B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells

Age-Associated B Cells

(2020) Michael P. Cancro   Annual Review of Immunology

SPEN integrates transcriptional and epigenetic control of X-inactivation

(2020) François Dossin et al.   NATURE

Widespread organ tolerance to Xist loss and X reactivation except under chronic stress in the gut

(2020) Lin Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity

(2020) Yiwen Lu et al.   CELL

The many faces of Polycomb regulation by RNA

(2020) Mafalda Almeida et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9

(2020) Leonhard X. Heinz et al.   NATURE

High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade

(2020) Kobe C. Yuen et al.   NATURE MEDICINE

Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

(2020) Ava C Carter et al.   eLife

Factors associated with COVID-19-related death using OpenSAFELY

(2020) Elizabeth J. Williamson et al.   NATURE

Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

(2020) Jeong Seok Lee et al.   Science Immunology

A protein assembly mediates Xist localization and gene silencing

(2020) Amy Pandya-Jones et al.   NATURE

Sex differences in immune responses that underlie COVID-19 disease outcomes

(2020) Takehiro Takahashi et al.   NATURE

Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19

(2020) Matthew C. Woodruff et al.   NATURE IMMUNOLOGY

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

(2020) Prabhu S. Arunachalam et al.   SCIENCE

The impact of sex on gene expression across human tissues

(2020) Meritxell Oliva et al.   SCIENCE

Cell-Type-Specific Immune Dysregulation in Severely Ill COVID-19 Patients

(2020) Changfu Yao et al.   Cell Reports

TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

(2019) Xiancai Ma et al.   eLife

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

IFNγ induces epigenetic programming of human T-bethi B cells and promotesTLR7/8 and IL-21 induced differentiation

(2019) Esther Zumaquero et al.   eLife

The immune cell landscape in kidneys of patients with lupus nephritis

(2019) Arnon Arazi et al.   NATURE IMMUNOLOGY

Xist RNA in action: Past, present, and future

(2019) Agnese Loda et al.   PLoS Genetics

Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus

(2019) Pragnesh Mistry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A GPR174–CCL21 module imparts sexual dimorphism to humoral immunity

(2019) Ruozhu Zhao et al.   NATURE

Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion

(2018) Robin L. Adrianse et al.   Epigenetics & Chromatin

Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks

(2018) Adam J. Rubin et al.   CELL

The Implication of Early Chromatin Changes in X Chromosome Inactivation

(2018) Jan Jakub Żylicz et al.   CELL

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

ERVmap analysis reveals genome-wide transcription of human endogenous retroviruses

(2018) Maria Tokuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Landscape of X chromosome inactivation across human tissues

(2017) Taru Tukiainen et al.   NATURE

Mechanistic insights in X-chromosome inactivation

(2017) Zhipeng Lu et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

When the Lyon(ized chromosome) roars: ongoing expression from an inactive X chromosome

(2017) Laura Carrel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Repeat E anchors Xist RNA to the inactive X chromosomal compartment through CDKN1A-interacting protein (CIZ1)

(2017) Hongjae Sunwoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

(2017) Peter J Skene et al.   eLife

RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure

(2016) Zhipeng Lu et al.   CELL

Female mice lacking Xist RNA show partial dosage compensation and survive to term

(2016) Lin Yang et al.   GENES & DEVELOPMENT

Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X

(2016) Jianle Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Discovery of Xist RNA Binding Proteins

(2015) Ci Chu et al.   CELL

Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

(2015) Kira Rubtsova et al.   JOURNAL OF IMMUNOLOGY

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

(2015) Colleen A. McHugh et al.   NATURE

A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation

(2015) A. Minajigi et al.   SCIENCE

A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing

(2015) Benoit Moindrot et al.   Cell Reports

Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells

(2015) Asun Monfort et al.   Cell Reports

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Widespread contribution of transposable elements to the innovation of gene regulatory networks

(2014) Vasavi Sundaram et al.   GENOME RESEARCH

Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers

(2014) Leighton J Core et al.   NATURE GENETICS

Genetic and pharmacological reactivation of the mammalian inactive X chromosome

(2014) S. Bhatnagar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice

(2013) Eda Yildirim et al.   CELL

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

TLR7 and TLR9 in SLE: when sensing self goes wrong

(2012) T. Celhar et al.   IMMUNOLOGIC RESEARCH

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

(2011) Y. Hao et al.   BLOOD

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

(2011) A. V. Rubtsov et al.   BLOOD

KAP1 Protein: An Enigmatic Master Regulator of the Genome

(2011) Sushma Iyengar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

The Matrix Protein hnRNP U Is Required for Chromosomal Localization of Xist RNA

(2010) Yuko Hasegawa et al.   DEVELOPMENTAL CELL

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse

(2008) Y. Hoki et al.   DEVELOPMENT

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY