PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors

(2021) Kelly C. Higa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer as a disease of old age: changing mutational and microenvironmental landscapes

(2020) Ezio Laconi et al.   BRITISH JOURNAL OF CANCER

Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency

(2020) Raymond Liang et al.   Cell Stem Cell

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition

(2020) Ashwini Hinge et al.   Cell Stem Cell

Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs

(2020) Tomoya Muto et al.   NATURE IMMUNOLOGY

MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia

(2020) Alfredo Rodríguez et al.   Cell Stem Cell

N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells

(2019) Meng Zhao et al.   Cell Reports

Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis

(2019) Giovanny Hernandez et al.   HAEMATOLOGICA

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies

(2019) Molly A. Smith et al.   NATURE CELL BIOLOGY

TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration

(2019) Masayuki Yamashita et al.   Cell Stem Cell

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia

(2019) Mark D. McKenzie et al.   Cell Stem Cell

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

CD34 and EPCR coordinately enrich functional murine hematopoietic stem cells under normal and inflammatory conditions

(2019) Jennifer L. Rabe et al.   EXPERIMENTAL HEMATOLOGY

Mouse and human HSPC immobilization in liquid culture by CD43- or CD44-antibody coating

(2018) Dirk Loeffler et al.   BLOOD

NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling

(2018) Pablo R. Freire et al.   BLOOD

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding

(2018) Hiroyuki Hosokawa et al.   IMMUNITY

IL1RAP potentiates multiple oncogenic signaling pathways in AML

(2018) Kelly Mitchell et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response

(2018) Richard H Chapple et al.   eLife

Identification of immune-activated hematopoietic stem cells

(2018) Nir Bujanover et al.   LEUKEMIA

Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes

(2018) Brett M. Stevens et al.   Nature Communications

Inflammatory signals directly instruct PU.1 in HSCs via TNF

(2018) Martin Etzrodt et al.   BLOOD

Senescence is a Spi1-induced anti-proliferative mechanism in primary hematopoietic cells

(2017) Laure Delestré et al.   HAEMATOLOGICA

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

C/EBPα deregulation as a paradigm for leukemogenesis

(2017) J A Pulikkan et al.   LEUKEMIA

Coordination of Myeloid Differentiation with Reduced Cell Cycle Progression by PU.1 Induction of MicroRNAs Targeting Cell Cycle Regulators and Lipid Anabolism

(2017) Lauren A. Solomon et al.   MOLECULAR AND CELLULAR BIOLOGY

A BaSiC tool for background and shading correction of optical microscopy images

(2017) Tingying Peng et al.   Nature Communications

Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia

(2017) Alyssa Carey et al.   Cell Reports

Senescence is a Spi1-induced anti-proliferative mechanism in primary hematopoietic cells

(2017) Laure Delestré et al.   HAEMATOLOGICA

IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

(2016) H. Agerstam et al.   BLOOD

Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor-treated CML stem cells

(2016) B. Zhang et al.   BLOOD

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause

(2016) Roberta Scognamiglio et al.   CELL

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia

(2016) Noemi A. Zambetti et al.   Cell Stem Cell

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs

(2016) Robert A.J. Signer et al.   GENES & DEVELOPMENT

Hyperinflammation in patients with chronic granulomatous disease leads to impairment of hematopoietic stem cell functions

(2016) Maren Weisser et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios

(2016) Philipp S. Hoppe et al.   NATURE

Software tools for single-cell tracking and quantification of cellular and molecular properties

(2016) Oliver Hilsenbeck et al.   NATURE BIOTECHNOLOGY

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

(2016) Eric M. Pietras et al.   NATURE CELL BIOLOGY

PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity

(2016) Nélida Inés Noguera et al.   Oncotarget

Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis

(2016) Petter Säwén et al.   Cell Reports

Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation

(2016) Katie A. Matatall et al.   Cell Reports

Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines

(2016) Shaina N. Porter et al.   Stem Cell Reports

InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams

(2015) Henry Heberle et al.   BMC BIOINFORMATICS

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors

(2015) Simon Haas et al.   Cell Stem Cell

Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors

(2015) Curtis J. Henry et al.   JOURNAL OF CLINICAL INVESTIGATION

Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

(2015) I Gañán-Gómez et al.   LEUKEMIA

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia

(2015) Britta Will et al.   NATURE MEDICINE

ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap

(2015) Tauno Metsalu et al.   NUCLEIC ACIDS RESEARCH

To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes

(2015) Melody M.H. Li et al.   TRENDS IN CELL BIOLOGY

Hematopoietic stem cells, infection, and the niche

(2014) Áine M. Prendergast et al.   Annals of the New York Academy of Sciences

Posttranscriptional regulation of c-Myc expression in adult murine HSCs during homeostasis and interferon- -induced stress response

(2014) A. Ehninger et al.   BLOOD

Omacetaxine: A Protein Translation Inhibitor for Treatment of Chronic Myelogenous Leukemia

(2014) V. Gandhi et al.   CLINICAL CANCER RESEARCH

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons

(2014) Eric M. Pietras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NF-κB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia

(2014) D Gerloff et al.   LEUKEMIA

G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling

(2014) L G Schuettpelz et al.   LEUKEMIA

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

(2014) Joseph T. Rodgers et al.   NATURE

Haematopoietic stem cells require a highly regulated protein synthesis rate

(2014) Robert A. J. Signer et al.   NATURE

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Chronic variable stress activates hematopoietic stem cells

(2014) Timo Heidt et al.   NATURE MEDICINE

Selective killing of candidate AML stem cells by antibody targeting of IL1RAP

(2013) M. Askmyr et al.   BLOOD

Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome

(2013) Garrett W. Rhyasen et al.   CANCER CELL

PU.1 promotes cell cycle exit in the murine myeloid lineage associated with downregulation of E2F1

(2013) Rachel Ziliotto et al.   EXPERIMENTAL HEMATOLOGY

Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells

(2013) Philipp B. Staber et al.   MOLECULAR CELL

Positive Feedback Between PU.1 and the Cell Cycle Controls Myeloid Differentiation

(2013) H. Y. Kueh et al.   SCIENCE

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS

(2012) L. Barreyro et al.   BLOOD

Down-regulation of hematopoiesis master regulator PU.1 via aberrant methylation in chronic myeloid leukemia

(2012) Hui Yang et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling

(2011) K. Y. King et al.   BLOOD

p57 Is Required for Quiescence and Maintenance of Adult Hematopoietic Stem Cells

(2011) Akinobu Matsumoto et al.   Cell Stem Cell

Cell cycle regulation in hematopoietic stem cells

(2011) Eric M. Pietras et al.   JOURNAL OF CELL BIOLOGY

Inflammation Triggers Emergency Granulopoiesis through a Density-Dependent Feedback Mechanism

(2011) Derek W. Cain et al.   PLoS One

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Risks of myeloid malignancies in patients with autoimmune conditions

(2009) L A Anderson et al.   BRITISH JOURNAL OF CANCER

IL-1R Type I-Dependent Hemopoietic Stem Cell Proliferation Is Necessary for Inflammatory Granulopoiesis and Reactive Neutrophilia

(2009) Yoshihiro Ueda et al.   JOURNAL OF IMMUNOLOGY

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity

(2008) Elisa Laurenti et al.   Cell Stem Cell

Dynamic regulation ofc-Myc proto-oncogene expression during lymphocyte development revealed by aGFP-c-Myc knock-in mouse

(2008) Ching-Yu Huang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

(2008) Adlen Foudi et al.   NATURE BIOTECHNOLOGY

Activation of CCAAT/Enhancer-Binding Protein α or PU.1 in Hematopoietic Stem Cells Leads to Their Reduced Self-Renewal and Proliferation

(2008) Yumi Fukuchi et al.   STEM CELLS