Hydrophobic Pocket Occupation Design of Difluoro-Biphenyl-Diarylpyrimidines as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: from N-Alkylation to Methyl Hopping on the Pyrimidine Ring

Druggability modification strategies of the diarylpyrimidine‐type non‐nucleoside reverse transcriptase inhibitors

(2021) Li Ding et al.   MEDICINAL RESEARCH REVIEWS

Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy

(2020) Yuan Lei et al.   MOLECULES

Rilpivirine in HIV-1-positive women initiating pregnancy: to switch or not to switch?

(2020) Pierre Frange et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs

(2020) Ting-Ting Li et al.   MOLECULES

Privileged scaffold inspired design of novel oxime-biphenyl-DAPYs in treatment of HIV-1

(2020) Yang Yang et al.   BIOORGANIC CHEMISTRY

Radiosensitization of human pancreatic cancer by piperlongumine analogues

(2020) Hao Ma et al.   CHINESE CHEMICAL LETTERS

Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors

(2020) Xiaomei Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway

(2019) Hui Wang et al.   ACS Chemical Neuroscience

Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors

(2019) Sheng Han et al.   CHINESE CHEMICAL LETTERS

Conformational restriction design of thiophene-biphenyl-DAPY HIV-1 non-nucleoside reverse transcriptase inhibitors

(2019) Yali Sang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N and E138K Mutants and Pharmacokinetic Profiles

(2019) Sheng Han et al.   ACS Infectious Diseases

Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

(2019) Kaijun Jin et al.   Acta Pharmaceutica Sinica B

Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): Our past twenty years

(2019) Chunlin Zhuang et al.   Acta Pharmaceutica Sinica B

Ligand-Based Design of Nondimethylphenyl-Diarylpyrimidines with Improved Metabolic Stability, Safety, and Oral Pharmacokinetic Profiles

(2019) Yali Sang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1

(2018) KaiJun Jin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors

(2018) Shuang-Xi Gu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic

(2018) Vigneshwaran Namasivayam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemoselective Suzuki-Miyaura Cross-Coupling via Kinetic Transmetallation

(2016) James W. B. Fyfe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin

(2015) James M. Apgar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rapid Identification of Keap1–Nrf2 Small-Molecule Inhibitors through Structure-Based Virtual Screening and Hit-Based Substructure Search

(2014) Chunlin Zhuang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rotamers or Diastereomers? An Overlooked NMR Solution

(2012) Dennis X. Hu et al.   JOURNAL OF ORGANIC CHEMISTRY

HIV-1 NNRTIs: structural diversity, pharmacophore similarity, and impliations for drug design

(2011) Peng Zhan et al.   MEDICINAL RESEARCH REVIEWS

Rilpivirine: a novel non-nucleoside reverse transcriptase inhibitor

(2009) Lucy Garvey et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

(2008) Christophe Pannecouque et al.   Nature Protocols