DNA damage control: regulation and functions of checkpoint kinase 1

The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle

(2015) I. A. Shaltiel et al.   JOURNAL OF CELL SCIENCE

ATR and a Chk1-Aurora B pathway coordinate postmitotic genome surveillance with cytokinetic abscission

(2015) Douglas R. Mackay et al.   MOLECULAR BIOLOGY OF THE CELL

Interaction of Chk1 with Treslin Negatively Regulates the Initiation of Chromosomal DNA Replication

(2015) Cai Guo et al.   MOLECULAR CELL

Tight Chk1 Levels Control Replication Cluster Activation in Xenopus

(2015) Marie Platel et al.   PLoS One

Loss of autophagy causes a synthetic lethal deficiency in DNA repair

(2015) Emma Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage

(2015) Caroline Park et al.   Nature Communications

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage

(2015) Eun-Yeung Gong et al.   Scientific Reports

USP7 controls Chk1 protein stability by direct deubiquitination

(2014) Ignacio Alonso-de Vega et al.   CELL CYCLE

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

(2014) Peijing Zhang et al.   NATURE CELL BIOLOGY

USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination

(2014) Y Martín et al.   ONCOGENE

Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing

(2014) Hongqing Liang et al.   Nature Communications

Regulatory motifs in Chk1

(2013) Michael L. Caparelli et al.   CELL CYCLE

Pim kinases phosphorylate Chk1 and regulate its functions in acute myeloid leukemia

(2013) L L Yuan et al.   LEUKEMIA

Coupling Cellular Localization and Function of Checkpoint Kinase 1 (Chk1) in Checkpoints and Cell Viability

(2012) Jingna Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRL4CDT2 Targets CHK1 for PCNA-Independent Destruction

(2012) J. Huh et al.   MOLECULAR AND CELLULAR BIOLOGY

P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation

(2012) Ping Li et al.   MOLECULAR BIOLOGY OF THE CELL

Akt1 inhibits homologous recombination in Brca1-deficient cells by blocking the Chk1-Rad51 pathway

(2012) Y Jia et al.   ONCOGENE

Regulation of DNA Replication through Sld3-Dpb11 Interaction Is Conserved from Yeast to Humans

(2011) Dominik Boos et al.   CURRENT BIOLOGY

Phosphorylation at serine 331 is required for Aurora B activation

(2011) Eleni Petsalaki et al.   JOURNAL OF CELL BIOLOGY

Nuclear Chk1 prevents premature mitotic entry

(2011) M. Matsuyama et al.   JOURNAL OF CELL SCIENCE

Cdk-mediated phosphorylation of Chk1 is required for efficient activation and full checkpoint proficiency in response to DNA damage

(2011) N Xu et al.   ONCOGENE

Structure-Specific DNA Endonuclease Mus81/Eme1 Generates DNA Damage Caused by Chk1 Inactivation

(2011) Josep V. Forment et al.   PLoS One

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1

(2011) Melanie Blasius et al.   GENOME BIOLOGY

Kinases Charging to the Membrane

(2010) Michael A. Hadders et al.   CELL

Clusters, factories and domains

(2010) Peter J. Gillespie et al.   CELL CYCLE

14-3-3γ mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage

(2010) Kousuke Kasahara et al.   EMBO JOURNAL

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories

(2010) Xin Quan Ge et al.   JOURNAL OF CELL BIOLOGY

DDB1 Targets Chk1 to the Cul4 E3 Ligase Complex in Normal Cycling Cells and in Cells Experiencing Replication Stress

(2009) V. Leung-Pineda et al.   CANCER RESEARCH

Novel Positive Feedback Loop between Cdk1 and Chk1 in the Nucleus during G2/M Transition

(2009) Masato Enomoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP7 counteracts SCFβTrCP- but not APCCdh1-mediated proteolysis of Claspin

(2009) Helene Faustrup et al.   JOURNAL OF CELL BIOLOGY

The decision to enter mitosis: feedback and redundancy in the mitotic entry network

(2009) Arne Lindqvist et al.   JOURNAL OF CELL BIOLOGY

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity

(2009) M Walker et al.   ONCOGENE

The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis

(2009) S. Peddibhotla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression

(2008) Midori Shimada et al.   CELL

A Conserved Proliferating Cell Nuclear Antigen-interacting Protein Sequence in Chk1 Is Required for Checkpoint Function

(2008) Jennifer Scorah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Chk1 by Its C-terminal Domain

(2008) Ana Kosoy et al.   MOLECULAR BIOLOGY OF THE CELL

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

(2008) D. Wilsker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA