Astrocyte senescence and SASP in neurodegeneration: tau joins the loop

Astrocyte senescence promotes glutamate toxicity in cortical neurons

(2020) Chandani Limbad et al.   PLoS One

Radiation-induced astrocyte senescence is rescued by Δ133p53

(2019) Casmir Turnquist et al.   NEURO-ONCOLOGY

Senescence-associated-β-galactosidase staining following traumatic brain injury in the mouse cerebrum

(2019) Tadasuke Tominaga et al.   PLoS One

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

(2019) Ilie-Cosmin Stancu et al.   ACTA NEUROPATHOLOGICA

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

(2019) Wenjuan Zhang et al.   eLife

The Post-amyloid Era in Alzheimer's Disease: Trust Your Gut Feeling

(2019) Carolina Osorio et al.   Frontiers in Aging Neuroscience

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

(2018) Darren J. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular Senescence and Inflammaging in Age-Related Diseases

(2018) Fabiola Olivieri et al.   MEDIATORS OF INFLAMMATION

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

(2018) Lewis D. Evans et al.   Cell Reports

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

Dephosphorylated rather than hyperphosphorylated Tau triggers a pro-inflammatory profile in microglia through the p38 MAPK pathway

(2018) Juan Ramón Perea et al.   EXPERIMENTAL NEUROLOGY

Tau Oligomers and Fibrils Induce Activation of Microglial Cells

(2018) Inelia Morales et al.   JOURNAL OF ALZHEIMERS DISEASE

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking

(2017) Youssra K. Al-Hilaly et al.   JOURNAL OF MOLECULAR BIOLOGY

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

(2017) Sneha Narasimhan et al.   JOURNAL OF NEUROSCIENCE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Alzheimer’s disease, dementia, and stem cell therapy

(2017) Thomas Duncan et al.   Stem Cell Research & Therapy

p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration

(2016) C Turnquist et al.   CELL DEATH AND DIFFERENTIATION

Tau Structures

(2016) Jesus Avila et al.   Frontiers in Aging Neuroscience

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

(2016) M. Fá et al.   Scientific Reports

p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage

(2015) Lu Gong et al.   CELL RESEARCH

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease

(2015) Charles R. Harrington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

(2015) Marie Violet et al.   NEUROBIOLOGY OF DISEASE

Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?

(2015) Seyedeh Maryam Alavi Naini et al.   Oxidative Medicine and Cellular Longevity

Tau immunotherapy for Alzheimer's disease

(2015) Jan Torleif Pedersen et al.   TRENDS IN MOLECULAR MEDICINE

Advances in Therapeutics for Neurodegenerative Tauopathies: Moving toward the Specific Targeting of the Most Toxic Tau Species

(2014) Julia E. Gerson et al.   ACS Chemical Neuroscience

P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway

(2014) Holly C. Hunsberger et al.   JOURNAL OF NEUROCHEMISTRY

Tau promotes neurodegeneration through global chromatin relaxation

(2014) Bess Frost et al.   NATURE NEUROSCIENCE

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes

(2013) Abdul M. Mondal et al.   JOURNAL OF CLINICAL INVESTIGATION

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Tau oligomers and tau toxicity in neurodegenerative disease

(2012) Sarah M. Ward et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

(2012) Najla Kfoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Propranolol restores cognitive deficits and improves amyloid and Tau pathologies in a senescence-accelerated mouse model

(2012) Marta Dobarro et al.   NEUROPHARMACOLOGY

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease

(2012) Jane J. Sohn et al.   PLoS One

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

(2011) Antero Salminen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice

(2011) Magali Dumont et al.   FASEB JOURNAL

Cellular senescence and tumor suppressor gene p16

(2011) Hani Rayess et al.   INTERNATIONAL JOURNAL OF CANCER

Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model

(2011) Lourdes Orejana et al.   NEUROBIOLOGY OF AGING

Role of p53 in Neurodegenerative Diseases

(2011) J. Robert Chang et al.   Neurodegenerative Diseases

Cell-Mediated Neuroprotection in a Mouse Model of Human Tauopathy

(2010) D. W. Hampton et al.   JOURNAL OF NEUROSCIENCE

New evidences on Tau–DNA interactions and relevance to neurodegeneration

(2010) Vasudevaraju Padmaraju et al.   NEUROCHEMISTRY INTERNATIONAL

Glutamate receptors, neurotoxicity and neurodegeneration

(2010) Anthony Lau et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

DNA Damage and Repair in Alzheimers Disease

(2009) Fabio Coppede et al.   Current Alzheimer Research

SASP reflects senescence

(2009) Andrew R J Young et al.   EMBO REPORTS

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence

(2009) Kaori Fujita et al.   NATURE CELL BIOLOGY

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Tumor Suppressive Functions of p53

(2009) J. T. Zilfou et al.   Cold Spring Harbor Perspectives in Biology