Consequences of recurrent hypoglycaemia on brain function in diabetes

A randomised controlled study of high intensity exercise as a dishabituating stimulus to improve hypoglycaemia awareness in people with type 1 diabetes: a proof-of-concept study

(2020) Catriona M. Farrell et al.   DIABETOLOGIA

Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management

(2019) Stephanie A Amiel et al.   Lancet Diabetes & Endocrinology

Central Mechanisms of Glucose Sensing and Counterregulation in Defense of Hypoglycemia

(2019) Sarah Stanley et al.   ENDOCRINE REVIEWS

Recurrent non-severe hypoglycemia exacerbates imbalance of mitochondrial homeostasis leading to synapse injury and cognitive deficit in diabetes

(2018) Yu Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Impaired hypoglycaemia awareness in type 1 diabetes: lessons from the lab

(2018) Alison D. McNeilly et al.   DIABETOLOGIA

Glycaemic variability in diabetes: clinical and therapeutic implications

(2018) Antonio Ceriello et al.   Lancet Diabetes & Endocrinology

Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes

(2018) Ali J. Chakera et al.   Molecular Metabolism

Type 1 Diabetes and Impaired Awareness of Hypoglycemia Are Associated with Reduced Brain Gray Matter Volumes

(2017) Petr Bednarik et al.   Frontiers in Neuroscience

Nrf2-Mediated Neuroprotection Against Recurrent Hypoglycemia Is Insufficient to Prevent Cognitive Impairment in a Rodent Model of Type 1 Diabetes

(2016) Alison D. McNeilly et al.   DIABETES

Brain Lactate Concentration Falls in Response to Hypoglycemia in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia

(2016) Evita C. Wiegers et al.   DIABETES

Glucose concentrations of less than 3.0 mmol/l (54 mg/dl) should be reported in clinical trials: a joint position statement of the American Diabetes Association and the Europian Association for the Study of Diabetes

(2016)   DIABETOLOGIA

Brain glucose metabolism during hypoglycemia in type 1 diabetes: insights from functional and metabolic neuroimaging studies

(2015) Hanne M. M. Rooijackers et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Diazoxide Improves Hormonal Counterregulatory Responses to Acute Hypoglycemia in Long-standing Type 1 Diabetes

(2015) Priya S. George et al.   DIABETES

Lactate-Induced Release of GABA in the Ventromedial Hypothalamus Contributes to Counterregulatory Failure in Recurrent Hypoglycemia and Diabetes

(2013) O. Chan et al.   DIABETES

Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia

(2013) Raimund I. Herzog et al.   JOURNAL OF CLINICAL INVESTIGATION

Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour

(2012) C. Beall et al.   DIABETOLOGIA

Diabetes and cognitive dysfunction

(2012) Rory J McCrimmon et al.   LANCET

Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance

(2012) Susana Cardoso et al.   NEUROBIOLOGY OF DISEASE

The physiology and pathophysiology of the neural control of the counterregulatory response

(2011) Craig Beall et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Increased GABAergic Output in the Ventromedial Hypothalamus Contributes to Impaired Hypoglycemic Counterregulation in Diabetic Rats

(2011) O. Chan et al.   DIABETES

Recurrent hypoglycemia increases hypothalamic glucose phosphorylation activity in rats

(2010) Mayowa A. Osundiji et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Diabetes increases brain damage caused by severe hypoglycemia

(2009) Adam J. Bree et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sweet talk in the brain: Glucosensing, neural networks, and hypoglycemic counterregulation

(2009) Alan G. Watts et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Bringing Light to the Dark Side of Insulin: A Journey Across the Blood-Brain Barrier

(2008) R. S. Sherwin   DIABETES

Prior hypoglycemia enhances glucose responsiveness in some ventromedial hypothalamic glucosensing neurons

(2007) Ling Kang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY