Article
Multidisciplinary Sciences
Zhaoqian Wang, Ha Dang, Moushimi Amaya, Yan Xu, Randy Yin, Lianying Yan, Andrew C. Hickey, Edward J. Annand, Bethany A. Horsburgh, Peter A. Reid, Ina Smith, John-Sebastian Eden, Kai Xu, Christopher C. Broder, David Veesler
Summary: A new variant of Hendra virus, HeV-g2, with significant genetic divergence from the original strain, has been discovered in regions of Australia previously not considered at risk for HeV spillover. Despite the genetic differences, HeV-g2 retains similar receptor tropism and antigenic properties as the original strain. A tetravalent monoclonal antibody mixture has been formulated, capable of neutralizing both HeV and HeV-g2, providing a potential treatment option for HNV infections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Thomas W. Geisbert, Kathryn Bobb, Viktoriya Borisevich, Joan B. Geisbert, Krystle N. Agans, Robert W. Cross, Abhishek N. Prasad, Karla A. Fenton, Hao Yu, Timothy R. Fouts, Christopher C. Broder, Antony S. Dimitrov
Summary: A human subunit vaccine based on the attachment glycoprotein of Hendra virus was found to provide protection against both Nipah and Hendra viruses in a nonhuman primate model, starting as early as 7 days post immunization with a low dose. This vaccine could potentially serve as an efficient emergency tool to control the spread of Nipah disease during outbreaks.
Article
Immunology
Neeltje van Doremalen, Victoria A. A. Avanzato, Kerry Goldin, Friederike Feldmann, Jonathan E. E. Schulz, Elaine Haddock, Atsushi Okumura, Jamie Lovaglio, Patrick W. W. Hanley, Kathleen Cordova, Greg Saturday, Emmie de Wit, Teresa Lambe, Sarah C. C. Gilbert, Vincent J. J. Munster
Summary: ChAdOx1 NiV vaccine shows strong protection in the lethal African green monkey NiV challenge model, preventing virus replication and inducing a robust immune response.
Article
Veterinary Sciences
Wenjun Zhu, Bradley Pickering, Greg Smith, Mathieu Pinette, Thang Truong, Shawn Babiuk, Darwyn Kobasa, Logan Banadyga, Ming Yang
Summary: A competitive enzyme-linked immunosorbent assay (cELISA) using a monoclonal antibody (mAb) and recombinant NiV glycoprotein (G) was developed and evaluated for the detection of Nipah virus and Hendra virus. The cELISA showed comparable or better results than the commonly used plaque reduction neutralization test (PRNT), making it a suitable screening test for these viruses.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Julien Cappelle, Neil Furey, Thavry Hoem, Tey Putita Ou, Thona Lim, Vibol Hul, Oudam Heng, Veronique Chevalier, Philippe Dussart, Veasna Duong
Summary: Recent studies have shown that coronaviruses are widely circulated in Southeast Asian bat species, with indications that the SARS-CoV-2 virus may have originated in rhinolophid bats in the region. The research from Cambodia indicates a correlation between positive coronavirus detections and juvenile and immature bats, suggesting seasonal patterns in CoV circulation. Long-term monitoring and understanding of bat ecology in Southeast Asia are needed for biodiversity conservation and public health reasons.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Mingqing Lu, Yanfeng Yao, Xuekai Zhang, Hang Liu, Ge Gao, Yun Peng, Miaoyu Chen, Jiaxuan Zhao, Xiaoyu Zhang, Chunhong Yin, Weiwei Guo, Peipei Yang, Xue Hu, Juhong Rao, Entao Li, Tong Chen, Sandra Chiu, Gary Wong, Zhiming Yuan, Jiaming Lan, Chao Shan
Summary: A recombinant chimpanzee adenovirus-based vaccine and a DNA vaccine were developed to protect against Nipah virus infection. The vaccines induced strong and sustained antibody production and an effective T-cell response in mice. Syrian golden hamsters immunized with these vaccines were completely protected against a lethal Nipah virus challenge. The results suggest that these vaccines are promising candidates for further development.
