Article
Clinical Neurology
Tingting Xu, Qiumeng Gu, Qing Zhao, Pei Wang, Qiang Liu, Qing Fan, Jue Chen, Zhen Wang
Summary: The study identified alterations in striatal functional connectivity in patients with OCD compared to healthy controls, suggesting a breakdown in cognitive circuits involved in inhibitory control. The relationship between trait impulsivity and frontal-striatal connectivity may have negative implications in OCD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Behavioral Sciences
Andrew Westbrook, Michael J. Frank, Roshan Cools
Summary: Dopamine plays a positive role in cognitive control, affecting both cognitive control capacity and cognitive motivation. Striatal dopamine may enhance control by increasing sensitivity to the costs and benefits of cognitive effort, shaping competition between controlled and prepotent actions. Differing cost-benefit tradeoffs mediated by dopamine signaling in distinct cortico-striatal subregions may reconcile conflicting findings on the impact of dopamine on cognitive control.
TRENDS IN COGNITIVE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Suzuka Narukawa, Momoka Nishimura, Izumi Kuze, Ibuki Ohno, Masaki Fukunaga, Kohta I. Kobayasi, Shota A. Murai
Summary: This study investigated the neural correlates of rotating fidget spinners using functional magnetic resonance imaging. The results showed that several brain regions associated with motor control were activated during the rotation of spinners. Furthermore, easier-to-rotate spinners elicited stronger neural activity. The analysis also revealed increased functional connectivity between the cortex and striatum during spinner rotation.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Ana K. Pimentel-Farfan, Ana S. Baez-Cordero, Teresa M. Pena-Rangel, Pavel E. Rueda-Orozco
Summary: This study investigated the interactions between the cortex and striatum in bilaterally coordinated movements in rats. It found that bilateral actions are initiated by the motor cortex regions, with the striatum influencing movement duration and kinematic parameters.
Article
Biochemical Research Methods
Michelle J. Redinbaugh, Mohsen Afrasiabi, Jessica M. Phillips, Niranjan A. Kambi, Sounak Mohanta, Aeyal Raz, Yuri B. Saalmann
Summary: Anesthetic manipulations provide causal evidence for neural correlates of consciousness, although drug effects complicate interpretation. Thalamic deep brain stimulation (DBS) can modulate consciousness, depending on the stimulation target. Stimulation of the central lateral thalamus (CL) induces abnormal staring behavior with low-frequency oscillations and alters communication in cortico-striato-thalamic (CST) circuits, similar to absence epilepsy.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Neurosciences
Patrick A. F. Laing, Trevor Steward, Christopher G. Davey, Kim L. Felmingham, Miguel Angel Fullana, Bram Vervliet, Matthew D. Greaves, Bradford Moffat, Rebecca K. Glarin, Ben J. Harrison
Summary: This study investigates the neural basis of safety learning using advanced fMRI technology, and finds that safety learning is mediated through a cortico-striatal circuitry separate from broader cortical regions involved in processing standard safety signals.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Dennis Vollweiter, Jasmeet Kaur Shergill, Alexandra Hilse, Gaga Kochlamazashvili, Stefan Paul Koch, Susanne Mueller, Philipp Boehm- Sturm, Volker Haucke, Tanja Maritzen
Summary: The cortico-striatal-thalamocortical loop is crucial for the expression of motor routines and habits. Mutations in the intersectin proteins have been linked to neuropsychiatric diseases such as ASD and OCD. Deletion of the intersectin proteins leads to severe ASD/OCD-like behavioral alterations and defective cortico-striatal neurotransmission. The findings provide insights into the physiological role of intersectin in countering ASD/OCD and the molecular pathomechanism behind these neuropsychiatric symptoms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Antonio Fernandez, Nina M. Hanning, Marisa Carrasco
Summary: This study investigates the causal role of rFEF+ and V1/V2 in endogenous attention using transcranial magnetic stimulation (TMS). The results show that early visual areas do not modulate endogenous attention, while rFEF+ plays a critical role in this process.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Gustavo Sudre, Derek E. Gildea, Gauri G. Shastri, Wendy Sharp, Benjamin Jung, Qing Xu, Pavan K. Auluck, Laura Elnitski, Andreas D. Baxevanis, Stefano Marenco, Philip Shaw
Summary: This study investigated the transcriptome of the caudate nucleus and anterior cingulate cortex in individuals with and without ADHD. Significant differential expression of genes was found, particularly in neurotransmitter gene pathways. These findings provide evidence for cortico-striatal neurotransmitter anomalies in the pathogenesis of ADHD, consistent with current models of the disorder.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
A. Bertero, L. Verrillo, A. J. Apicella
Summary: This study reveals the existence of a long-range class of pyramidal neurons (CS-L4 neurons) in layer 4 of the mouse auditory cortex that receive direct thalamic inputs and establish connections with local parvalbumin neurons, contributing to a feedforward inhibitory circuit in the posterior striatum.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Francesca Mottarlini, Marco Fumagalli, Fernando Castillo-Diaz, Stefano Piazza, Giorgia Targa, Enrico Sangiovanni, Barbara Pacchetti, Mikael H. Sodergren, Mario Dell'Agli, Fabio Fumagalli, Lucia Caffino
Summary: CBD can be found in the rat brain, specifically in the medial prefrontal cortex, and has a dose-dependent modulation of BDNF, suggesting its potential therapeutic value in psychiatric and neurodegenerative disorders.
Review
Biochemistry & Molecular Biology
Patrick T. Piantadosi, Lindsay R. Halladay, Anna K. Radke, Andrew Holmes
Summary: The risk of aversive consequences from reward-seeking behavior can significantly impact future actions, with individuals adapting differently to negative and positive punishment risks. Those with substance use disorders or behavioral addictions may struggle to reduce addictive behaviors despite aversive consequences. Dopamine signaling and interconnected ventral striatal, cortical, and amygdala regions play critical roles in punishment learning and risky reward seeking behavior.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Sonia Turrini, Francesca Fiori, Emilio Chiappini, Emiliano Santarnecchi, Vincenzo Romei, Alessio Avenanti
Summary: Cortico-cortical paired associative stimulation (ccPAS) is an effective method for inducing associative plasticity in the brain. This study investigated the physiological changes during ccPAS administration and found both facilitatory and inhibitory effects. Monitoring motor-evoked potentials (MEPs) online could provide insights into the effectiveness of the protocol.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Laurie Hamel, Bilgehan Cavdaroglu, Dylan Yeates, David Nguyen, Sadia Riaz, Dylan Patterson, Nisma Khan, Nardin Kirolos, Katherine Roper, Quynh An Ha, Rutsuko Ito
Summary: The study aimed to investigate the role of the mPFC and NAc in cue-elicited adaptive responding, finding that the mPFC plays a crucial role in regulating nonreinforced cue responding.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Psychiatry
Karianne Sretavan Wong, Tina Chou, Amy T. Peters, Kristen K. Ellard, Andrew A. Nierenberg, Darin D. Dougherty, Thilo Deckersbach
Summary: This study investigated the relationship between subjective and objective measures of apathy, disinhibition, and executive dysfunction and the activation of the anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), and orbitofrontal cortex (OFC) during a modified version of the Multi-Source Interference Task (MSIT). The results showed that both individuals with Bipolar Disorder (BD) and healthy controls (HC) exhibited greater activation in the ACC, DLPFC, and OFC during MSIT interference conditions. Moreover, there was a significant negative correlation between OFC activation and disinhibition scores.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Sergi Ferre, Francisco Ciruela, Carmen W. Dessauer, Javier Gonzalez-Maeso, Terence E. Hebert, Ralf Jockers, Diomedes E. Logothetis, Leonardo Pardo
Summary: The study proposes the concept of GPCR-effect assemblies (GEMMAs), which are pre-assembled before receptor activation and allow more efficient interactions between specific signaling components. This offers an alternative model to the conventional collision coupling model and explains the differential properties of GPCRs in different cellular environments.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Matilde S. Rodrigues, Samira G. Ferreira, Cesar Quiroz, Christopher J. Earley, Diego Garcia-Borreguero, Rodrigo A. Cunha, Francisco Ciruela, Attila Kofalvi, Sergi Ferre
Summary: Brain iron deficiency (BID) is a primary mechanism in restless legs syndrome (RLS), and BID in rodents has been used as an animal model for RLS. Previous studies have shown that BID leads to increased sensitivity of cortical pyramidal cells to glutamate release, which is correlated with the motor hyperexcitability observed in RLS patients. It has also been found that BID in rodents causes changes in the adenosinergic system, specifically a downregulation of inhibitory adenosine A(1) receptors (A(1)Rs) and an upregulation of excitatory adenosine A(2A) receptors (A(2A)Rs). This study aimed to investigate the relationship between A(1)Rs and A(2A)Rs in cortico-striatal and thalamo-striatal glutamatergic terminals of control and BID rats using a FACS-based synaptometric analysis. The results showed a selective decrease in the A(1)R/A(2A)R ratio in VGLUT1 positive-striatal terminals in BID rats.
Article
Cell Biology
Aaro Salminen, Stefan Clemens, Diego Garcia-Borreguero, Imad Ghorayeb, Yuqing Li, Mauro Manconi, William Ondo, David Rye, Jerome M. Siegel, Alessandro Silvani, John W. Winkelman, Richard P. Allen, Sergi Ferre
Summary: Our understanding of restless legs syndrome (RLS) is still incomplete, mainly due to the lack of objective diagnostic biomarkers. In this article, a group of preclinical and clinical scientists establishes new guidelines for constructing valid rodent models of RLS, considering the risk factors, triggering factors, and pathophysiological mechanisms that influence RLS expressivity. This research aims to provide translational implications for better diagnosing and treating RLS.
DISEASE MODELS & MECHANISMS
(2022)
Article
Pharmacology & Pharmacy
Paulo A. De Oliveira, Estefania Moreno, Nil Casajuana-Martin, Veronica Casado-Anguera, Ning-Sheng Cai, Gisela Andrea Camacho-Hernandez, Hu Zhu, Alessandro Bonifazi, Matthew D. Hall, David Weinshenker, Amy Hauck Newman, Diomedes E. Logothetis, Vicent Casado, Leigh D. Plant, Leonardo Pardo, Sergi Ferre
Summary: Recent studies suggest that the heteromers of mu-opioid receptors (MORs) and galanin Gal(1) receptors (Gal(1)Rs) in the mesencephalon play a role in mediating the dopaminergic effects of opioids. This study provides evidence for a predominant homodimeric structure of MOR and Gal(1)R when expressed individually and for their preference to form functional heterotetramers when co-expressed. The results show that this heteromerization leads to a change in G-protein coupling, providing a framework for Gs-Gi antagonist interaction.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Neurosciences
Christopher J. Earley, Byron C. Jones, Sergi Ferre
Summary: This article discusses the two main pathological elements of Restless Legs Syndrome (RLS): brain iron deficiency (BID) and altered dopaminergic system. Through research on diet-induced BID rodent models, it is possible to gain a better understanding of the effects of brain iron deficiency on the dopaminergic pathway and other potential pathways.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Estefania Moreno, Nil Casajuana-Martin, Michael Coyle, Baruc Campos Campos, Ewa Galaj, Claudia Llinas del Torrent, Arta Seyedian, William Rea, Ning-Sheng Cai, Alessandro Bonifazi, Benjamin Floran, Zheng-Xiong Xi, Xavier Guitart, Vicent Casado, Amy H. Newman, Christopher Bishop, Leonardo Pardo, Sergi Ferre
Summary: This study provides evidence that heteromerization of G protein-coupled receptors (GPCRs), specifically dopamine D1 and D3 receptors, can influence the pharmacological properties of selective ligands. In vivo experiments support the involvement of D1R-D3R heteromers in the development of L-DOPA-induced dyskinesia in Parkinson's disease, suggesting the potential of targeting GPCR heteromers for drug development.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Sergi Ferre, Annabelle M. Belcher, Jordi Bonaventura, Cesar Quiroz, Marta Sanchez-Soto, Veronica Casado-Anguera, Ning-Sheng Cai, Estefania Moreno, Comfort A. Boateng, Thomas M. Keck, Benjamin Floran, Christopher J. Earley, Francisco Ciruela, Vicent Casado, Marcelo Rubinstein, Nora D. Volkow
Summary: The dopamine D4 receptor and its polymorphic variants play important roles in dopaminergic and noradrenergic modulation, and are associated with various disorders such as impulse-control disorders. Research on the D4 receptor helps to understand the regulatory mechanisms of impulsivity as a personality trait, and provides valuable therapeutic targets for diseases such as ADHD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Laura Sarasola, Claudia Llinas del Torrent, Andrea Perez-Arevalo, Josep Argerich, Nil Casajuana-Martin, Andy Chevigne, Victor Fernandez-Duenas, Sergi Ferre, Leonardo Pardo, Francisco Ciruela
Summary: This study reveals that the ADORA1 mutation associated with Parkinson's disease affects the heteromerization of adenosine receptors, contributing to the development of neurodegenerative diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Sergi Ferre, Laura I. Sarasola, Cesar Quiroz, Francisco Ciruela
Summary: Adenosine plays a significant role in modulating striatal neurotransmission, which is mediated by A1 and A2A receptors. The modulation involves different components of the striatal microcircuit and the formation of heteromers. These heteromers have unique properties and provide fine-tune modulation of striatal glutamate release. Targeting these adenosine receptor heteromers may be important for drug development in neuropsychiatric disorders.
Article
Pharmacology & Pharmacy
Sergi Ferre, Attila Kofalvi, Francisco Ciruela, Zuzana Justinova, Marco Pistis
Summary: The rewarding effects of cannabinoids are believed to be mediated by CB1 receptors, but recent results suggest that dopaminergic neurons also play a role in the aversive effects of cannabinoids. Additionally, A2AR antagonists have been shown to counteract the self-administration of THC, suggesting a potential treatment for cannabinoid use disorder. Recent experiments in rodents and imaging studies in humans support the involvement of cortical astrocytic CB1 receptors and A2AR receptor heteromers in this process.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Yaoheng Yang, Jinyun Yuan, Rachael L. Field, Dezhuang Ye, Zhongtao Hu, Kevin Xu, Lu Xu, Yan Gong, Yimei Yue, Alexxai V. Kravitz, Michael R. Bruchas, Jianmin Cui, Jonathan R. Brestoff, Hong Chen
Summary: By using ultrasound to activate specific neurons in the hypothalamus, researchers have successfully induced a torpor-like state in rodents, characterized by hypothermia and reduced metabolic rate. This noninvasive technique involves closed-loop feedback control of ultrasound stimulation and automated detection of body temperature. The study identifies TRPM2 as an ultrasound-sensitive ion channel in the hypothalamus preoptic area, and demonstrates the feasibility of ultrasound-induced hypothermia and hypometabolism in non-torpid animals.
Article
Clinical Neurology
Sergi Ferre, John Winkelman, Diego Garcia-Borreguero, Annabelle Belcher, Joy Chang, Christopher Earley
Summary: Restlessness is a common symptom in restless legs syndrome, neuroleptic-induced akathisia, and opioid withdrawal. These conditions may share the same underlying neurobiological basis involving specific striatal neurons.
Article
Multidisciplinary Sciences
Donghua Hu, Min Tan, Dongliang Lu, Brian Kleiboeker, Xuejing Liu, Hongsuk Park, Alexxai V. Kravitz, Kooresh I. Shoghi, Yu-Hua Tseng, Babak Razani, Akihiro Ikeda, Irfan J. Lodhi
Summary: Mitochondrial morphology, regulated by fission and fusion, plays a crucial role in the thermogenic capacity of brown adipocytes. TMEM135 has been identified as a critical mediator in the regulation of mitochondrial fission and thermogenesis, providing a potential target for therapeutic activation of brown adipose tissue.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Neurosciences
Stephanie Foster, Jung Hoon Shin, Ewa Galaj, Alyssa Petko, Falyn Thomas, Carlos Paladini, Sergi Ferre, Veronica Alvarez, David Weinshenker
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
William Norbey Sanchez Luna, Jose A. Pochapski, Nicolas Cordeiro, Roberto Andreatini, Rainer K. Schwarting, Donita L. Robinson, Sergi Ferre, Claudio da Cunha
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.