Dominant mutations in CHK1 cause pronuclear fusion failure and zygote arrest that can be rescued by CHK1 inhibitor

Intramolecular autoinhibition of checkpoint kinase 1 is mediated by conserved basic motifs of the C-terminal kinase–associated 1 domain

(2017) Ryan P. Emptage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase I clinical trial of gemcitabine (GEM) in combination with PF-00477736 (PF-736), a selective inhibitor of CHK1 kinase.

(2017) N. Brega et al.   JOURNAL OF CLINICAL ONCOLOGY

Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease

(2016) Louise A. Hyslop et al.   NATURE

DNA damage control: regulation and functions of checkpoint kinase 1

(2015) Veronique A. J. Smits et al.   FEBS Journal

Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells

(2013) Liying Yan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Coupling Cellular Localization and Function of Checkpoint Kinase 1 (Chk1) in Checkpoints and Cell Viability

(2012) Jingna Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

National, Regional, and Global Trends in Infertility Prevalence Since 1990: A Systematic Analysis of 277 Health Surveys

(2012) Maya N. Mascarenhas et al.   PLOS MEDICINE

Human zygote morphological indicators of higher rate of arrest at the first cleavage stage

(2010) Raquel Blanes Zamora et al.   ZYGOTE

Permanent embryo arrest: molecular and cellular concepts

(2008) D.H. Betts et al.   MOLECULAR HUMAN REPRODUCTION