Article
Biochemistry & Molecular Biology
Birandra K. Sinha, Erik J. Tokar, Carl D. Bortner
Summary: NCX4040 exhibits cytotoxicity against ovarian tumor cells and induces apoptosis and oxidative stress. Sensitivity to NCX4040 and DNA damage repair efficiency vary among different cell lines, and the cytotoxicity may be mediated by peroxynitrite.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agronomy
Shiwen Liu, Shuhua Zhu, Guangqin Jing
Summary: Excessive reactive oxygen species (ROS) during storage can lead to oxidative damage to mitochondrial DNA (mtDNA) in peaches, exacerbating fruit damage. Nitric oxide (NO) has been found to help maintain the storage quality of peaches. This study investigates the effects of NO on mtDNA damage and repair, focusing on the base excision repair (BER) pathway. The results show that NO reduces ROS levels and oxidative damage markers in mitochondria, increases mtDNA copy number, and enhances the BER pathway, leading to improved repair efficiency and maintenance of mtDNA integrity.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Deepavali Chakravarti, Rumi Lee, Asha S. Multani, Andrea Santoni, Zachery Keith, Wen-Hao Hsu, Kyle Chang, Laura Reyes, Asif Rashid, Chang-Jiun Wu, Jun Li, Jiexin Zhang, Hong Seok Shim, Krishna Chandra, Pingna Deng, Denise J. Spring, Ole Haagen Nielsen, Lene Buhl Riis, Kavya Kelagere Mayigegowda, Sarah E. Blutt, Jianhua Zhang, Mamoun Younes, Andrew DuPont, Selvi Thirumurthi, Eduardo Vilar, Mary K. Estes, Simona Colla, Noah F. Shroyer, Ronald A. DePinho
Summary: The study explores the role of the ATM/YAP1/pro-IL-18 pathway in the pathogenesis of inflammatory bowel disease (IBD), particularly in older-onset cases. Telomere dysfunction in intestinal epithelium may initiate the inflammatory process in IBD, suggesting new therapeutic interventions for the disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Srikruthi S. Krishnachaitanya, Max Liu, Ken Fujise, Qingjie Li
Summary: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a group of chronic gastrointestinal inflammatory conditions that cause multiple complications. MicroRNA (miRNA) plays a significant role in the pathogenesis and complications of IBD, particularly in chronic inflammatory pathways. In addition to its involvement in the progression of colorectal cancer, miRNA is also associated with various extraintestinal complications in IBD, such as cardiovascular diseases, neuropsychiatric conditions, and musculoskeletal, dermatologic, ocular, and hepatobiliary complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Hiroshi Ebata, Tze Mun Loo, Akiko Takahashi
Summary: This review summarizes the unique characteristics of cancer cells, such as high proliferation and aberrant DNA damage response, and the role of telomerase and ALT in cancer regulation. It focuses on their noncanonical functions beyond telomere maintenance, as well as intercellular communication in the tumor microenvironment (TME) through the cGAS-STING pathway. Understanding the functional connection between telomere-related molecules and TME regulation is crucial for developing cancer therapeutics targeting specific pathways.
Article
Multidisciplinary Sciences
Stefanie Dichtl, Laura Lindenthal, Leonie Zeitler, Kristina Behnke, Daniela Schloesser, Birgit Strobl, Juergen Scheller, Karim C. El Kasmi, Peter J. Murray
Summary: Lactate, a product of Warburg-type metabolism in inflammatory macrophages, has been shown to modify histones and promote gene expression related to tissue repair. The presence of IL6 and Arg1 is correlated with Kla, suggesting a metabolic rewiring in macrophages under inflammatory stress.
