The SGLT2 inhibitor empagliflozin negatively regulates IL-17/IL-23 axis-mediated inflammatory responses in T2DM with NAFLD via the AMPK/mTOR/autophagy pathway

Effect of Empagliflozin on Liver Fat in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial (E-LIFT Trial)

(2018) Mohammad Shafi Kuchay et al.   DIABETES CARE

Epidemiology of diabetes and diabetic complications in China

(2018) Ronald C. W. Ma   DIABETOLOGIA

Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission

(2018) Hao Zhou et al.   Redox Biology

Dapagliflozin and Empagliflozin Ameliorate Hepatic Dysfunction Among Chinese Subjects with Diabetes in Part Through Glycemic Improvement: A Single-Center, Retrospective, Observational Study

(2018) Paul Chi Ho Lee et al.   Diabetes Therapy

Dapagliflozin and Empagliflozin Ameliorate Hepatic Dysfunction Among Chinese Subjects with Diabetes in Part Through Glycemic Improvement: A Single-Center, Retrospective, Observational Study

(2018) Paul Chi Ho Lee et al.   Diabetes Therapy

Empagliflozin is associated with improvements in liver enzymes potentially consistent with reductions in liver fat: results from randomised trials including the EMPA-REG OUTCOME® trial

(2018) Naveed Sattar et al.   DIABETOLOGIA

Liraglutide relieves myocardial damage by promoting autophagy via AMPK-mTOR signaling pathway in zucker diabetic fatty rat

(2017) Ya Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

AMPK as a Therapeutic Target for Treating Metabolic Diseases

(2017) Emily A. Day et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME®trial

(2016) David Fitchett et al.   EUROPEAN HEART JOURNAL

The Macrophage Switch in Obesity Development

(2016) Angela Castoldi et al.   Frontiers in Immunology

The Mechanisms and Therapeutic Potential of SGLT2 Inhibitors in Diabetes Mellitus

(2015) Volker Vallon   Annual Review of Medicine

IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases

(2015) Michele W L Teng et al.   NATURE MEDICINE

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

(2015) Bernard Zinman et al.   NEW ENGLAND JOURNAL OF MEDICINE

mTORC1: Turning Off Is Just as Important as Turning On

(2014) Don Benjamin et al.   CELL

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

(2014) Hannele Yki-Järvinen   Lancet Diabetes & Endocrinology

Glucagon-Like Peptide-1 Protects Against Cardiac Microvascular Injury in Diabetes via a cAMP/PKA/Rho-Dependent Mechanism

(2013) D. Wang et al.   DIABETES

IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice

(2013) Isaac T.W. Harley et al.   HEPATOLOGY

Autophagy Regulates IL-23 Secretion and Innate T Cell Responses through Effects on IL-1 Secretion

(2012) C. Peral de Castro et al.   JOURNAL OF IMMUNOLOGY

Antagonistic control of muscle cell size by AMPK and mTORC1

(2011) Rémi Mounier et al.   CELL CYCLE

Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors

(2011) Vojo Deretic   CURRENT OPINION IN IMMUNOLOGY

Vγ4 γδ T Cell-Derived IL-17A Negatively Regulates NKT Cell Function in Con A-Induced Fulminant Hepatitis

(2011) Na Zhao et al.   JOURNAL OF IMMUNOLOGY

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings

(2010) Elizabeth M. Brunt et al.   HEPATOLOGY

Cutting Edge: Spontaneous Development of IL-17–Producing γδ T Cells in the Thymus Occurs via a TGF-β1–Dependent Mechanism

(2010) Jeong-su Do et al.   JOURNAL OF IMMUNOLOGY

Fatty liver: Role of inflammation and fatty acid nutrition

(2010) Christopher D Byrne   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark