: Recent developments

(2015) Andrew J. Wilson   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Comparison of hydrocarbon-and lactam-bridged cyclic peptides as dimerization inhibitors of Leishmania infantum trypanothione reductase

(2015) Pedro A. Sánchez-Murcia et al.   RSC Advances

Binding to Large Enzyme Pockets: Small-Molecule Inhibitors of Trypanothione Reductase

(2014) Elke Persch et al.   ChemMedChem

1,2,3-Triazole in Heterocyclic Compounds, Endowed with Biological Activity, through 1,3-Dipolar Cycloadditions

(2014) Antonino Lauria et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Epidemiology of visceral leishmaniasis

(2014) Paul Ready   Clinical Epidemiology

Probing the Dimerization Interface ofLeishmania infantumTrypanothione Reductase with Site-Directed Mutagenesis and Short Peptides

(2013) Miguel A. Toro et al.   CHEMBIOCHEM

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

MM-ISMSA: An Ultrafast and Accurate Scoring Function for Protein–Protein Docking

(2012) Javier Klett et al.   Journal of Chemical Theory and Computation

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

(2011) Stephen Patterson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological significance of triazole scaffold

(2010) Rajeev Kharb et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel Pyrrolopyrimidine-Based α-Helix Mimetics: Cell-Permeable Inhibitors of Protein−Protein Interactions

(2010) Ji Hoon Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Molecular Basis of Antimony Treatment in Leishmaniasis†

(2009) Paola Baiocco et al.   JOURNAL OF MEDICINAL CHEMISTRY

Trypanothione Reductase from Leishmania infantum: Cloning, Expression, Purification, Crystallization and Preliminary X-Ray Data Analysis

(2009) Paola Baiocco et al.   PROTEIN AND PEPTIDE LETTERS

Synthesis and Biological Evaluation of a 5-6-5 Imidazole-Phenyl-Thiazole Based α-Helix Mimetic

(2008) Christopher G. Cummings et al.   ORGANIC LETTERS