Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell

A telomerase-responsive nanoprobe with theranostic properties in tumor cells

(2020) He-Hua Zhang et al.   TALANTA

Current scenario of indole derivatives with potential anti-drug-resistant cancer activity

(2020) Yanshu Jia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma

(2020) Wesam Ali et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue

(2020) Yao Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation

(2020) Lu Chen et al.   Nature Communications

Pyrimidine: A promising scaffold for optimization to develop the inhibitors of ABC transporters

(2020) Zhang-Xu He et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators

(2019) Silvia Dei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of novel inhibitors of phosphodiesterase 4 with 1-phenyl-3,4-dihydroisoquinoline scaffold: Structure-based drug design and fragment identification

(2019) Yixian Liao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimizing Targeted Inhibitors of P-Glycoprotein Using Computational and Structure-Guided Approaches

(2019) John G. Wise et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel virosecurinine bivalent mimetics as potent reversal agents against P-glycoprotein-mediated multidrug resistance

(2019) Wen Hou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell

(2018) Ya-Sheng Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of bifendate derivatives bearing 6,7-dihydro-dibenzo[ c,e ]azepine scaffold as potential P-glycoprotein and tumor metastasis inhibitors

(2018) Xiaoke Gu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploration of 1,2,3-triazole-pyrimidine hybrids as potent reversal agents against ABCB1-mediated multidrug resistance

(2018) Bo Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 5-Cyano-6-phenylpyrimidin Derivatives Containing an Acylurea Moiety as Orally Bioavailable Reversal Agents against P-Glycoprotein-Mediated Mutidrug Resistance

(2018) Bo Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Tetrahydroisoquinoline Derivatives Overcome Pgp Activity in Brain-Blood Barrier and Glioblastoma Multiforme in Vitro

(2018) Iris Salaroglio et al.   MOLECULES

Discovery of traditional Chinese medicine monomers and their synthetic intermediates, analogs or derivatives for battling P-gp-mediated multi-drug resistance

(2018) Xiaodong Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment

(2017) Deepali Waghray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance

(2017) Qianqian Qiu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

(2017) Brandy Verhalen et al.   NATURE

A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression

(2016) Stefano Guglielmo et al.   ChemMedChem

ABC transporters as mediators of drug resistance and contributors to cancer cell biology

(2016) Jamie I. Fletcher et al.   DRUG RESISTANCE UPDATES

Jatrophane Diterpenoids as Modulators of P-Glycoprotein-Dependent Multidrug Resistance (MDR): Advances of Structure–Activity Relationships and Discovery of Promising MDR Reversal Agents

(2016) Jianyong Zhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Marine Natural Products as Models to Circumvent Multidrug Resistance

(2016) Solida Long et al.   MOLECULES

Molecular mechanisms of drug resistance and its reversal in cancer

(2015) Melis Kartal-Yandim et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives

(2015) Iris L. K. Wong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy

(2015) Renata Silva et al.   PHARMACOLOGY & THERAPEUTICS

SAR Studies on Tetrahydroisoquinoline Derivatives: The Role of Flexibility and Bioisosterism To Raise Potency and Selectivity toward P-glycoprotein

(2014) Elena Capparelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds

(2012) A. Palmeira et al.   CURRENT MEDICINAL CHEMISTRY

Regioselective Suzuki Coupling of Dihaloheteroaromatic Compounds as a Rapid Strategy To Synthesize Potent Rigid Combretastatin Analogues

(2011) Sewan Theeramunkong et al.   JOURNAL OF MEDICINAL CHEMISTRY

ABC Efflux Pump-Based Resistance to Chemotherapy Drugs

(2009) Paul D. W. Eckford et al.   CHEMICAL REVIEWS

Novel Insight in Structure−Activity Relationship and Bioanalysis of P-Glycoprotein Targeting Highly Potent Tetrakishydroxymethyl Substituted 3,9-Diazatetraasteranes

(2008) Claudius Coburger et al.   JOURNAL OF MEDICINAL CHEMISTRY