Endosomal escape cell-penetrating peptides significantly enhance pharmacological effectiveness and CNS activity of systemically administered antisense oligonucleotides
出版年份 2021 全文链接
标题
Endosomal escape cell-penetrating peptides significantly enhance pharmacological effectiveness and CNS activity of systemically administered antisense oligonucleotides
作者
关键词
Cell-penetrating peptides, Endosomal escape, Blood-brain barrier, Antisense oligonucleotides, Antisense Therapy
出版物
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 599, Issue -, Pages 120398
出版商
Elsevier BV
发表日期
2021-02-26
DOI
10.1016/j.ijpharm.2021.120398
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The 10th Oligonucleotide Therapy Approved: Golodirsen for Duchenne Muscular Dystrophy
- (2020) Annemieke Aartsma-Rus et al. Nucleic Acid Therapeutics
- The powerful world of antisense oligonucleotides: From bench to bedside
- (2020) Anaïs M. Quemener et al. Wiley Interdisciplinary Reviews-RNA
- Cell penetrating peptides: as a promising theranostics strategy to circumvent the blood-brain barrier for CNS diseases
- (2020) Behrang Shiri Varnamkhasti et al. Current Drug Delivery
- Cell-Penetrating Peptides in Diagnosis and Treatment of Human Diseases: From Preclinical Research to Clinical Application
- (2020) Jing Xie et al. Frontiers in Pharmacology
- Cell-Penetrating Peptides Escape the Endosome by Inducing Vesicle Budding and Collapse
- (2020) Ashweta Sahni et al. ACS Chemical Biology
- Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys
- (2020) Diana Alarcón-Arís et al. EBioMedicine
- Thiol-Cyanobenzothiazole Ligation for the Efficient Preparation of Peptide-PNA Conjugates
- (2019) Nitin Patil et al. BIOCONJUGATE CHEMISTRY
- Scavenger Receptor Class A1 Mediates Uptake of Morpholino Antisense Oligonucleotide into Dystrophic Skeletal Muscle
- (2019) Shouta Miyatake et al. Molecular Therapy-Nucleic Acids
- Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease
- (2019) Michael F. Egan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Novel pH Selective, Highly Lytic Peptides Based on a Chimeric Influenza Hemagglutinin Peptide/Cell Penetrating Peptide Motif
- (2019) Bethany Algayer et al. MOLECULES
- Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle
- (2019) Thazha P Prakash et al. NUCLEIC ACIDS RESEARCH
- Lipid Conjugates Enhance Endosomal Release of Antisense Oligonucleotides Into Cells
- (2019) Shiyu Wang et al. Nucleic Acid Therapeutics
- Polyhistidine facilitates direct membrane translocation of cell-penetrating peptides into cells
- (2019) Han-Jung Lee et al. Scientific Reports
- Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease
- (2019) Jinkuk Kim et al. NEW ENGLAND JOURNAL OF MEDICINE
- Therapeutic Antisense Targeting of Huntingtin
- (2019) Anne V. Smith et al. DNA AND CELL BIOLOGY
- Nusinersen for older patients with spinal muscular atrophy: A real‐world clinical setting experience
- (2019) Aravindhan Veerapandiyan et al. MUSCLE & NERVE
- The First Approved Gene Therapy Product for Cancer Ad-p53 (Gendicine): 12 Years in the Clinic
- (2018) Wei-Wei Zhang et al. HUMAN GENE THERAPY
- Endosomal Escape of Antisense Oligonucleotides Internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 During Endosomal Maturation
- (2018) Colton M. Miller et al. Nucleic Acid Therapeutics
- Membrane Destabilization Induced by Lipid Species Increases Activity of Phosphorothioate-Antisense Oligonucleotides
- (2018) Shiyu Wang et al. Molecular Therapy-Nucleic Acids
- A novel amphipathic cell-penetrating peptide based on the N-terminal glycosaminoglycan binding region of human apolipoprotein E
- (2018) Takashi Ohgita et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Amphiphilic lipopeptide significantly enhances uptake of charge-neutral splice switching morpholino oligonucleotide in spinal muscular atrophy patient-derived fibroblasts
- (2017) Behnoosh Tajik-Ahmadabad et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Routes for Drug Translocation Across the Blood-Brain Barrier: Exploiting Peptides as Delivery Vectors
- (2017) Mie Kristensen et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Therapies targeting DNA and RNA in Huntington's disease
- (2017) Edward J Wild et al. LANCET NEUROLOGY
- A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism
- (2017) Yu Meng et al. MOLECULAR THERAPY
- Combination of valproic acid and morpholino splice-switching oligonucleotide produces improved outcomes in spinal muscular atrophy patient-derived fibroblasts
- (2017) Anna Farrelly-Rosch et al. NEUROCHEMISTRY INTERNATIONAL
- Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs
- (2017) Xiulong Shen et al. NUCLEIC ACIDS RESEARCH
- Transcellular vesicular transport in epithelial and endothelial cells: Challenges and opportunities
- (2017) Karen Y. Y. Fung et al. TRAFFIC
- FDA Approval of Nusinersen for Spinal Muscular Atrophy Makes 2016 the Year of Splice Modulating Oligonucleotides
- (2017) Annemieke Aartsma-Rus Nucleic Acid Therapeutics
- FDA Approves Eteplirsen for Duchenne Muscular Dystrophy: The Next Chapter in the Eteplirsen Saga
- (2017) Annemieke Aartsma-Rus et al. Nucleic Acid Therapeutics
- Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy
- (2017) Fazel Shabanpoor et al. Nucleic Acid Therapeutics
- An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry
- (2016) Scott H. Medina et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Blood–brain barrier shuttle peptides: an emerging paradigm for brain delivery
- (2016) Benjamí Oller-Salvia et al. CHEMICAL SOCIETY REVIEWS
- The delivery of therapeutic oligonucleotides
- (2016) Rudolph L. Juliano NUCLEIC ACIDS RESEARCH
- Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy
- (2016) Suzan M. Hammond et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier
- (2016) Roberto Villaseñor et al. Scientific Reports
- Delivery of therapeutic oligonucleotides with cell penetrating peptides
- (2015) Prisca Boisguérin et al. ADVANCED DRUG DELIVERY REVIEWS
- Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides
- (2015) Kariem Ezzat et al. NANO LETTERS
- An apolipoprotein E modified liposomal nanoparticle: Ligand dependent efficiency as a siRNA delivery carrier for mouse-derived brain endothelial cells
- (2014) Mina Tamaru et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Comparison of Five Peptide Vectors for Improved Brain Delivery of the Lysosomal Enzyme Arylsulfatase A
- (2014) A. Bockenhoff et al. JOURNAL OF NEUROSCIENCE
- A Myristoylated Cell-Penetrating Peptide Bearing a Transferrin Receptor-Targeting Sequence for Neuro-Targeted siRNA Delivery
- (2014) Pilju Youn et al. MOLECULAR PHARMACEUTICS
- Development of a general methodology for labelling peptide–morpholino oligonucleotide conjugates using alkyne–azide click chemistry
- (2013) Fazel Shabanpoor et al. CHEMICAL COMMUNICATIONS
- Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides
- (2013) Mehrdad Dirin et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier
- (2013) D. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Uptake Mechanism of the Cell-Penetrating pVEC Peptide
- (2013) Ihsan Omur Akdag et al. Journal of Chemistry
- Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA
- (2012) Peter Järver et al. Molecular Therapy-Nucleic Acids
- Functionalization with ApoE-derived peptides enhances the interaction with brain capillary endothelial cells of nanoliposomes binding amyloid-beta peptide
- (2011) Francesca Re et al. JOURNAL OF BIOTECHNOLOGY
- Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors
- (2011) Suat Cheng Tan et al. MOLECULAR BIOLOGY REPORTS
- Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model
- (2011) Francesca Re et al. Nanomedicine-Nanotechnology Biology and Medicine
- siRNA Delivery to CNS Cells using a Membrane Translocation Peptide
- (2010) Marytheresa A. Ifediba et al. BIOCONJUGATE CHEMISTRY
- Delivery of Macromolecules Using Arginine-Rich Cell-Penetrating Peptides: Ways to Overcome Endosomal Entrapment
- (2009) Ayman El-Sayed et al. AAPS Journal
- Gene Knockdowns in Adult Animals: PPMOs and Vivo-Morpholinos
- (2009) Jon Moulton et al. MOLECULES
- Insight into the role of HSPG in the cellular uptake of apolipoprotein E-derived peptide micelles and liposomes
- (2008) Eik Leupold et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
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