Article
Biochemistry & Molecular Biology
Qilang Wei, Zhenwei Yan, Yifan Xiong, Zhongming Fang
Summary: The study reveals that the amino acid transporter OsAAP3 is involved in the regulation of lesion mimic and leaf senescence in rice plants. Altering the expression of OsAAP3 can initiate the nitric oxide signaling pathway, impacting various physiological indicators in rice leaves and ultimately leading to cell death and leaf senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Hossam G. Tohamy, Mahmoud S. El-Neweshy, Mohamed Mohamed Soliman, Samy Sayed, Mustafa Shukry, Heba I. Ghamry, Hoda Abd-Ellatieff
Summary: The study found that royal jelly has a protective effect against HDU-induced hepatic injury by maintaining the hepatic oxidative/antioxidative status, reducing inflammation, and inhibiting cell apoptosis. This suggests that royal jelly could be used as an adjuvant therapy in patients on long-term HDU medication.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Leila Rouhi, Sirisha M. Cheedipudi, Suet Nee Chen, Siyang Fan, Raffaella Lombardi, Xiaofan Chen, Cristian Coarfa, Matthew J. Robertson, Priyatansh Gurha, Ali J. Marian
Summary: The study identified that TMEM43 haploinsufficiency leads to activation of the DDR and TP53 pathways, resulting in increased expression of SASP and an age-dependent pro-fibrotic cardiomyopathy. The shared mechanism in the pathogenesis of cardiomyopathies caused by mutations involving nuclear envelope proteins may involve DNA damage response.
CARDIOVASCULAR RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Yuxuan Ma, Zhangwei Lu, Bin Jia, Ye Shi, Jun Dong, Shuoxing Jiang, Zhe Li
Summary: This study introduces a targeted treatment for rheumatoid arthritis (RA) using folic acid-modified triangular DNA origami nanostructures (FA-tDONs). The FA-tDONs can efficiently scavenge reactive oxygen species (ROS) and nitric oxide (NO), leading to the transition of pro-inflammatory macrophages to an anti-inflammatory phenotype. In an RA mouse model, FA-tDONs treatment effectively alleviates synovial inflammation and cartilage damage, attenuating disease progression.
Article
Medicine, Research & Experimental
Joao Victor Silva-Silva, Carla J. Moragas-Tellis, Maria S. S. Chagas, Paulo Victor R. Souza, Davyson L. Moreira, Celeste S. F. de Souza, Kerolain F. Teixeira, Arthur R. Cenci, Aldo S. de Oliveira, Fernando Almeida-Souza, Maria D. Behrens, Katia S. Calabrese
Summary: This study evaluated the leishmanicidal activity of a crude extract and anthocyanidin-rich fractions from Arrabidaea chica, as well as three isolated anthocyanidins. The results showed promising anti-leishmanial effects of these compounds, indicating their potential as therapeutic agents for leishmaniasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Spectroscopy
Bo Zheng, Binhui Pan, Sheng Xu, Zhihua Xu, Guangrong Lu, FangYan Wang, Biyun Fang, ChangLong Xu
Summary: Research has shown that circulating miRNAs can be used as novel diagnostic and prognostic markers for patients with inflammatory bowel diseases (IBD). In this study, a fluorescent probe was developed for simultaneous detection of two serum biomarkers (miR-23a and miR-223) associated with ulcerative colitis (UC) activity. The method showed high selectivity and has the potential for clinical application.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Shikai Liu, Wenting Li, Hengxing Chen, Jialing Zhou, Shuming Dong, Pengyu Zang, Boshi Tian, He Ding, Shili Gai, Piaoping Yang, Yanli Zhao
Summary: This study presents a two-dimensional nanoplatform that integrates a NO donor-modified LiYF4:Ce scintillator and graphitic carbon nitride nanosheets to generate highly cytotoxic peroxynitrite (ONOO-) on demand. The ONOO- effectively enhances the therapeutic efficacy of radiotherapy by inducing mitochondrial and DNA damage and inhibiting glutamine synthetase (GS) to delay DNA damage repair, overcoming the limitations of clinical radiotherapy.
Article
Multidisciplinary Sciences
Feng Li, Tsz Y. Lo, Leann Miles, Qin Wang, Harun N. Noristani, Dan Li, Jingwen Niu, Shannon Trombley, Jessica Goldshteyn, Chuxi Wang, Shuchao Wang, Jingyun Qiu, Katarzyna Pogoda, Kalpana Mandal, Megan Brewster, Panteleimon Rompolas, Ye He, Paul A. Janmey, Gareth M. Thomas, Shuxin Li, Yuanquan Song
Summary: The Atr-Chek1 pathway, involved in cell cycle and DNA damage response, inhibits axon regeneration in response to Piezo-mediated mechanosensation, affecting functional recovery. Targeting this pathway could potentially be useful for treating nervous system trauma.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Chen Huang, Lijun Chen, Sara R. Savage, Rodrigo Vargas Eguez, Yongchao Dou, Yize Li, Felipe da Veiga Leprevost, Eric J. Jaehnig, Jonathan T. Lei, Bo Wen, Michael Schnaubelt, Karsten Krug, Xiaoyu Song, Marcin Cieslik, Hui-Yin Chang, Matthew A. Wyczalkowski, Kai Li, Antonio Colaprico, Qing Kay Li, David J. Clark, Yingwei Hu, Liwei Cao, Jianbo Pan, Yuefan Wang, Kyung-Cho Cho, Zhiao Shi, Yuxing Liao, Wen Jiang, Meenakshi Anurag, Jiayi Ji, Seungyeul Yoo, Daniel Cui Zhou, Wen-Wei Liang, Michael Wendl, Pankaj Vats, Steven A. Carr, D. R. Mani, Zhen Zhang, Jiang Qian, Xi S. Chen, Alexander R. Pico, Pei Wang, Arul M. Chinnaiyan, Karen A. Ketchum, Christopher R. Kinsinger, Ana Robles, Eunkyung An, Tara Hiltke, Mehdi Mesri, Mathangi Thiagarajan, Alissa M. Weaver, Andrew G. Sikora, Jan Lubinski, Malgorzata Wierzbicka, Maciej Wiznerowicz, Shankha Satpathy, Michael A. Gillette, George Miles, Matthew J. Ellis, Gilbert S. Omenn, Henry Rodriguez, Emily S. Boja, Saravana M. Dhanasekaran, Li Ding, Alexey Nesvizhskii, Adel K. El-Naggar, Daniel W. Chan, Hui Zhang, Bing Zhang
Summary: This study presents a proteogenomic analysis of HPV-negative HNSCCs, identifying potential therapeutic targets and uncovering tumor characteristics such as immune status and resistance mechanisms. The findings suggest new strategies for stratifying HNSCC and improving treatment outcomes.
Article
Oncology
Liang-Bo Wang, Alla Karpova, Marina A. Gritsenko, Jennifer E. Kyle, Song Cao, Yize Li, Dmitry Rykunov, Antonio Colaprico, Joseph H. Rothstein, Runyu Hong, Vasileios Stathias, MacIntosh Cornwell, Francesca Petralia, Yige Wu, Boris Reva, Karsten Krug, Pietro Pugliese, Emily Kawaler, Lindsey K. Olsen, Wen-Wei Liang, Xiaoyu Song, Yongchao Dou, Michael C. Wendl, Wagma Caravan, Wenke Liu, Daniel Cui Zhou, Jiayi Ji, Chia-Feng Tsai, Vladislav A. Petyuk, Jamie Moon, Weiping Ma, Rosalie K. Chu, Karl K. Weitz, Ronald J. Moore, Matthew E. Monroe, Rui Zhao, Xiaolu Yang, Seungyeul Yoo, Azra Krek, Alexis Demopoulos, Houxiang Zhu, Matthew A. Wyczalkowski, Joshua F. McMichael, Brittany L. Henderson, Caleb M. Lindgren, Hannah Boekweg, Shuangjia Lu, Jessika Baral, Lijun Yao, Kelly G. Stratton, Lisa M. Bramer, Erika Zink, Sneha P. Couvillion, Kent J. Bloodsworth, Shankha Satpathy, Weiva Sieh, Simina M. Boca, Stephan Schurer, Feng Chen, Maciej Wiznerowicz, Karen A. Ketchum, Emily S. Boja, Christopher R. Kinsinger, Ana Robles, Tara Hiltke, Mathangi Thiagarajan, Alexey Nesvizhskii, Bing Zhang, D. R. Mani, Michele Ceccarelli, Xi S. Chen, Sandra L. Cottingham, Qing Kay Li, Albert H. Kim, David Fenyo, Kelly Ruggles, Henry Rodriguez, Mehdi Mesri, Samuel H. Payne, Adam C. Resnick, Pei Wang, Richard D. Smith, Antonio Iavarone, Milan G. Chheda, Jill S. Barnholtz-Sloan, Karin D. Rodland, Tao Liu, Li Ding
Summary: Understanding the molecular pathogenesis of glioblastoma is crucial for improving diagnosis and treatment. Integrated analysis of genomic, proteomic, and metabolomic data on treatment-naive glioblastomas has identified key phosphorylation events and potential targets for specific tumor alterations. Immune subtypes with distinct immune cell types were discovered, and specific histone acetylation patterns were correlated with these subtypes, providing insights for stratification of patients for more effective treatment.
Article
Oncology
Akihiko Miyanaga, Masaru Matsumoto, Jessica A. Beck, Izumi Horikawa, Takahiro Oike, Hirokazu Okayama, Hiromi Tanaka, Sandra S. Burkett, Ana I. Robles, Mohammed Khan, Delphine Lissa, Masahiro Seike, Akihiko Gemma, Hiroyuki Mano, Curtis C. Harris
Summary: Chromosomal inversions involving ALK and EML4 generate fusion protein EML4-ALK in NSCLC. Functional study on normal human cells revealed that EML4-ALK induces cellular senescence and accelerated proliferation, with different signaling pathways contributing to the phenotypic outcomes. The expression of hTERT is critical for EML4-ALK to manifest its in vitro transforming activity in human cells.
Editorial Material
Multidisciplinary Sciences
Eva Doka, Elias S. J. Arner, Edward E. Schmidt, Tobias P. Dick, Albert van der Vliet, Jing Yang, Reka Szatmari, Tamas Ditroi, John L. Wallace, Giuseppe Cirino, Kenneth Olson, Hozumi Motohashi, Jon M. Fukuto, Michael D. Pluth, Martin Feelisch, Takaaki Akaike, David A. Wink, Louis J. Ignarro, Peter Nagy
Summary: The recent report by Fan et al. alleging the inadequacy of the ProPerDP method for protein persulfidation detection is not supported by their data and is based on methodological shortcomings. Their assumptions and conclusions have not been confirmed by other methods.
Article
Biology
Anne C. Gilmore, Sarah J. Flaherty, Veena Somasundaram, David A. Scheiblin, Stephen J. Lockett, David A. Wink, William F. Heinz
Summary: The study presents a 2D live-cell chamber that approximates the tumor microenvironment, demonstrating how breast cancer cells and macrophages generate gradients and self-organize. This in vitro tumorigenesis model simplifies the study of cancer cell behavior in different microenvironment conditions.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Hanna T. Sjoberg, Yiannis Philippou, Anette L. Magnussen, Iain D. C. Tullis, Esther Bridges, Andrea Chatrian, Joel Lefebvre, Ka Ho Tam, Emma A. Murphy, Jens Rittscher, Dina Preise, Lilach Agemy, Tamar Yechezkel, Sean C. Smart, Paul Kinchesh, Stuart Gilchrist, Danny P. Allen, David A. Scheiblin, Stephen J. Lockett, David A. Wink, Alastair D. Lamb, Ian G. Mills, Adrian Harris, Ruth J. Muschel, Boris Vojnovic, Avigdor Scherz, Freddie C. Hamdy, Richard J. Bryant
Summary: The study investigated the combination of fractionated radiotherapy (FRT) and vascular-targeted photodynamic therapy (VTP) in treating prostate cancer (PCa). Results showed that FRT induced vascular normalization changes in PCa tumors, and the sequential delivery of FRT followed by VTP significantly delayed tumor growth and improved overall survival in pre-clinical models. The findings suggest that combining FRT and VTP may be a promising multimodal approach in PCa therapy, which could inform early phase clinical trials.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Liwei Cao, Chen Huang, Daniel Cui Zhou, Yingwei Hu, T. Mamie Lih, Sara R. Savage, Karsten Krug, David J. Clark, Michael Schnaubelt, Lijun Chen, Felipe da Veiga Leprevost, Rodrigo Vargas Eguez, Weiming Yang, Jianbo Pan, Bo Wen, Yongchao Dou, Wen Jiang, Yuxing Liao, Zhiao Shi, Nadezhda Terekhanova, Song Cao, Rita Jui-Hsien Lu, Yize Li, Ruiyang Liu, Houxiang Zhu, Peter Ronning, Yige Wu, Matthew A. Wyczalkowski, Hariharan Easwaran, Ludmila Danilova, Arvind Singh Mer, Seungyeul Yoo, Joshua M. Wang, Wenke Liu, Benjamin Haibe-Kains, Mathangi Thiagarajan, Scott D. Jewell, Galen Hostetter, Chelsea J. Newton, Qing Kay Li, Michael H. Roehr, David Fenyo, Pei Wang, Alexey Nesvizhskii, D. R. Mani, Gilbert S. Omenn, Emily S. Boja, Mehdi Mesri, Ana Robles, Henry Rodriguez, Oliver F. Bathe, Daniel W. Chan, Ralph H. Hruban, Li Ding, Bing Zhang, Hui Zhang
Summary: This study conducted comprehensive proteogenomic analysis of PDAC to understand the molecular alterations that drive oncogenesis. Multiple analyses were performed on tissues from patients, providing valuable resources for early detection and identification of therapeutic targets.
Review
Biochemistry & Molecular Biology
Christopher L. McGinity, Erika M. Palmieri, Veena Somasundaram, Dibyangana D. Bhattacharyya, Lisa A. Ridnour, Robert Y. S. Cheng, Aideen E. Ryan, Sharon A. Glynn, Douglas D. Thomas, Katrina M. Miranda, Stephen K. Anderson, Stephen J. Lockett, Daniel W. McVicar, David A. Wink
Summary: The metabolic requirements and functions of cancer and normal tissues differ significantly, with distorted vasculature and hypoxia-induced stress commonly observed in tumor microenvironments. Recent studies have shown that alterations in various metabolic pathways dictate tumor behavior and response to therapy, with metabolic heterogeneity within the tumor microenvironment playing a key role in promoting tumor behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Inorganic & Nuclear
Katrina M. Miranda, Lisa A. Ridnour, Christopher L. McGinity, Dana Bhattacharyya, David A. Wink
Summary: The mechanistic roles of nitric oxide (NO) in cancer progression are complex, with both pro-and antitumorigenic effects. Understanding the concentration, spatial, and temporal dependence of responses to NO is crucial for developing effective cancer treatments.
INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Daniele Mancardi, Pasquale Pagliaro, Lisa A. Ridnour, Carlo G. Tocchetti, Katrina Miranda, Magdalena Juhaszova, Steven J. Sollott, David A. Wink, Nazareno Paolocci
Summary: Nitroxyl (HNO), the one electron-reduction product of nitric oxide (NO), can limit ischemia-reperfusion (I/R) injury by inhibiting the opening of mitochondrial permeability transition pore (mPTP). This study provides insights into the mechanisms of HNO-mediated cardioprotection.
Review
Oncology
Tejaswini P. Reddy, Sharon A. Glynn, Timothy R. Billiar, David A. Wink, Jenny C. Chang
Summary: Targeted therapies that reduce cancer metastasis, target chemoresistant cancer stem cells, and enhance the efficacy of systemic chemo/radiotherapies are crucial in reducing cancer-related mortality. Targeting nitric oxide synthase (NOS), a protein in the tumor microenvironment, has shown promise as a therapeutic strategy in various solid malignancies. This review examines the role of nitric oxide (NO) in tumor progression and metastasis, as well as preclinical studies evaluating NOS inhibitors as anticancer therapies. The prospects and challenges of using NOS inhibitors in a clinical setting are also discussed.
CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Veena Somasundaram, Lisa A. Ridnour, Robert Ys Cheng, Abigail J. Walke, Noemi Kedei, Dibyangana D. Bhattacharyya, Adelaide L. Wink, Elijah F. Edmondson, Donna Butcher, Andrew C. Warner, Tiffany H. Dorsey, David A. Scheiblin, William Heinz, Richard J. Bryant, Robert J. Kinders, Stanley Lipkowitz, Stephen T. C. Wong, Milind Pore, Stephen M. Hewitt, Daniel W. McVicar, Stephen K. Anderson, Jenny Chang, Sharon A. Glynn, Stefan Ambs, Stephen J. Lockett, David A. Wink
Summary: The levels of NOS2/COX2 in tumors influence the polarization and spatial location of lymphoid cells, including CD8(+) T cells. High levels of NOS2/COX2 are associated with the exclusion of CD8(+) T cells from the tumor epithelium. The drug inhibitor indomethacin can improve the penetration ability of CD8(+) T cells and reduce tumor growth, leading to tumor regression.
Article
Biochemistry & Molecular Biology
Dhisa Minerva, Nuha Loling Othman, Takashi Nakazawa, Yukinobu Ito, Makoto Yoshida, Akiteru Goto, Takashi Suzuki
Summary: Chemotaxis plays an important role in angiogenesis, but in arterial patch grafting-induced angiogenesis, the VEGFA concentration gradient is decreasing. The formation of new blood vessels shows twisted and congested morphology, distinguishable from non-pathological vessels. Through a mathematical model and numerical simulations, we found that the growth speed of new vessels oscillates and observed crowded and congested blood vessel formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)