Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy
出版年份 2019 全文链接
标题
Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy
作者
关键词
-
出版物
CELL RESEARCH
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-04-26
DOI
10.1038/s41422-019-0162-7
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A distinct immunophenotype identifies a subset of NPM1 -mutated AML with TET2 or IDH1/2 mutations and improved outcome
- (2018) Emily F. Mason et al. AMERICAN JOURNAL OF HEMATOLOGY
- A novel controlled release formulation of the Pin1 inhibitor ATRA to improve liver cancer therapy by simultaneously blocking multiple cancer pathways
- (2018) Dayun Yang et al. JOURNAL OF CONTROLLED RELEASE
- Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib
- (2018) Lynn Quek et al. NATURE MEDICINE
- Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations
- (2018) Andrew M. Intlekofer et al. NATURE
- Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells
- (2018) Shingo Kozono et al. Nature Communications
- High-dose ascorbate and arsenic trioxide selectively kill acute myeloid leukemia and acute promyelocytic leukemia blasts in vitro
- (2017) Nélida I. Noguera et al. Oncotarget
- IDH mutations in cancer and progress toward development of targeted therapeutics
- (2016) L. Dang et al. ANNALS OF ONCOLOGY
- Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
- (2016) David B. Sykes et al. CELL
- Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer
- (2016) O. Clark et al. CLINICAL CANCER RESEARCH
- The role of glutathione reductase and related enzymes on cellular redox homoeostasis network
- (2016) Narciso Couto et al. FREE RADICAL BIOLOGY AND MEDICINE
- Pin1 inhibitor Juglone prevents diabetic vascular dysfunction
- (2016) Sarah Costantino et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia
- (2016) Héléna Boutzen et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies
- (2016) Sonika Patial et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- One-carbon metabolism and epigenetics: understanding the specificity
- (2015) Samantha J. Mentch et al. Annals of the New York Academy of Sciences
- C/EBPα in normal and malignant myelopoiesis
- (2015) Alan D. Friedman INTERNATIONAL JOURNAL OF HEMATOLOGY
- Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer
- (2015) Shuo Wei et al. NATURE MEDICINE
- Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia
- (2015) Steven M Chan et al. NATURE MEDICINE
- Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature
- (2015) Pierre Cauchy et al. Cell Reports
- Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance
- (2014) Lev M. Kats et al. Cell Stem Cell
- Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis
- (2013) Vera Mugoni et al. CELL
- Lessons from the Cancer Genome
- (2013) Levi A. Garraway et al. CELL
- Structure of human Sp140 PHD finger: an atypical fold interacting with Pin1
- (2013) Chiara Zucchelli et al. FEBS Journal
- What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
- (2013) J.-A. Losman et al. GENES & DEVELOPMENT
- Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition
- (2013) C. Chen et al. GENES & DEVELOPMENT
- Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation
- (2013) F. Wang et al. SCIENCE
- Characterization and Analysis of the Composition and Dynamics of the Mammalian Riboproteome
- (2013) Markus Reschke et al. Cell Reports
- Cytotoxic effect of arsenic trioxide on acute promyelocytic leukemia cells through suppression of NFkβ-dependent induction of hTERT due to down-regulation of Pin1 transcription
- (2012) Seyed H. Ghaffari et al. Hematology
- Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
- (2012) Tino Schenk et al. NATURE MEDICINE
- The prolyl isomerase Pin1 acts as a novel molecular switch for TNF- -induced priming of the NADPH oxidase in human neutrophils
- (2010) T. Boussetta et al. BLOOD
- PML-RARα/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia
- (2010) Joost H.A. Martens et al. CANCER CELL
- PML Nuclear Body Component Sp140 Is a Novel Autoantigen in Primary Biliary Cirrhosis
- (2009) Alessandro Granito et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Inhibition of the Peptidyl-Prolyl-Isomerase Pin1 Enhances the Responses of Acute Myeloid Leukemia Cells to Retinoic Acid via Stabilization of RAR and PML-RAR
- (2009) M. Gianni' et al. CANCER RESEARCH
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