RNA helicases are hubs that orchestrate exosome-dependent 3′–5′ decay

A Two-Layered Targeting Mechanism Underlies Nuclear RNA Sorting by the Human Exosome

(2020) Guifen Wu et al.   Cell Reports

Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness

(2020) Anne Slavotinek et al.   HUMAN MOLECULAR GENETICS

NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction

(2019) Jianshu Wang et al.   GENES & DEVELOPMENT

The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs

(2019) Mahesh Lingaraju et al.   Nature Communications

SnapShot: The RNA Exosome

(2019) M. Rhyan Puno et al.   CELL

ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation

(2019) Dustin L. Gable et al.   GENES & DEVELOPMENT

Towards a mechanistic understanding of cellular processes by cryoEM

(2019) Adrian Pascal Nievergelt et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex

(2018) Eva-Maria Weick et al.   CELL

Genetic and Structural Analysis of a SKIV2L Mutation Causing Tricho-hepato-enteric Syndrome

(2018) Iddo Vardi et al.   DIGESTIVE DISEASES AND SCIENCES

Tricho-Hepato-Enteric Syndrome mutation update: Mutations spectrum of TTC37 and SKIV2L , clinical analysis and future prospects

(2018) Patrice Bourgeois et al.   HUMAN MUTATION

Characteristics and Outcome of ROS1 -Positive Non–Small Cell Lung Cancer Patients in Routine Clinical Practice

(2018) Sehhoon Park et al.   Journal of Thoracic Oncology

Structural basis for MTR4–ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex

(2018) M. Rhyan Puno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the nuclear exosome captured on a maturing preribosome

(2018) Jan Michael Schuller et al.   SCIENCE

Distinct and evolutionary conserved structural features of the human nuclear exosome complex

(2018) Piotr Gerlach et al.   eLife

An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression

(2017) Koichi Ogami et al.   GENES & DEVELOPMENT

Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53

(2017) Sebastian Falk et al.   RNA

Attacked from All Sides: RNA Decay in Antiviral Defense

(2017) Jerome Molleston et al.   Viruses-Basel

Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase

(2017) Elizabeth V Wasmuth et al.   eLife

Multiple Myeloma Genomics: A Systematic Review

(2017) Casey J. Weaver et al.   Seminars in Oncology Nursing

CryoEM structure of yeast cytoplasmic exosome complex

(2016) Jun-Jie Liu et al.   CELL RESEARCH

Identification ofZCCHC8as fusion partner ofROS1in a case of congenital glioblastoma multiforme with a t(6;12)(q21;q24.3)

(2016) Mariela C. Coccé et al.   GENES CHROMOSOMES & CANCER

Nuclear RNA Exosome at 3.1 Å Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3

(2016) John C. Zinder et al.   MOLECULAR CELL

Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex

(2016) Eva Kowalinski et al.   MOLECULAR CELL

Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts

(2016) Nicola Meola et al.   MOLECULAR CELL

The regulation and functions of the nuclear RNA exosome complex

(2016) Cornelia Kilchert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The cryo-EM structure of a ribosome–Ski2-Ski3-Ski8 helicase complex

(2016) Christian Schmidt et al.   SCIENCE

The Exosome Is Recruited to RNA Substrates through Specific Adaptor Proteins

(2015) Matthias Thoms et al.   CELL

RNA degradation paths in a 12-subunit nuclear exosome complex

(2015) Debora Lika Makino et al.   NATURE

Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases

(2015) Eva Kowalinski et al.   STRUCTURE

The eukaryotic RNA exosome

(2014) Kurt Januszyk et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The exosome‐binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase

(2014) Benjamin Schuch et al.   EMBO JOURNAL

The Molecular Architecture of the TRAMP Complex Reveals the Organization and Interplay of Its Two Catalytic Activities

(2014) Sebastian Falk et al.   MOLECULAR CELL

Structure of an Rrp6–RNA exosome complex bound to poly(A) RNA

(2014) Elizabeth V. Wasmuth et al.   NATURE

Kinase fusions are frequent in Spitz tumours and spitzoid melanomas

(2014) Thomas Wiesner et al.   Nature Communications

The Yeast Ski Complex: Crystal Structure and RNA Channeling to the Exosome Complex

(2013) Felix Halbach et al.   CELL

Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex

(2013) Debora Lika Makino et al.   NATURE

Syndromic diarrhea/Tricho-hepato-enteric syndrome

(2013) Alexandre Fabre et al.   Orphanet Journal of Rare Diseases

Threading the barrel of the RNA exosome

(2013) Claudia Schneider et al.   TRENDS IN BIOCHEMICAL SCIENCES

SKIV2L Mutations Cause Syndromic Diarrhea, or Trichohepatoenteric Syndrome

(2012) Alexandre Fabre et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ski2-like RNA helicase structures

(2012) Sean J. Johnson et al.   RNA Biology

Mutations in TTC37 Cause Trichohepatoenteric Syndrome (Phenotypic Diarrhea of Infancy)

(2010) Jane Louise Hartley et al.   GASTROENTEROLOGY

Novel mutations in TTC37 associated with tricho-hepato-enteric syndrome

(2010) Alexandre Fabre et al.   HUMAN MUTATION

Structural analysis reveals the characteristic features of Mtr4, a DExH helicase involved in nuclear RNA processing and surveillance

(2010) J. R. Weir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA