Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease

Epithelial splicing regulatory protein 2–mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis

(2020) Jeongeun Hyun et al.   JOURNAL OF CLINICAL INVESTIGATION

Dysregulated activation of fetal liver programme in acute liver failure

(2019) Jeongeun Hyun et al.   GUT

Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets

(2019) Yoon Yang et al.   SEMINARS IN LIVER DISEASE

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis

(2019) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

(2019) Florian R. Greten et al.   IMMUNITY

Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer

(2019) Jennifer Munkley et al.   eLife

Gene Expression Predicts Histological Severity and Reveals Distinct Molecular Profiles of Nonalcoholic Fatty Liver Disease

(2019) Stephen A. Hoang et al.   Scientific Reports

IL-1 Family Cytokine Pathways Underlying NAFLD: Towards New Treatment Strategies

(2018) Andreea-Manuela Mirea et al.   TRENDS IN MOLECULAR MEDICINE

Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration

(2018) Sushant Bangru et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture

(2018) Weng Chuan Peng et al.   CELL

Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

(2018) Iván M. Moya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NUAK2 is a critical YAP target in liver cancer

(2018) Wei-Chien Yuan et al.   Nature Communications

Hepatocellular carcinoma in a mouse model fed a choline-deficient, L-amino acid-defined, high-fat diet

(2017) Ayae Ikawa-Yoshida et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b

(2016) Sita Kugel et al.   CELL

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

(2016) Xiaobo Wang et al.   Cell Metabolism

Pathogenesis of Nonalcoholic Steatohepatitis

(2016) Mariana Verdelho Machado et al.   GASTROENTEROLOGY

A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer

(2016) Amon Asgharpour et al.   JOURNAL OF HEPATOLOGY

Nonalcoholic fatty liver disease: A precursor of the metabolic syndrome

(2015) Amedeo Lonardo et al.   DIGESTIVE AND LIVER DISEASE

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

(2015) Toshiro Moroishi et al.   GENES & DEVELOPMENT

Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease

(2015) Mariana Verdelho Machado et al.   JOURNAL OF HEPATOLOGY

TCGASpliceSeq a compendium of alternative mRNA splicing in cancer

(2015) Michael Ryan et al.   NUCLEIC ACIDS RESEARCH

Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis inMob1a/1b-deficient mice

(2015) Miki Nishio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wanderer, an interactive viewer to explore DNA methylation and gene expression data in human cancer

(2015) Anna Díez-Villanueva et al.   Epigenetics & Chromatin

ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation

(2015) Amruta Bhate et al.   Nature Communications

YAP is a critical oncogene in human cholangiocarcinoma

(2015) Tiemin Pei et al.   Oncotarget

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease

(2013) Cynthia A. Moylan et al.   HEPATOLOGY

The Hippo Pathway Effectors TAZ/YAP Regulate Dicer Expression and MicroRNA Biogenesis through Let-7

(2013) Steven G. Chaulk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells

(2013) Chia-Lin Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-alcoholic fatty liver disease contributes to hepatocarcinogenesis in non-cirrhotic liver: A clinical and pathological study

(2013) Jacob Alexander et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Paracrine Hedgehog Signaling Drives Metabolic Changes in Hepatocellular Carcinoma

(2012) I. S. Chan et al.   CANCER RESEARCH

Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace

(2012) György Baffy et al.   JOURNAL OF HEPATOLOGY

Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease

(2011) Cynthia D. Guy et al.   HEPATOLOGY

Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer

(2011) George M. Philips et al.   PLoS One

YAP is a candidate oncogene for esophageal squamous cell carcinoma

(2010) Tomoki Muramatsu et al.   CARCINOGENESIS

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

(2010) S. Benhamouche et al.   GENES & DEVELOPMENT

Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease

(2009) Wing–Kin Syn et al.   GASTROENTEROLOGY