Article
Polymer Science
Sunny Skaria, Kenneth J. Berk
Summary: This study aimed to synthesize and characterize a novel methacrylate-functionalized calcium phosphate for use in innovative dental composites. The results showed that adding MCP improved the flexural strength and translucency of the composites, as well as promoted the surface precipitation of hydroxyapatite.
Article
Polymer Science
Fathia Rahmani, Omar Larbi Bouamrane, Amina Ben Bouabdallah, Leonard I. Atanase, Abdelkader Hellal, Aurelian Nichita Apintiliesei
Summary: Chitosan films coated with calcium phosphate were studied to mimic the formation of nanohydroxyapatite. Various testing methods confirmed the induction and control of the calcium phosphate coating. In addition, the antimicrobial activity of the phosphorylated derivatives of chitosan was evaluated, showing potential use as dental substitute materials.
Article
Biotechnology & Applied Microbiology
Hans-Juergen Ensikat, Maximilian Weigend
Summary: This article extends previous studies on the distribution and composition of biominerals in Loasaceae plant trichomes, focusing on their spatial diversity and interactions with organic substances. The research found that up to three different biominerals may be present in plant trichomes, either in pure form or in combination with organic compounds, forming composite materials.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Lotem Gotnayer, Dina Aranovich, Merav Fraenkel, Uri Yoel, Netta Vidavsky
Summary: Thyroid nodules are common findings in neck ultrasonography, but only a small percentage of them are malignant. Fine needle aspiration for cytology is indicated when ultrasound characteristics suggest TN malignancy. However, indeterminate results are common, requiring further evaluation through repeated FNAC or expensive molecular testing. This study suggests that the presence of zinc in microscopic calcifications may serve as a biomarker for TN malignancy.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Susrut Akkineni, Gregory S. Doerk, Chenyang Shi, Biao Jin, Shuai Zhang, Stefan Habelitz, James J. De Yoreo
Summary: The study demonstrates how the supramolecular structures of matrix proteins can be synthetically directed into predetermined patterns while retaining their functionality. They used block copolymer lamellar patterns to direct the assembly of peptide nanoribbons, which template calcium phosphate nucleation by creating a low-energy interface. The results show that the patterned nanoribbons maintain their structure and function, and successfully direct the formation of calcium phosphate with high fidelity.
Article
Chemistry, Physical
Jihye Lee, Adama Konate, Clement Guibert, Jessem Landoulsi
Summary: In this study, a biomimetic method for growing a hybrid calcium phosphate (CaP) - collagen coating is described. The versatility of layer-by-layer (LbL) method is explored to incorporate collagen and alkaline phosphatase (ALP), and control their organization and bioactivity. The presence of collagen fibrils in the LbL film plays a crucial role in the growth mechanism of the biomimetic mineral layer. The approach provides a straightforward way for designing biomimetic hybrid coatings in biomedical applications.
SURFACES AND INTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Clement Guibert, Jessem Landoulsi
Summary: Biomineralization is the process by which organisms produce hard inorganic matter from soft tissues, with sophisticated toolkit and biological system regulation in place. Two main views have emerged regarding the mechanism of CaP biomineralization, with one focusing on in vivo systems and the other on physicochemistry research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Yuchen Zhang, Shaoyang Ma, Jiaming Nie, Zhongbo Liu, Faming Chen, Ang Li, Dandan Pei
Summary: Bone mineralization is a complex process involving the interplay between organic and inorganic components of bone tissues. This review focuses on the evolution of mineral precursors in the bone mineralization process and highlights the tight control organisms have over each step. The connection between biomineralization and biomaterial design strategies is discussed, along with the detailed implementation of mineral precursor-based biomaterials in various bone graft materials.
Article
Chemistry, Multidisciplinary
Min-juan Shen, Chen-yu Wang, Dong-xiao Hao, Jia-xin Hao, Yi-fei Zhu, Xiao-xiao Han, Lige Tonggu, Ji-hua Chen, Kai Jiao, Franklin R. Tay, Li-na Niu
Summary: The idea that RNA can play nonbiological roles in the nanomaterial world is revolutionary. RNA molecules can self-assemble into various nanostructures and have the potential to replicate bone healing. The development of RNA-biomineral nanomachines can mimic bone formation and create an environment conducive to rapid biomineralization and osteogenesis.
ADVANCED MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Peiyu Liu, Yan Liu, Xinyi Ren, Zhifei Zhang, Xiang Zhao, Andrew P. Roberts, Yongxin Pan, Jinhua Li
Summary: The newly discovered magnetotactic spirillum XQGS-1 from Xingqinggong Lake in Xi'an City, Shaanxi Province, China, represents a novel genus of the Alphaproteobacteria class. In addition to forming magnetite crystals, XQGS-1 cells also biomineralize submicrometer calcium carbonate and calcium phosphate granules intracellularly, indicating that magnetotactic bacteria are an important microbial group for intracellular calcium carbonate and calcium phosphate biomineralization.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Kefeng Wang, Fengxiong Luo, Ling Wang, Boqing Zhang, Yujiang Fan, Xin Wang, Dingguo Xu, Xingdong Zhang
Summary: Calcium and phosphate ions play crucial roles in biomineralization, with phosphate ions being more important. The guanidyl group and surrounding carboxyl terminal groups on proteins may serve as excellent nucleation domains. The distribution of acidic/basic residues on proteins promotes the formation of large Ca and P ions clusters.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biophysics
Yuanda Liu, Jing Wang, Ming Jiang, Xueyan Li, Qinghao Zhang, Hongyan He
Summary: In this study, a hybrid membrane with biomimetic function was developed to create an angiogenesis-inductive microenvironment through the release of calcium ions, aiming to overcome the limitations of bone tissue regeneration in diabetic patients. The results showed that the hybrid membrane can enhance vascularization and bone regeneration by recruiting, proliferating, and differentiating mesenchymal stem cells and endothelial progenitors.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Shanshan Wu, Meizhou Zhang, Jie Song, Stefan Weber, Xiaoguo Liu, Chunhai Fan, Yuzhou Wu
Summary: Calcium phosphate is the most abundant biomineral in hard tissues, and the rational design and fabrication of Ca-P materials have been achieved through a particle attachment process, inheriting structural details encoded by DNA templates to enhance mechanical strength while preserving synthetic functionalities on the DNA surface.
Article
Polymer Science
R. K. Adarsh, Eva C. Das, Gopika Gopan, Remya K. Rajan, Manoj Komath
Summary: This study successfully developed a chitosan-based porous scaffold with uniformly distributed nanoparticles of calcium phosphates. Through a series of experiments, it was found that the scaffold exhibited good mechanical properties, bioactivity, and cytocompatibility, and had good adhesion with human periodontal ligament cells.
JOURNAL OF POLYMER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Anastasia Yu. Teterina, Igor V. Smirnov, Irina S. Fadeeva, Roman S. Fadeev, Polina V. Smirnova, Vladislav V. Minaychev, Margarita I. Kobyakova, Aleksandr Yu. Fedotov, Sergey M. Barinov, Vladimir S. Komlev
Summary: The study presented the synthesis of low-temperature calcium phosphate compounds with strontium substitution to improve bioactive properties, indicating the effectiveness of using strontium in OCP for enhancing biocompatibility in composite materials intended for bone repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)