Uncertainty in protein–ligand binding constants: asymmetric confidence intervals versus standard errors

How to measure and evaluate binding affinities

(2020) Inga Jarmoskaite et al.   eLife

Can you trust the parametric standard errors in nonlinear least squares? Yes, with provisos

(2018) Joel Tellinghuisen   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Critique of methods for estimating heats in isothermal titration calorimetry

(2018) Joel Tellinghuisen   ANALYTICAL BIOCHEMISTRY

Structural insight into allosteric modulation of protease-activated receptor 2

(2017) Robert K. Y. Cheng et al.   NATURE

On the link between conformational changes, ligand binding and heat capacity

(2016) S. Vega et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure

(2016) Gisela Schnapp et al.   JOURNAL OF MEDICINAL CHEMISTRY

Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies

(2016) Roberto Gaspari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Applications of isothermal titration calorimetry - the research and technical developments from 2011 to 2015

(2016) Robert J. Falconer   JOURNAL OF MOLECULAR RECOGNITION

Application of isothermal titration calorimetry as a tool to study natural product interactions

(2016) O. Callies et al.   NATURAL PRODUCT REPORTS

Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions

(2016) Chad A Brautigam et al.   Nature Protocols

Biophysics in drug discovery: impact, challenges and opportunities

(2016) Jean-Paul Renaud et al.   NATURE REVIEWS DRUG DISCOVERY

Structures of endothiapepsin–fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment library

(2016) Franziska U. Huschmann et al.   Acta Crystallographica Section F-Structural Biology Communications

Surface Plasmon Resonance (SPR) Biosensors in Pharmaceutical Analysis

(2015) Andreea Olaru et al.   CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY

Thermodynamics of protein–ligand interactions as a reference for computational analysis: how to assess accuracy, reliability and relevance of experimental data

(2015) Stefan G. Krimmer et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Fragment Binding Can Be Either More Enthalpy-Driven or Entropy-Driven: Crystal Structures and Residual Hydration Patterns Suggest Why

(2015) Eggert Rühmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand Binding Thermodynamics in Drug Discovery: Still a Hot Tip?

(2015) Stefan Geschwindner et al.   JOURNAL OF MEDICINAL CHEMISTRY

On the molecular basis of the high affinity binding of basic amino acids to LAOBP, a periplasmic binding protein fromSalmonella typhimurium

(2015) Nancy O. Pulido et al.   JOURNAL OF MOLECULAR RECOGNITION

High-precision, automated integration of multiple isothermal titration calorimetric thermograms: New features of NITPIC

(2015) Thomas H. Scheuermann et al.   METHODS

Single-experiment displacement assay for quantifying high-affinity binding by isothermal titration calorimetry

(2015) Georg Krainer et al.   METHODS

Bacterial protein networks: properties and functions

(2015) Athanasios Typas et al.   NATURE REVIEWS MICROBIOLOGY

Thermodynamic and Structural Characterization of Halogen Bonding in Protein–Ligand Interactions: A Case Study of PDE5 and Its Inhibitors

(2014) Jing Ren et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thermodynamic Analysis of Transition-State Features in Picomolar Inhibitors of Human 5′-Methylthioadenosine Phosphorylase

(2013) Rong Guan et al.   BIOCHEMISTRY

Surface plasmon resonance spectroscopy for characterisation of membrane protein–ligand interactions and its potential for drug discovery

(2013) Simon G. Patching   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Quantifying High-Affinity Binding of Hydrophobic Ligands by Isothermal Titration Calorimetry

(2012) Georg Krainer et al.   ANALYTICAL CHEMISTRY

Revisiting the optimal cvalue for isothermal titration calorimetry

(2011) Jana Broecker et al.   ANALYTICAL BIOCHEMISTRY

Nonlinear least-squares data fitting in Excel spreadsheets

(2010) Gerdi Kemmer et al.   Nature Protocols

Assessing compound binding to the Eg5 motor domain using a thermal shift assay

(2009) Patricia A. McDonnell et al.   ANALYTICAL BIOCHEMISTRY

Adding calorimetric data to decision making in lead discovery: a hot tip

(2009) John E. Ladbury et al.   NATURE REVIEWS DRUG DISCOVERY

Calorimetry and Thermodynamics in Drug Design

(2008) Jonathan B. Chaires   Annual Review of Biophysics

A Quantitative Model of Thermal Stabilization and Destabilization of Proteins by Ligands

(2008) Piotras Cimmperman et al.   BIOPHYSICAL JOURNAL

Isothermal Titration Calorimetry Reveals Differential Binding Thermodynamics of Variable Region-identical Antibodies Differing in Constant Region for a Univalent Ligand

(2008) Tarun K. Dam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isothermal titration calorimetry of RNA

(2008) Nilshad N. Salim et al.   METHODS