Review
Microbiology
Sabahat Gazal, Neelesh Sharma, Sundus Gazal, Mehak Tikoo, Deep Shikha, Gulzar Ahmed Badroo, Mohd Rashid, Sung-Jin Lee
Summary: Nipah and Hendra viruses are deadly zoonotic diseases caused by paramyxoviruses. They are primarily transmitted from bats to pigs and horses, and then to humans, resulting in severe respiratory and neurological symptoms. Due to their high pathogenicity, pandemic potential, and lack of effective treatments and vaccines, research on these viruses is highly important.
Editorial Material
Immunology
Shania Sanchez, Hinh Ly
Summary: A new virus called Langya henipavirus (LayV) has been found in Shandong and Henan provinces, China, infecting 35 people from April 2018 to August 2021. It is closely related to other known henipaviruses (Nipah and Hendra viruses) that can result in up to 70% human fatality. Although LayV has not been proven fatal in humans or transmitted human-to-human, it is an RNA virus that can genetically evolve in infected hosts (e.g. shrews) and infect humans (e.g. farmers in close contact with shrews), making it important to remain vigilant about this new viral outbreak.
Review
Infectious Diseases
Raul Gomez Roman, Nadia Tornieporth, Neil George Cherian, Amy C. Shurtleff, Maina L'Azou Jackson, Debra Yeskey, Adam Hacker, Eric Mungai, Tung Thanh Le
Summary: Henipaviruses, including Nipah virus, are considered pathogens with notable epidemic potential due to their high pathogenicity and the lack of specific medical countermeasures. Innovative strategies are necessary to address the sporadic and unpredictable nature of henipavirus outbreaks. Stronger partnerships with scientific institutions and regulatory authorities in low-income and middle-income countries are essential to inform appropriate investments and development of strategies for the equitable use of multiple medical countermeasures.
LANCET INFECTIOUS DISEASES
(2022)
Article
Virology
Camilla M. Donnelly, Olivia A. Vogel, Megan R. Edwards, Paige E. Taylor, Justin A. Roby, Jade K. Forwood, Christopher F. Basler
Summary: Nipah and Hendra viruses are highly pathogenic viruses that cause severe respiratory disease and encephalitis. This study investigates the interaction between viral proteins and cellular structures to gain a better understanding of viral transmission and develop potential therapeutics.
Article
Immunology
Xiaoyan Huang, Yaohui Li, Ruihua Li, Shaoyan Wang, Lu Yang, Shuyi Wang, Ying Yin, Xiaodong Zai, Jun Zhang, Junjie Xu
Summary: The study demonstrates that recombinant vaccine candidates using replication-defective adenovirus vector to deliver NiV attachment glycoprotein can effectively induce specific humoral and cellular immune responses in mice. The Ad5-NiVGe vaccine candidate elicited the strongest immune responses after a single-dose immunization. Additionally, a potent conserved T-cell epitope shared by NiV and HeV was identified, providing valuable information on HNVs-specific cellular immunity mechanism.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Microbiology
Hongzhao Li, Ji-Young V. Kim, Bradley S. Pickering
Summary: This article provides a concise update on the epidemiology of Hendra virus (HeV) and Nipah virus (NiV), two zoonotic pathogens that cause severe neurological and respiratory diseases. It discusses the natural reservoir hosts of these viruses, transmission pathways, and the role of intermediate hosts in disease spread.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Virology
Ming Yang, Wenjun Zhu, Thang Truong, Bradley Pickering, Shawn Babiuk, Darwyn Kobasa, Logan Banadyga
Summary: In this study, a detection method for Nipah virus (NiV) and Hendra virus (HeV) was developed, using ephrin B2 as the capture ligand and specific monoclonal antibodies as detection reagents. This method enables rapid and accurate differentiation between these two viruses.
Article
Immunology
Kim Halpin, Kerryne Graham, Peter A. Durr
Summary: The Hendra virus (HeV) vaccine, developed for horses in Australia, indirectly protects humans by preventing horse infection. The vaccine has shown good performance in the field, with horses having high neutralizing titres after receiving at least three doses of vaccination.
Article
Virology
Said Mougari, Claudia Gonzalez, Olivier Reynard, Branka Horvat
Summary: Bats serve as natural hosts for many zoonotic viruses and have evolved mechanisms to tolerate and control viral infections, preventing both virus expansion and excessive immune response.
CURRENT OPINION IN VIROLOGY
(2022)
Article
Virology
Shu Pin Yu, Kien Chai Ong, David Perera, Kum Thong Wong
Article
Clinical Neurology
Tzeh Long Fu, Kien Chai Ong, Soon Hao Tan, Kum Thong Wong
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2019)
Article
Microbiology
Han Kang Tee, Chee Wah Tan, Thinesshwary Yogarajah, Michelle Hui Pheng Lee, Hann Juang Chai, Nur Aziah Hanapi, Siti R. Yusof, Kien Chai Ong, Vannajan Sanghiran Lee, I-Ching Sam, Yoke Fun Chan
Article
Pathology
Y. T. Hooi, K. C. Ong, S. H. Tan, D. Perera, K. T. Wong
JOURNAL OF COMPARATIVE PATHOLOGY
(2020)
Article
Medicine, Research & Experimental
Yuan Teng Hooi, Kien Chai Ong, Soon Hao Tan, David Perera, Kum Thong Wong
LABORATORY INVESTIGATION
(2020)
Article
Biochemistry & Molecular Biology
Devi Nallappan, Kien Chai Ong, Uma Devi Palanisamy, Kek Heng Chua, Umah Rani Kuppusamy
Summary: This study found that a fraction of myricetin derivatives (MD) from Syzygium malaccense leaf extract has preventive and therapeutic effects on obesity, hyperglycemia, and oxidative stress induced by a high-fat diet (HFD).
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Optics
Waldo Udos, Cheong-Weng Ooi, Soon-Hao Tan, Kok-Sing Lim, Yen Jie Ee, Kien Chai Ong, Harith Ahmad
Summary: This work demonstrated a biosensor based on SPR-TFBG for detecting Enterovirus A71, improving accuracy and specificity through biofunctionalization, and reducing refractive index noise to minimize interference from unknown substances.
Article
Immunology
Michelle Hui Pheng Lee, Chee Wah Tan, Han Kang Tee, Kien Chai Ong, I-Ching Sam, Yoke Fun Chan
Summary: The study aimed to develop a live-attenuated vaccine for EV-A71 by codon deoptimization and codon-pair deoptimization. The CD X and CPD X vaccine candidates elicited good neutralizing antibodies, conferred immune protection, making them promising candidates for EV-A71.
Article
Biotechnology & Applied Microbiology
Hui Yeng Yeannie Yap, Boon Hong Kong, Chee Sum Alvin Yap, Kien Chai Ong, Rosnah Binti Zain, Soon Hao Tan, Zuraiza Mohamad Zaini, Szu Ting Ng, Chon Seng Tan, Shin Yee Fung
Summary: This study investigates the anti-oral cancer potential of Tiger milk mushroom sclerotia extract. The results show that the extract inhibits the growth of human oral cancer cell lines and regulates molecules associated with the tumor necrosis factor pathway. The extract induces apoptosis and cell cycle arrest, demonstrating its anti-cancer properties.
FOOD TECHNOLOGY AND BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Kien Chai Ong, Khong Ying Ng, Chiu Wan Ng, Soon Hao Tan, Woon Li Teo, Norain Karim, Shalini Kumar, Kum Thong Wong
Summary: Neuronal infection appears to play a more important role than vasculopathy-induced microinfarction in acute NiV encephalitis.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Shu Pin Yu, Kien Chai Ong, Soon Hao Tan, David Perera, Kum Thong Wong
Article
Pathology
Jia Shin Jessica Tan, Kien Chai Ong, Diana Bee-Lan Ong, Yuan Seng Wu, Azad Razack, Shanggar Kuppusamy, Jasmine Lim, Anthony Rhodes
MALAYSIAN JOURNAL OF PATHOLOGY
(2019)
Article
Multidisciplinary Sciences
Pinn Tsin Isabel Yee, Soon Hao Tan, Kien Chai Ong, Kuan Onn Tan, Kum Thong Wong, Sharifah Syed Hassan, Chit Laa Poh
SCIENTIFIC REPORTS
(2019)
Meeting Abstract
Clinical Neurology
Kum Thong Wong, Tzeh Long Fu, Kien Chai Ong, Soon Hao Tan
Meeting Abstract
Clinical Neurology
Shu Pin Yu, Kien Chai Ong, Soon Hao Tan, Tomohiro Ishikawa, Kum Thong Wong